scholarly journals Aryl hydrocarbon receptor acts as a tumor suppressor in a syngeneic MC38 colon carcinoma tumor model

Hypoxia ◽  
2019 ◽  
Vol Volume 7 ◽  
pp. 1-16
Author(s):  
Poonam Yakkundi ◽  
Eleanor Gonsalves ◽  
Maria Galou-Lameyer ◽  
Mark Selby ◽  
William Chan
Keyword(s):  
Tumor Suppressor ◽  
Aryl Hydrocarbon Receptor ◽  
Colon Carcinoma ◽  
Tumor Model ◽  
Aryl Hydrocarbon ◽  
Carcinoma Tumor

Author response for "Anti‐EpCAM RNA aptamer‐conjugated liposomal doxorubicin as an efficient targeted therapy in mice bearing colon carcinoma tumor model"

2020 ◽  
Author(s):  
Mohammad Mashreghi ◽  
Parvin Zamani ◽  
Maryam Karimi ◽  
Amin Mehrabian ◽  
Mahdieh Arabsalmani ◽  
...  
Keyword(s):  
Targeted Therapy ◽  
Colon Carcinoma ◽  
Liposomal Doxorubicin ◽  
Tumor Model ◽  
Author Response ◽  
Carcinoma Tumor

scholarly journals The aryl hydrocarbon receptor is a tumor suppressor–like gene in glioblastoma

2019 ◽  
Vol 294 (29) ◽  
pp. 11342-11353 ◽  
Author(s):  
Un-Ho Jin ◽  
Keshav Karki ◽  
Yating Cheng ◽  
Sharon K. Michelhaugh ◽  
Sandeep Mittal ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Aryl Hydrocarbon Receptor ◽  
Aryl Hydrocarbon

MicroRNA miR-107 is overexpressed in pituitary adenomas and inhibits the expression of aryl hydrocarbon receptor-interacting protein in vitro

2012 ◽  
Vol 303 (6) ◽  
pp. E708-E719 ◽  
Author(s):  
Giampaolo Trivellin ◽  
Henriett Butz ◽  
Juliette Delhove ◽  
Susana Igreja ◽  
Harvinder S. Chahal ◽  
...  
Keyword(s):  
Pituitary Adenoma ◽  
Tumor Suppressor ◽  
Aryl Hydrocarbon Receptor ◽  
Pituitary Adenomas ◽  
Expression Profiles ◽  
Luciferase Assay ◽  
Human Neuroblastoma ◽  
Interacting Protein ◽  
Aryl Hydrocarbon

Abnormal microRNA (miRNA) expression profiles have recently been associated with sporadic pituitary adenomas, suggesting that miRNAs can contribute to tumor formation; miRNAs are small noncoding RNAs that inhibit posttranscriptional expression of target mRNAs by binding to target sequences usually located in the 3′-UTR. In this study, we investigated the role played by miR-107, a miRNA associated with different human cancers, in sporadic pituitary adenomas and its interaction with the pituitary tumor suppressor gene aryl hydrocarbon receptor-interacting protein ( AIP). miR-107 expression was evaluated in pituitary adenoma and normal pituitary samples using microRNA screen TLDA (TaqMan Low-Density Array) and RT-qPCR assays. We show that miR-107 expression was significantly upregulated in GH-secreting and nonfunctioning pituitary adenomas. We found that human AIP-3′-UTR is a target of miR-107 since miR-107 inhibited in vitro AIP expression to 53.9 ± 2% of the miRNA control in a luciferase assay and reduced endogenous AIP mRNA expression to 53 ± 22% of the miRNA control in human cells. However, we did not observe a negative correlation between AIP and miR-107 expression in the human tumor samples. Furthermore, we show that miR-107 overexpression inhibited cell proliferation in human neuroblastoma and rat pituitary adenoma cells. In conclusion, miR-107 is overexpressed in pituitary adenomas and may act as a tumor suppressor. We have identified and confirmed AIP as a miR-107 target gene. Expression data in human samples suggest that the expression of AIP and miR-107 could be influenced by a combination of tumorigenic factors as well as compensatory mechanisms stimulated by the tumorigenic process.

scholarly journals The Aryl Hydrocarbon Receptor Functions as a Tumor Suppressor of Liver Carcinogenesis

2009 ◽  
Vol 70 (1) ◽  
pp. 212-220 ◽  
Author(s):  
Yunxia Fan ◽  
Gregory P. Boivin ◽  
Erik S. Knudsen ◽  
Daniel W. Nebert ◽  
Ying Xia ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Aryl Hydrocarbon Receptor ◽  
Liver Carcinogenesis ◽  
Aryl Hydrocarbon
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