Systematic Review of Systemic and Neuraxial Effects of Acetaminophen in Preclinical Models of Nociceptive Processing

Autism spectrum disorder (ASD) is a complex set of neurodevelopmental pathologies characterized by impoverished social and communicative abilities and stereotyped behaviors. Although its genetic basis is unquestionable, the involvement of environmental factors such as exposure to pesticides has also been proposed. Despite the systematic analyses of this relationship in humans, there are no specific reviews including both human and preclinical models. The present systematic review summarizes, analyzes, and discusses recent advances in preclinical and epidemiological studies. We included 45 human and 16 preclinical studies. These studies focused on Organophosphates (OP), Organochlorine (OC), Pyrethroid (PT), Neonicotinoid (NN), Carbamate (CM), and mixed exposures. Preclinical studies, where the OP Chlorpyrifos (CPF) compound is the one most studied, pointed to an association between gestational exposure and increased ASD-like behaviors, although the data are inconclusive with regard to other ages or pesticides. Studies in humans focused on prenatal exposure to OP and OC agents, and report cognitive and behavioral alterations related to ASD symptomatology. The results of both suggest that gestational exposure to certain OP agents could be linked to the clinical signs of ASD. Future experimental studies should focus on extending the analysis of ASD-like behaviors in preclinical models and include exposure patterns similar to those observed in human studies.

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Assessment of safety and efficacy of mesenchymal stromal cell therapy in preclinical models of acute myocardial infarction: a systematic review protocol

Systematic Reviews ◽

10.1186/s13643-017-0601-9 ◽

2017 ◽

Vol 6 (1) ◽

Cited By ~ 4

Author(s):

Carly C. Barron ◽

◽

Manoj M. Lalu ◽

Duncan J. Stewart ◽

Dean Fergusson ◽

...

Keyword(s):

Myocardial Infarction ◽

Systematic Review ◽

Acute Myocardial Infarction ◽

Cell Therapy ◽

Mesenchymal Stromal Cell ◽

Stromal Cell ◽

Systematic Review Protocol ◽

Preclinical Models ◽

Safety And Efficacy ◽

Review Protocol

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Investigating the blood–spinal cord barrier in preclinical models: a systematic review of in vivo imaging techniques

Spinal Cord ◽

10.1038/s41393-021-00623-7 ◽

2021 ◽

Author(s):

Joshua Bakhsheshian ◽

Ben A. Strickland ◽

William J. Mack ◽

Berislav V. Zlokovic

Keyword(s):

Systematic Review ◽

Spinal Cord ◽

In Vivo Imaging ◽

Imaging Techniques ◽

Preclinical Models ◽

Blood Spinal Cord Barrier

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Efficacy of mesenchymal stromal cells in preclinical models of necrotizing enterocolitis: a systematic review protocol

F1000Research ◽

10.12688/f1000research.73094.1 ◽

2021 ◽

Vol 10 ◽

pp. 1011

Author(s):

Camille Maltais-Bilodeau ◽

Ewa Henckel ◽

Kelly D. Cobey ◽

Nadera Ahmadzai ◽

Becky Skidmore ◽

...

Keyword(s):

Systematic Review ◽

Animal Models ◽

Necrotizing Enterocolitis ◽

Mesenchymal Stromal Cells ◽

Stromal Cells ◽

Bowel Perforation ◽

Risk Of Bias ◽

Sufficient Evidence ◽

Preclinical Models

Introduction: Necrotizing enterocolitis is an acute inflammatory disease of the intestine that can lead to necrosis and bowel perforation. It is a severe complication of preterm birth. It’s mortality rate is up to 50% and survival after necrotizing enterocolitis leads to long-term complications. The current treatment is supportive and includes bowel rest and decompression and antibiotics. Thus, new treatments are necessary to reduce mortality and morbidity. Mesenchymal stromal cells are known to have anti-inflammatory properties and might be a promising option for treatment. Here we present a protocol for a systematic review with the aim to explore the efficacy of cell therapies with mesenchymal stromal cells in animal models of necrotizing enterocolitis. The primary outcome is histological signs of necrotizing enterocolitis. Additional outcomes include survival, bowel perforation, gut permeability, gut motility, levels of inflammatory markers, cytokine levels and adverse events. Methods: We will conduct a systematic search of MEDLINE, Embase, and Web of Science databases. The retrieved records will be screened individually by two investigators. We will include all preclinical in vivo animal models of experimentally induced necrotizing enterocolitis that evaluate the efficacy of mesenchymal stromal cells or other cell therapy treatments. Outcome data will be extracted from each article and risk of bias assessment performed. Funnel plots and SYRCLE’s risk of bias tool for animal studies will be used. Data will be reported as ratios, divided in predefined subgroups where relevant. Conclusions: This systematic review aims to examine the efficacy of mesenchymal stromal cells in preclinical models of necrotizing enterocolitis and whether there is sufficient evidence to support a clinical trial of efficacy and safety of the treatment with mesenchymal stromal cells in infants with necrotizing enterocolitis.

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Arthrotomy-based preclinical models of particle-induced osteolysis: A systematic review

Journal of Orthopaedic Research® ◽

10.1002/jor.23619 ◽

2017 ◽

Vol 35 (12) ◽

pp. 2595-2605 ◽

Cited By ~ 9

Author(s):

Meghan M. Moran ◽

Brittany M. Wilson ◽

Ryan D. Ross ◽

Amarjit S. Virdi ◽

Dale Rick Sumner

Keyword(s):

Systematic Review ◽

Preclinical Models

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Efficacy of Mesenchymal Stromal Cells in Preclinical Models of Necrotizing Enterocolitis: a Systematic Review Protocol

10.21203/rs.3.rs-239448/v1 ◽

2021 ◽

Author(s):

Camille Maltais-Bilodeau ◽

Ewa Henckel ◽

Kelly D. Cobey ◽

Nadera Ahmadzai ◽

Becky Skidmore ◽

...

Keyword(s):

Systematic Review ◽

Animal Models ◽

Necrotizing Enterocolitis ◽

Mesenchymal Stromal Cells ◽

Stromal Cells ◽

Bowel Perforation ◽

Risk Of Bias ◽

Sufficient Evidence ◽

Preclinical Models

Abstract BackgroundNecrotizing enterocolitis is an acute inflammatory disease of the intestine that can lead to necrosis and bowel perforation. It is a severe complication of preterm birth with a prevalence of 7% in infants with a birth weight less than 1500 grams. It’s mortality rate is up to 30% and survival after necrotizing enterocolitis leads to long-term gastrointestinal and neurocognitive consequences. The current treatment is supportive and includes bowel rest and decompression and antibiotics. Thus, new treatments are necessary to reduce mortality and morbidity. Mesenchymal stromal cells are known to have anti-inflammatory properties and might be a promising option for treatment. Here we present a protocol for a systematic review with the aim to explore the efficacy of cell therapies with mesenchymal stromal cells in animal models of necrotizing enterocolitis. The primary outcome is histological signs of necrotizing enterocolitis. Additional outcomes include survival, bowel perforation, gut permeability, gut motility, levels of inflammatory markers, cytokine levels and adverse events.MethodsWe will conduct a systematic search of MEDLINE, Embase, and Web of Science databases. The retrieved records will be screened individually by two investigators. We will include all preclinical in vivo animal models of experimentally induced NEC that evaluate the efficacy of mesenchymal stromal cells or other cell therapy treatments. Outcome data will be extracted from each article and risk of bias assessment performed. Funnel plots and SYRCLE’s risk of bias tool for animal studies will be used. Data will be reported as ratios, divided in predefined subgroups where relevant. DiscussionThis systematic review aims to examine the efficacy of mesenchymal stromal cells in preclinical models of necrotizing enterocolitis and whether there is sufficient evidence to support a clinical trial of efficacy and safety of the treatment with mesenchymal stromal cells in infants with necrotizing enterocolitis.Systematic review registrationThis protocol has been registered on Open Science framework: osf.io/5rc6t

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