scholarly journals Combination of calcium sulfate and simvastatin-controlled release microspheres enhances bone repair in critical-sized rat calvarial bone defects

2015 ◽  
pp. 7231 ◽  
Author(s):  
Mei-Ling Ho ◽  
Yin-Chih Fu ◽  
Yan-Hsiung Wang ◽  
Chung-Hwan Chen ◽  
Chih-Kuang Wang ◽  
...  
Keyword(s):  
Controlled Release ◽  
Calcium Sulfate ◽  
Bone Repair ◽  
Bone Defects ◽  
Calvarial Bone

Regeneration of Bone Defects Using Bioactive Glass Combined with Adipose-derived Mesenchymal Stem Cells. An experimental in vivo study

2019 ◽  
Vol 70 (6) ◽  
pp. 1983-1987
Author(s):  
Cristian Trambitas ◽  
Anca Maria Pop ◽  
Alina Dia Trambitas Miron ◽  
Dorin Constantin Dorobantu ◽  
Flaviu Tabaran ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Bioactive Glass ◽  
Bone Repair ◽  
Bone Defects ◽  
Calvarial Bone ◽  
Specific Protocol ◽  
Repair Mechanisms ◽  
Male Wistar Rats

Large bone defects are a medical concern as these are often unable to heal spontaneously, based on the host bone repair mechanisms. In their treatment, bone tissue engineering techniques represent a promising approach by providing a guide for osseous regeneration. As bioactive glasses proved to have osteoconductive and osteoinductive properties, the aim of our study was to evaluate by histologic examination, the differences in the healing of critical-sized calvarial bone defects filled with bioactive glass combined with adipose-derived mesenchymal stem cells, compared to negative controls. We used 16 male Wistar rats subjected to a specific protocol based on which 2 calvarial bone defects were created in each animal, one was filled with Bon Alive S53P4 bioactive glass and adipose-derived stem cells and the other one was considered control. At intervals of one week during the following month, the animals were euthanized and the specimens from bone defects were histologically examined and compared. The results showed that this biomaterial was biocompatible and the first signs of osseous healing appeared in the third week. Bone Alive S53P4 bioactive glass could be an excellent bone substitute, reducing the need of bone grafts.

Bone Repair in Periodontal Defect Using a Composite of Allograft and Calcium Sulfate (DentoGen) and a Calcium Sulfate Barrier

2011 ◽  
Vol 37 (2) ◽  
pp. 287-292 ◽  
Author(s):  
Ziv Mazor ◽  
Sachin Mamidwar ◽  
John L. Ricci ◽  
Nick M. Tovar*
Keyword(s):  
Connective Tissue ◽  
Periodontal Disease ◽  
Bone Defect ◽  
Calcium Sulfate ◽  
Bone Repair ◽  
Bone Allograft ◽  
Bone Defects ◽  
Defect Analysis ◽  
Freeze Dried ◽  
Time Point

Abstract Deep bone defects are caused by the progression of periodontal disease, which breaks down bone and connective tissue that hold teeth in place. In this case, a 37-year-old male patient presented a deep bone defect with advanced periodontal disease around an upper canine. Medical-grade calcium sulfate was mixed with demineralized freeze-dried bone allograft and used to repair and regenerate the defect. Analysis of the radiographs at the 5-month time point showed the bone had completely regenerated.

Quantitative-radiographic and molecular-histological analysis of bone repair in critical and non-critical size rat calvarial bone defects

2008 ◽  
pp. 371-372
Author(s):  
Takahiro Honma ◽  
Tomoko Itagaki ◽  
Megumi Nakamura ◽  
Shinji Kamakura ◽  
Ichiro Takahashi ◽  
...  
Keyword(s):  
Bone Repair ◽  
Histological Analysis ◽  
Critical Size ◽  
Bone Defects ◽  
Calvarial Bone

Repair of rat calvarial bone defects by controlled release of rhBMP-2 from an injectable bone regeneration composite

2011 ◽  
Vol 6 (8) ◽  
pp. 614-621 ◽  
Author(s):  
Rongwei Tan ◽  
Zhending She ◽  
Mingbo Wang ◽  
Xing Yu ◽  
He Jin ◽  
...  
Keyword(s):  
Controlled Release ◽  
Bone Regeneration ◽  
Bone Defects ◽  
Calvarial Bone

Enhancement of repair in experimental calvarial bone defects using calcium sulfate and dextran beads

1993 ◽  
Vol 51 (5) ◽  
pp. 517-524 ◽  
Author(s):  
Robert V. Snyders ◽  
Barry L. Eppley ◽  
Marilyn Krukowski ◽  
John J. Delfino
Keyword(s):  
Calcium Sulfate ◽  
Bone Defects ◽  
Calvarial Bone

Multi-stage controllable degradation of strontium-doped calcium sulfate hemihydrate-Tricalcium phosphate microsphere composite as a substitute for osteoporotic bone defect repairing: Degradation behavior and bone response

2021 ◽  
Author(s):  
Qiuju Miao ◽  
Nan Jiang ◽  
Qinmeng Yang ◽  
Ismail mohamed Hussein ◽  
Zhen Luo ◽  
...  
Keyword(s):  
Tricalcium Phosphate ◽  
Calcium Sulfate ◽  
Bone Repair ◽  
Degradation Rate ◽  
Bone Defects ◽  
Osteoporotic Bone ◽  
Repair Materials ◽  
Bone Repair Materials ◽  
In Vivo Degradation

Abstract Various requirements for the repair of complex bone defects have motivated to development of scaffolds with adjustable degradation rates and biological functions. Tricalcium phosphate and calcium sulfate are the most commonly used bone repair materials in the clinic, how to better combine tricalcium phosphate and calcium sulfate and play their greatest advantages in the repair of osteoporotic bone defect is the focus of our research. In this study, a series of scaffolds with multistage-controlled degradation properties composed of strontium-doped calcium sulfate (SrCSH) and strontium-doped tricalcium phosphate microspheres (Sr-TCP) scaffolds were prepared, and their osteogenic activity, in vivo degradation and bone regeneration ability in tibia of osteoporotic rats were evaluated. In vitro studies revealed that different components of SrCSH/Sr-TCP scaffolds significantly promoted the proliferation and differentiation of MC3T3-E1 cells, which showed a good osteogenic induction activity. In vivo degradation results showed that the degradation time of composite scaffolds could be controlled in a large range (6-12 months) by controlling the porosity and phase composition of Sr-TCP microspheres. The results of osteoporotic femoral defect repair showed that when the degradation rate of scaffold matched with the growth rate of new bone, the parameters such as BMD, BV/TV, Tb.Th, angiogenesis marker CD31 and new bone formation marker OCN expression were higher, which promoted the rapid repair of osteoporotic bone defects. On the contrary, the slow degradation rate of scaffolds hindered the growth of new bone to a certain extent. This study elucidates the importance of the degradation rate of scaffolds for the repair of osteoporotic bone defects, and the design considerations can be extended to other bone repair materials, which is expected to provide new ideas for the development of tissue engineering materials in the future.

In vivo Evaluation of a Collagen Scaffold Preconditioned with Adipose-derived Mesenchymal Stem Cells Used for Bone Regeneration A histological study

2018 ◽  
Vol 55 (4) ◽  
pp. 691-695
Author(s):  
Tudor Sorin Pop ◽  
Anca Maria Pop ◽  
Alina Dia Trambitas Miron ◽  
Klara Brinzaniuc ◽  
Simona Gurzu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Bone Regeneration ◽  
Histological Study ◽  
Collagen Scaffold ◽  
Bone Defects ◽  
Collagen Scaffolds ◽  
In Vivo Evaluation ◽  
Calvarial Bone ◽  
Bone Apposition

The use of collagen scaffolds and stem cells for obtaining a tissue-engineering complex has been an important concept in promoting repair and regeneration of the bone tissue. Such units represent important steps in the development of an ideal scaffold-cell complex that would sustain new bone apposition. The aim of our study was to perform a histologic evaluation of the healing of critical-sized bone defects, using a biologic collagen scaffold with adipose-derived mesenchymal stem cells, in comparison to negative controls created in the adjacent bone. We used 16 Wistar rats and according to the study design 2 calvarial bone defects were created in each animal, one was filled with collagen seeded with adipose-derived stem cells and the other one was considered negative control. During the following month, at weekly intervals, the animals were euthanized and the specimens from bone defects were histologically evaluated. The results showed that these scaffolds were highly biocompatible as only moderate inflammation no rejection reactions were observed. Furthermore, the first signs of osseous healing appeared after two weeks accompanied by angiogenesis. Collagen scaffolds seeded with adipose-derived mesenchymal stem cells can be considered a promising treatment option in bone regeneration of large defects.

scholarly journals Biomaterial design strategies to address obstacles in craniomaxillofacial bone repair

RSC Advances ◽  
2021 ◽  
Vol 11 (29) ◽  
pp. 17809-17827
Author(s):  
Marley J. Dewey ◽  
Brendan A. C. Harley
Keyword(s):  
Bone Repair ◽  
Bone Defects ◽  
Design Strategies

There exist many challenges in the process of regenerating craniomaxillofacial bone defects, thus biomaterials must be designed to overcome these.

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