scholarly journals A Cross-Sectional Study on Potential Ovarian Volume and Related Factors in Women with Polycystic Ovary Syndrome from Infertile Couples

2021 ◽  
Vol Volume 13 ◽  
pp. 793-801
Author(s):  
Nguyen Sa Viet Le ◽  
Minh Tam Le ◽  
Nguyen Dac Nguyen ◽  
Nhu Quynh Thi Tran ◽  
Quoc Huy Vu Nguyen ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Ovary Syndrome ◽  
Related Factors ◽  
Cross Sectional ◽  
Ovarian Volume ◽  
Infertile Couples

Elevation of markers of endotoxemia in women with polycystic ovary syndrome

2020 ◽  
Vol 35 (10) ◽  
pp. 2303-2311
Author(s):  
Beata Banaszewska ◽  
Martyna Siakowska ◽  
Izabela Chudzicka-Strugala ◽  
R Jeffrey Chang ◽  
Leszek Pawelczyk ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Cross Sectional Study ◽  
Metabolic Dysfunction ◽  
Sectional Study ◽  
Ovary Syndrome ◽  
Cross Sectional ◽  
Volume Number ◽  
Ovarian Volume ◽  
Hs Crp

Abstract STUDY QUESTION Is polycystic ovary syndrome (PCOS) associated with an elevation of markers of endotoxemia? SUMMARY ANSWER In women with PCOS serum levels of lipopolysaccharides (LPS), the LPS to high-density lipoprotein (HDL) ratio and LPS-binding protein (LBP) are significantly greater than those of normal control subjects. WHAT IS KNOWN ALREADY Mononuclear cells from women with PCOS respond excessively to LPS by releasing pro-inflammatory cytokines. In rat ovarian theca-interstitial cell cultures LPS stimulates androgen production. STUDY DESIGN, SIZE, DURATION Cross-sectional study comparing markers of endotoxemia in women with PCOS (n = 62), healthy ovulatory women with polycystic ovary morphology (PCOM, n = 39) and a control group of healthy ovulatory women without PCOM [normal (NL), n = 43]. PARTICIPANTS/MATERIALS, SETTING, METHODS LPS was measured using a chromogenic assay. LBP was measured by ELISA. Total cholesterol and lipids were measured using a homogeneous enzyme colorimetric method. Androgens, gonadotrophins, prolactin, insulin, high-sensitivity C-reactive protein (hs-CRP) and sex hormone-binding globulin were determined by electrochemiluminescence assays. Glucose was measured using an enzymatic reference method with hexokinase. MAIN RESULTS AND THE ROLE OF CHANCE Women with PCOS, when compared with NL subjects, had a significantly higher mean LPS (P = 0.045), LPS/HDL ratio (P = 0.007) and LBP (P = 0.01). Women with PCOM had intermediate levels of markers of endotoxemia. Comparison among all groups revealed that markers of endotoxemia correlated positively with testosterone level, ovarian volume, number of antral follicles and hirsutism score, but negatively with the number of spontaneous menses per year. In multiple regression analysis, all measures of endotoxemia correlated independently and positively with hs-CRP and with ovarian volume. LIMITATIONS, REASONS FOR CAUTION This cross-sectional study reveals that markers of endotoxemia are associated with several clinical features observed in women with PCOS. However, responsible mechanisms and causation remain unknown. Steroid quantification was carried out by electrochemiluminescence assays and not by the current gold standard: liquid chromatography-mass spectrometry. Hence, the relationship of endotoxemia with features of PCOS and the extent to which endotoxemia contributes to reproductive and metabolic dysfunction warrants further investigation. WIDER IMPLICATIONS OF THE FINDINGS This study reveals the novel observation that markers of endotoxemia are elevated in young and otherwise healthy women with PCOS without significant metabolic dysfunction. Moreover, the association of clinical and endocrine markers of PCOS with those of endotoxemia may represent a pathophysiologic link to reproductive dysfunction as well as metabolic and long-term cardiovascular risks associated with this disorder. STUDY FUNDING/COMPETING INTEREST(S) Intramural funding from Poznan University of Medical Sciences. The authors have no conflicts of interest to declare. TRIAL REGISTRATION NUMBER N/A

scholarly journals The effects of obesity and polycystic ovary syndrome on serum lipocalin-2 levels: a cross-sectional study

2010 ◽  
Vol 8 (1) ◽  
pp. 151 ◽  
Author(s):  
Dimitrios Panidis ◽  
Konstantinos Tziomalos ◽  
Ekaterini Koiou ◽  
Eleni A Kandaraki ◽  
Elena Tsourdi ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Cross Sectional Study ◽  
Lipocalin 2 ◽  
Sectional Study ◽  
Ovary Syndrome ◽  
Cross Sectional

Cross‐sectional study of the prevalence of polycystic ovary syndrome in rural and urban populations

2019 ◽  
Vol 146 (3) ◽  
pp. 370-379 ◽  
Author(s):  
Ritu Deswal ◽  
Smiti Nanda ◽  
Veena S. Ghalaut ◽  
Prasanta S. Roy ◽  
Amita S. Dang
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Ovary Syndrome ◽  
Cross Sectional ◽  
Urban Populations ◽  
Rural And Urban

scholarly journals Disordered Eating Behaviours and Eating Disorders in Women in Australia with and Without Polycystic Ovary Syndrome: A Cross-Sectional Study

2019 ◽  
Vol 8 (10) ◽  
pp. 1682 ◽  
Author(s):  
Stephanie Pirotta ◽  
Mary Barillaro ◽  
Leah Brennan ◽  
Angela Grassi ◽  
Yvonne Jeanes ◽  
...  
Keyword(s):  
Eating Disorders ◽  
Eating Disorder ◽  
Polycystic Ovary Syndrome ◽  
Disordered Eating ◽  
Polycystic Ovary ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Eating Behaviours ◽  
Ovary Syndrome ◽  
Cross Sectional

Psychological co-morbidities common in polycystic ovary syndrome (PCOS) may contribute to disordered eating and subsequent weight gain. This cross-sectional study aimed to determine the prevalence of disordered eating and a range of eating disorders and demographic risk factors associated with these behaviours within an Australian group of women with and without PCOS. Data from 899 women with (n = 501) and without (n = 398) PCOS were analysed as possibly indicative of disordered eating or eating disorders using the Eating Disorder Examination Questionnaire (EDE-Q) and The Diagnostic and Statistical Manual of Mental Disorders Fifth Edition (DSM-5) criteria. Disordered eating (p = 0.012) but not eating disorders (p = 0.076) were more prevalent in women with PCOS compared to controls. Increased body mass index (BMI) [Odds Ratio (OR): 1.03; 95%; Confidence Interval (CI): 1.01, 1.05, p = 0.012] and older age [OR: 1.05; 95%CI: 1.02, 1.08, p = 0.002] but not PCOS diagnosis [OR: 1.43; 95%CI: 0.96, 2.13 p = 0.078] increased the odds of disordered eating. Increased BMI [OR: 1.04; 95%CI: 1.02, 1.06, p < 0.001] and younger age [OR: -0.95; 95%CI: 0.93–0.95, p < 0.001] but not PCOS diagnosis [OR: 1.38; 95%CI: 0.97, 1.95, p = 0.076] increased the odds of an eating disorder. Clinicians are recommended to screen all women with PCOS for possible disordered eating behaviours, with particular attention to women with elevated BMI.

Diagnosis experiences of adolescents with polycystic ovary syndrome: Cross‐sectional study

2021 ◽  
Author(s):  
Alexia S. Peña ◽  
Helena Teede ◽  
Erandi Hewawasam ◽  
Mary Louise Hull ◽  
Melanie Gibson‐Helm
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Ovary Syndrome ◽  
Cross Sectional
Sign in / Sign up

Export Citation Format

Share Document