End-tidal CO2 levels lower in subclinical and overt hypothyroidism than healthy controls; no relationship to thyroid function tests

Objective: Investigating high iodine containing low osmolar contrast agent (visipaque) effects on thyroid function tests and thyroid sonography characteristics. Methods: 65 euthyroid cases and 92 controls composed the samples in baseline. Thyroid function tests, Urine Iodine Concentration (UIC) and thyroid sonography were conducted for both groups before and 1 and 3 months after angiography. Serum levels of T4, T3, T3RU, TSH, TPO-Ab and UIC were measured, and hypo/heyperthyroidism prevalence was compared between groups. Results: Mean T3,T4 and TSH changes 1 month after angiography were insignificant in both groups (P:0.61,P:0.4 and P:0.14, P:0.23 in cases and controls for T3 and T4). Medians among cases and controls were 12.8 and 16.75 µg/dl, respectively, at baseline. These values varied to 28.45 and 15.2µg/dl, and 12.95 and 14.2µg/dl 1 month and 3 months after angiography in case and control groups, respectively. UIC increase one month after angiography was significant among cases (P=0.002). TPO-Ab+ were same 3 months after angiography. Thyroid volume changes were significant among cases (P<0.001) and insignificant among controls (P=0.680). No significant difference was seen between cases and controls in overt hypothyroidism, however, a considerable change was seen in thyroid volume and UIC one month after angiography among cases. The hypothyroidism rate among cases was insignificant which may be either related to few cases or short half-life of visipaque (2.1 hour) so that 97% of injected dose was excreted in urine within 24 hours. Conclusion: Thyroid function test is not recommended before angiography in patients without previous thyroid records.

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COGNITIVE FUNCTION IN WORKING POPULATION WITH ABNORMAL THYROID FUNCTION TEST

10.36106/gjra/3000829 ◽

2020 ◽

pp. 1-3

Author(s):

Nilanjana Debnath ◽

Keshao B. Nagpure ◽

Preetam N. Wasnik

Keyword(s):

Cognitive Function ◽

Thyroid Function ◽

Thyroid Dysfunction ◽

Mmse Score ◽

Overt Hypothyroidism ◽

Thyroid Function Tests ◽

Working Population ◽

Function Tests ◽

The Mean ◽

Overt Hyperthyroidism

Context: Cognitive impairment is linked to thyroid dysfunction in various studies; however, the evidence is mixed. Aims: To determine cognitive function in the working population with abnormal thyroid function tests. Settings: Outpatient department of Medicine in a tertiary care hospital located in Central India. Design: Hospital-based, cross-sectional study. Methods and Material:100 patients between 15-64 years of age with different patterns of thyroid dysfunction were subjected to cognitive function testing via the Mini-Mental Status Examination (MMSE) questionnaire. Statistical analysis used: The data obtained was coded in a Microsoft Excel Worksheet and analyzed by SPSS software version 21. Results: 100 patients (11 % men and 89 % women) were included in the present study. The mean age of the study population was 37.11±8.76 years. 87 % had overt hypothyroidism, 6 % had subclinical hypothyroidism, 6 % had overt hyperthyroidism. The mean MMSE score of patients with abnormal thyroid function tests was 27.62 ±2.04 (Range 23-30). The mean MMSE score in patients with overt hypothyroidism was 27.54 ± 2.07, that of overt hyperthyroidism 28.33 ±1.03, and that of subclinical hypothyroidism was 27.67 ± 2.50. MMSE scores among different patterns of thyroid dysfunction were not found to be statistically significant. The MMSE scores between newly and previously diagnosed patients with thyroid dysfunction were not statistically significant. (28.3 ± 1.06 vs 27.54 ± 2.12). Conclusions: The results suggest no association between cognitive function and abnormal thyroid function tests in the working population.

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Effects of high iodine containing low osmolar contrast agent (visipaque) on thyroid function tests

10.1101/513291 ◽

2019 ◽

Keyword(s):

Contrast Agent ◽

Thyroid Function ◽

Thyroid Volume ◽

Thyroid Function Test ◽

Iodine Concentration ◽

Overt Hypothyroidism ◽

Thyroid Function Tests ◽

High Iodine ◽

Function Tests ◽

Significant Difference

AbstractObjectiveInvestigating high iodine containing low osmolar contrast agent (visipaque) effects on thyroid function tests and thyroid sonography characteristics.Methods65 euthyroid cases and 92 controls composed the samples in the baseline. Thyroid function tests, Urine Iodine Concentration (UIC) and thyroid sonography were conducted for both groups before and 1 and 3 months after angiography. Serum levels of T4, T3, T3RU, TSH, TPO-Ab, and UIC were measured, and hypo/hyperthyroidism prevalence was compared between groups.ResultsMean T3, T4 and TSH change 1 month after angiography were insignificant in both groups (P:0.61, P:0.4 and P:0.14, P:0.23 in cases and controls for T3 and T4). Medians among cases and controls were 12.8 and 16.75 μg/dl, respectively, at baseline. These values varied to 28.45 and 15.2μg/dl, and 12.95 and 14.2μg/dl 1 month and 3 months after angiography in case and control groups, respectively. UIC increase one month after angiography was significant among cases (P=0.002). TPO-Ab+ were same 3 months after angiography. Thyroid volume changes were significant among cases (P<0.001) and insignificant among controls (P=0.680). No significant difference was seen between cases and controls in overt hypothyroidism, however, a considerable change was seen in thyroid volume and UIC one month after angiography among cases. The hypothyroidism rate among cases was insignificant which may be either related to few cases or short half-life of visipaque (2.1 hours) so that 97% of the injected dose was excreted in urine within 24 hours.ConclusionThyroid function test is not recommended before angiography in patients without previous thyroid records.

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