Antiviral Activity of Zinc Oxide Nanoparticles Mediated by Plumbago indica L. Extract Against Herpes Simplex Virus Type 1 (HSV-1)

A series of new cyclohexenyl nucleosides is synthesized by coupling the heterocyclic bases with a protected cyclohexenyl precursor under Mitsunobu conditions. The compounds were evaluated for their antiviral and cytostatic activity. Pronounced activity against herpes simplex virus type 1 and type 2 was observed for the 2,6-diaminopurine analogue.

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Comparative Analysis of the Antiviral Activity of Camel, Bovine, and Human Lactoperoxidases Against Herpes Simplex Virus Type 1

Applied Biochemistry and Biotechnology ◽

10.1007/s12010-016-2327-x ◽

2016 ◽

Vol 182 (1) ◽

pp. 294-310 ◽

Cited By ~ 20

Author(s):

Esmail M. El-Fakharany ◽

Vladimir N. Uversky ◽

Elrashdy M. Redwan

Keyword(s):

Herpes Simplex Virus ◽

Comparative Analysis ◽

Herpes Simplex ◽

Antiviral Activity ◽

Virus Type ◽

Herpes Simplex Virus Type ◽

Simplex Virus

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Synthesis of (E)-5-(3,3,3-trifluoro-1-propenyl)-2'-deoxyuridine and related analogs: potent and unusually selective antiviral activity of (E)-5-(3,3,3-trifluoro-1-propenyl)-2'-deoxyridine against herpes simplex virus type 1

Journal of Medicinal Chemistry ◽

10.1021/jm00369a009 ◽

1984 ◽

Vol 27 (3) ◽

pp. 279-284 ◽

Cited By ~ 24

Author(s):

Donald E. Bergstrom ◽

Jerry L. Ruth ◽

P. Anantha Reddy ◽

Erik De Clercq

Keyword(s):

Herpes Simplex Virus ◽

Herpes Simplex ◽

Antiviral Activity ◽

Virus Type ◽

Herpes Simplex Virus Type ◽

Simplex Virus

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Scopadulciol is an Inhibitor of Herpes Simplex Virus Type 1 and a Potentiator of Aciclovir

Antiviral Chemistry and Chemotherapy ◽

10.1177/095632029600700204 ◽

1996 ◽

Vol 7 (2) ◽

pp. 79-85 ◽

Cited By ~ 11

Author(s):

Kyoko Hayashi ◽

Toshimitsu Hayashi

Keyword(s):

Herpes Simplex Virus ◽

Herpes Simplex ◽

Antiviral Activity ◽

Virus Type ◽

Hela Cells ◽

Herpes Simplex Virus Type ◽

Infected Cells ◽

Simplex Virus ◽

Hsv 1

The antiviral activity of scopadulciol (SDC), a tetracyclic diterpenoid with a chemical structure related to that of aphidicolin, isolated from Scoparia dulcis, was studied in vitro against herpes simplex virus type 1 (HSV-1). SDC was found to inhibit the virus replication as shown by reduction of virus production. The action was not due to the inhibition of viral DNA polymerase activity and virus penetration, but might involve, at least in part, a virucidal effect. SDC did not suppress the viral protein synthesis of infected cells when added at an early stage of HSV-1 replication, but did when added later. When aciclovir (ACV) and SDC were evaluated in combination for antiviral activity against HSV-1 replication and cytotoxicity, these drugs inhibited viral replication in HeLa cells synergistically, but the same combination did not produce synergistic cytotoxicity in HeLa cells. Studies of the deoxynucleotide pool sizes revealed that SDC increased the intracellular dNTP pools and ACV triphosphate level significantly in infected cells when the cells were treated with the combination. These results could account for the synergistic action between SDC and ACV.

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