Correlation of central corneal thickness and axial length to the optic disc and peripapillary atrophy among healthy individuals, glaucoma and ocular hypertension patients

Purpose: To evaluate the distribution of the posterior-anterior corneal radius ratio (B/F ratio; posterior corneal radius/anterior corneal radius) in patients without corneal abnormalities, and to investigate which parameters affect this ratio. Methods: Five thousand eyes from 5,000 patients who underwent cataract surgery were recruited to this study. We explored the linear relationship between B/F ratio and 13 variables using Principal Component-Multivariate Linear Regression Analysis. Results: The B/F ratio was negatively correlated with the difference between simulated keratometry (SimK) and true net power (TNP), central corneal thickness, spherical aberration (SA), and posterior corneal astigmatism and positively correlated with posterior corneal radius, corneal posterior surface, axial length (AL) and anterior corneal radius. Several variables (central corneal thickness, difference between SimK and TNP and asphericity coefficient (Q-value) of the posterior corneal surface) had the highest loading on the final score. B/F ratio reflects the refractive state and anatomical structure of the cornea: thus, higher B/F ratios were associated with larger posterior corneal surface curvature radius, longer axial length, thinner central corneal thickness, lower high order aberrations of the cornea and SA, and the numerical difference between simK and TNP gradually reduced. In clinical practice, for patients with lower B/F ratio, special care should be taken in the choice of system used for intraocular lens (IOL) measurements.

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Comparative Results of Central Corneal Thickness Measurements in Primary Open-Angle Glaucoma, Pseudoexfoliation Glaucoma, and Ocular Hypertension

Ophthalmic Surgery Lasers and Imaging ◽

10.3928/15428877-20080101-05 ◽

2008 ◽

Vol 39 (1) ◽

pp. 17-21 ◽

Cited By ~ 4

Author(s):

Spiridon Gorezis ◽

Gartzos Christos ◽

Maria Stefaniotou ◽

Kostantinos Moustaklis ◽

Aggelos Skyrlas; Georgios Kitsos

Keyword(s):

Ocular Hypertension ◽

Central Corneal Thickness ◽

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

Corneal Thickness ◽

Open Angle ◽

Pseudoexfoliation Glaucoma ◽

Comparative Results ◽

Thickness Measurements

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To study the effects of central corneal thickness, axial length, and anterior chamber depth on intraocular pressure

Sudanese Journal of Ophthalmology ◽

10.4103/sjopthal.sjopthal_17_17 ◽

2017 ◽

Vol 9 (1) ◽

pp. 10

Author(s):

MuhammadIjaz Ahmad ◽

ManzoorAhmad Qureshi ◽

YousefHomood Aldebasi

Keyword(s):

Intraocular Pressure ◽

Anterior Chamber ◽

Axial Length ◽

Central Corneal Thickness ◽

Corneal Thickness ◽

Anterior Chamber Depth

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Early Macular Angiography among Patients with Glaucoma, Ocular Hypertension, and Normal Subjects

Journal of Ophthalmology ◽

10.1155/2019/7419470 ◽

2019 ◽

Vol 2019 ◽

pp. 1-7 ◽

Cited By ~ 5

Author(s):

Shih-Chun Chao ◽

Shang-Jung Yang ◽

Hung-Chi Chen ◽

Chi-Chin Sun ◽

Chin-Hsin Liu ◽

...

Keyword(s):

Intraocular Pressure ◽

Visual Field ◽

Ganglion Cell ◽

Ocular Hypertension ◽

Central Corneal Thickness ◽

Corneal Thickness ◽

Control Group ◽

Ganglion Cell Complex ◽

Outer Retina ◽

Flow Area

Purpose. To evaluate early macular circulation in open-angle glaucoma (OAG), normal-tension glaucoma (NTG), ocular hypertension (OHT), and healthy subjects via optical coherence tomography angiography (OCTA). Methods. A retrospective cross-sectional study was conducted. Medical records were reviewed, and the patients who received OCTA examinations were divided into the OAG, NTG, OHT, and normal groups. The ophthalmic data including best-corrected visual acuity, spherical equivalent, intraocular pressure, central corneal thickness, central foveal thickness, visual field deviation, retinal nerve fiber layers thickness, and ganglion cell complex thickness were obtained from medical documents. For the macular area, the superficial vessel density (VD), deep VD, foveal avascular zone (FAZ), flow area of the outer retina, and flow area of the choriocapillaris were measured via OCTA and analyzed using the default vascular density analysis program in the same OCTA device. Results. A total of 70 eyes from 70 patients were analyzed in the current study. Significant differences in the intraocular pressure, central corneal thickness, visual field deviation, retinal fiber layer thickness, and ganglion cell complex thickness were observed in the patients in the glaucoma group at their last visits. The OAG and NTG groups evinced a lower superficial VD than did the control group, while the NTG group had a lower deep VD than the control group. The NTG group also had a larger FAZ than did the OHT group. The flow area of the outer retina in the OAG group was low relative to those of the OHT and control groups. No difference in choriocapillaris perfusion was observed among the groups. Conclusion. The OAG and NTG patients demonstrated impaired vasculature before significant disease development could be observed. Furthermore, the differences in macular circulation may be associated with differences in the courses of disease between the glaucoma and OHT patients.

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The comparative study of two recently developed A-scan devices: determination of central corneal thickness, anterior chamber depth and axial length

Acta Ophthalmologica ◽

10.1111/j.1600-0420.2007.00994.x ◽

2008 ◽

Vol 86 (1) ◽

pp. 45-48 ◽

Cited By ~ 4

Author(s):

Zoltán Sohajda ◽

Júlia Papp ◽

András Berta ◽

László Módis

Keyword(s):

Comparative Study ◽

Anterior Chamber ◽

Axial Length ◽

Central Corneal Thickness ◽

Corneal Thickness ◽

Anterior Chamber Depth ◽

The Comparative Study

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Effects of SMILE Surgery on Intraocular Pressure, Central Corneal Thickness, Axial Length, Peripapillary Retinal Nerve Fiber Layer, and Macular Ganglion Cell Complex Thickness

Journal of Ophthalmology ◽

10.1155/2020/4934196 ◽

2020 ◽

Vol 2020 ◽

pp. 1-6

Author(s):

Zhanlin Zhao ◽

Sylvain Michée ◽

Jean-François Faure ◽

Christophe Baudouin ◽

Antoine Labbé

Keyword(s):

Intraocular Pressure ◽

Ganglion Cell ◽

Nerve Fiber ◽

Axial Length ◽

Central Corneal Thickness ◽

Corneal Thickness ◽

Ganglion Cell Complex ◽

Fiber Layer ◽

Rnfl Thickness ◽

The Mean

Purpose. To evaluate the change in intraocular pressure (IOP), central corneal thickness (CCT), axial length, peripapillary retinal nerve fiber layer (RNFL) thickness, and macular ganglion cell complex (GCC) thickness after small incision lenticule extraction (SMILE) surgery. Methods. This prospective observational study was conducted in Espace Nouvelle Vision, Ophthalmological Clinic, Paris, France. Fifty eyes of 25 patients were enrolled in this study and underwent SMILE surgeries. IOP, central corneal thickness (CCT), axial length (AL), peripapillary RNFL thickness, and macular GCC thickness were measured before and at 3 months after SMILE. Results. The mean preoperative spherical equivalent was −3.15 ± 1.50 diopters (D), and the mean postoperative value was 0.15 ± 0.28 D. After SMILE surgery, IOP decreased from 15.03 ± 2.79 mmHg to 11.02 ± 2.73 mmHg and 10.02 ± 2.21 mmHg at 1 and 3 months, respectively ( P < 0.01 for both comparisons). The mean decrease in measured IOP as a function of ablation depth was 0.065 ± 0.031 mmHg/μm. CCT decreased from 545.98 ± 26.61 μm to 478.40 ± 30.26 μm after SMILE surgery ( P < 0.01 ). AL decreased from 24.80 ± 0.84 mm to 24.70 ± 0.83 mm ( P < 0.01 ). There was no statistically significant change in mean peripapillary RNFL or mean GCC thickness after SMILE surgery. Conclusions. SMILE surgery modified IOP measurement, CCT, and AL but did not change peripapillary RNFL and macular GCC thicknesses. The postoperative drop in measured IOP might be explained by the decreased CCT. An accurate re-evaluation of AL should be performed before cataract surgery among post-SMILE patients.

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