scholarly journals Prostate-Specific Membrane Antigen and Esterase Dual Responsive Camptothecin–Oligopeptide Self-Assembled Nanoparticles for Efficient Anticancer Drug Delivery

2021 ◽  
Vol Volume 16 ◽  
pp. 7959-7974
Author(s):  
Bing Xu ◽  
Mengmeng Yan ◽  
Fei Zhou ◽  
Desheng Cai ◽  
Wenbo Guo ◽  
...  

RSC Advances ◽  
2016 ◽  
Vol 6 (42) ◽  
pp. 35658-35667 ◽  
Author(s):  
Lingling Zhao ◽  
Yajuan Zhang ◽  
Jia Shao ◽  
Hongze Liang ◽  
Haining Na ◽  
...  

Folate-conjugated dual-responsive micelles were developed, sustained and sensitive drug release from the drug loaded micelles was observed. Folate-targeted micelles showed higher anticancer activity and enhanced cellar uptake than non-targeted ones.



Nano Research ◽  
2017 ◽  
Vol 11 (2) ◽  
pp. 1168-1168 ◽  
Author(s):  
Ka Young Kim ◽  
Hanyong Jin ◽  
Jaehyeon Park ◽  
Sung Ho Jung ◽  
Ji Ha Lee ◽  
...  


RSC Advances ◽  
2014 ◽  
Vol 4 (98) ◽  
pp. 55139-55149 ◽  
Author(s):  
Jinlong Yang ◽  
Chunmei Gao ◽  
Shaoyu Lü ◽  
Xinggang Wang ◽  
Mingjia Chen ◽  
...  


2019 ◽  
Vol 220 (5) ◽  
pp. 1800528 ◽  
Author(s):  
Du Beibei ◽  
Fan Tiantang ◽  
Li Jiafeng ◽  
Gong Li ◽  
Zhang Qin ◽  
...  


Author(s):  
Jaleh Varshosaz ◽  
Somayeh Taymouri ◽  
Erfaneh Ghassami


2020 ◽  
Vol 20 (11) ◽  
pp. 6959-6967
Author(s):  
Rimesh Augustine ◽  
Dae-Kyoung Kim ◽  
Ho An Kim ◽  
Jae Ho Kim ◽  
Il Kim

A series of ABC triblock poly(N-isopropylacrylamide)75-block-poly(L-lysine)35-block-poly(L-histidine)n (p(NIPAM)75-b-p(Lys)35-b-p(His)N) (N = 35,50,75,100) copolymer bio-conjugates were prepared by combining reversible addition-fragmentation chain transfer polymerization and fast ring-opening polymerization of N-carboxyanhydride a-amino acid using 1,3-dicyclohexylimidazolium hydrogen carbonate as a catalyst. All the resulting triblock copolymers self-assembled into spherical micellar aggregates in aqueous solution, irrespective of the chain length of the histidine block. The micellar aggregates encapsulated the anticancer drug doxorubicin (Dox) and exhibited high drug loading efficiency. Temperature and pH stimuli were applied to investigate the controlled release of Dox. The non-cytotoxic nature of the polymers was investigated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Cellular uptake of the Dox-loaded micelles revealed that the micelles successfully release Dox in cancer cells in response to pH- and temperature-induced morphological change. In-vitro studies further confirmed that the Dox-loaded triblock copolymer micelle is an excellent platform for drug delivery.



Drug Delivery ◽  
2013 ◽  
Vol 21 (4) ◽  
pp. 258-264 ◽  
Author(s):  
Daquan Chen ◽  
Hongyun Yu ◽  
Kaoxiang Sun ◽  
Wanhui Liu ◽  
Hongbo Wang




AIChE Journal ◽  
2009 ◽  
Vol 56 (7) ◽  
pp. 1922-1931 ◽  
Author(s):  
Xin Dong Guo ◽  
Li Juan Zhang ◽  
Yun Chen ◽  
Yu Qian


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