scholarly journals Zerumbone-loaded nanostructured lipid carrier induces G2/M cell cycle arrest and apoptosis via mitochondrial pathway in a human lymphoblastic leukemia cell line

2014 ◽  
pp. 527 ◽  
Author(s):  
Abdullah Rasedee ◽  
Ahmad Bustaman Abdul ◽  
Nazariah Allaudin Zeenathul ◽  
Heshu Rahman ◽  
Swee Yeap ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Line ◽  
Lymphoblastic Leukemia ◽  
Leukemia Cell ◽  
Mitochondrial Pathway ◽  
Leukemia Cell Line ◽  
Nanostructured Lipid Carrier ◽  
M Cell ◽  
Cycle Arrest ◽  
Lymphoblastic Leukemia Cell Line

scholarly journals Apoptosis Inducing Activity of Diospyros melanoxylon Bark Extract on Molt-3 Cell Line via Activation of Mitochondrial Membrane Caspase Cascade and Cell Cycle Arrest with its Antioxidant Potential

2021 ◽  
Vol 71 (1) ◽  
Author(s):  
Nilanjana Deb ◽  
Tarun Jha ◽  
Snehasikta Swarnakar ◽  
Shila Elizabeth Besra
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Cell Line ◽  
Lymphoblastic Leukemia ◽  
Flow Cytometric Analysis ◽  
Leukemia Cell ◽  
Leukemia Cell Line ◽  
Bark Extract ◽  
Fluorescence Confocal Microscopy ◽  
Cycle Arrest

The present work aimed to investigate the apoptosis activity of Diospyros melanoxylon of bark extract (DMBE) on Molt-3 human acute T lymphoblastic leukemia cell line & RAW 264.7 murine macrophage cell lysate respectively. Cell growth inhibition was observed by using MTT assay. DMBE significantly decreased cell count and caused apoptosis, as confirmed by light, fluorescence, confocal microscopy and by flow-cytometric analysis using Annexin-V FITC and propidium iodide (PI). MOLT-3 cells showed DMBE induced cell cycle arrest, and apoptosis was mediated through mitochondrial intrinsic pathway involving the release of cytochrome c into the cytosol and activation of caspase-9 and caspase-3. DMBE induced changes in cellular ROS production upon stimulation with DCFDA.

Activation ofHOX11L2 by juxtaposition with 3?-BCL11B in an acute lymphoblastic leukemia cell line (HPB-ALL) with t(5;14)(q35;q32.2)

2003 ◽  
Vol 37 (1) ◽  
pp. 84-91 ◽  
Author(s):  
Roderick A.F. MacLeod ◽  
Stefan Nagel ◽  
Maren Kaufmann ◽  
Johannes W.G. Janssen ◽  
Hans G. Drexler
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Cell Line ◽  
Lymphoblastic Leukemia ◽  
Leukemia Cell ◽  
Leukemia Cell Line ◽  
Lymphoblastic Leukemia Cell Line

scholarly journals The oxidation of (−)-epigallocatechin-3-gallate inhibits T-cell acute lymphoblastic leukemia cell line HPB-ALL via the regulation of Notch1 expression

RSC Advances ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. 1679-1684 ◽  
Author(s):  
Yu-Na Wang ◽  
Jing Wang ◽  
Hao-Nan Yang ◽  
Bang-Lei Zhang ◽  
Pan Zhang ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
T Cell ◽  
Cell Line ◽  
Hematological Malignancy ◽  
Lymphoblastic Leukemia ◽  
Leukemia Cell ◽  
Leukemia Cell Line ◽  
Activating Mutations ◽  
Cell Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia Cell Line

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy, and commonly associated with activating mutations in the Notch1 pathway.

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