<p>KNDC1 Is a Predictive Marker of Malignant Transformation in Borderline Ovarian Tumors</p>

ObjectivesSince the recognition of borderline ovarian tumors (BOTs) in the 1970s, the management of this subset of epithelial ovarian tumors has presented a challenge to clinicians. The majority present at an early stage, but their diagnosis is often only made following surgery, hence the heterogeneity of surgical management. Borderline ovarian tumors are morphologically diverse, and their behavior is subsequently also heterogeneous. We aimed to assess recurrence rates and the rate of malignant transformation in patients diagnosed with BOT. Secondary objectives included a review of current management and assessment of tumor markers, stage, cyst dimensions, and the presence of micropapillary features as prognostic indicators of recurrence.MethodsThis retrospective cohort study included all patients treated with BOT between 2000 and 2015 in the southeast region of Scotland. Clinical, surgicopathological, and follow-up data were collated. Data were analyzed with reference to recurrence and malignant transformation.ResultsTwo hundred seventy-five patients underwent treatment for BOT in the study period. Surgical management was highly variable. A diagnosis of recurrent/persistent BOT or ovarian malignancy following initial treatment of BOT was rare, with only 12 (4%) of 275 cases. There were 7 cases (3%) of ovarian malignancy. Advanced International Federation of Gynecology and Obstetrics stage was the most prominent prognostic factor. Elevated preoperative serum CA-125 and the presence of micropapillary features correlated with advanced stage at presentation. With a lack of clear guidance, follow-up was highly variable with a median of 43 months (0–136 months).ConclusionsTo our knowledge, this study is the largest BOT cohort in the United Kingdom. Recurrent disease is rare in optimally staged, completely resected, early-stage BOT, without high-risk features. Caution is needed in women electing not to undergo completion staging after diagnosis and in those opting for a fertility-preserving approach. Thorough informed consent and clear plans for surveillance and follow-up are needed with consideration of delayed completion surgery as appropriate.

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Management of Borderline Ovarian Tumors (BOT): results of a retrospective, single center study in Switzerland

10.1055/s-0040-1718202 ◽

2020 ◽

Author(s):

B Kipp ◽

A Vidal ◽

C Braun ◽

C Christmann

Keyword(s):

Ovarian Tumors ◽

Single Center ◽

Borderline Ovarian Tumors ◽

Single Center Study ◽

Center Study

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Assessment of lymphocyte iNKT+/CD3+/CD161+ in blood and tumor tissue in cases of benign ovarian tumors, borderline ovarian tumors and advanced-stage ovarian carcinomas

10.26226/morressier.597eedbad462b80296ca1465 ◽

2017 ◽

Author(s):

Winkler Izabela

Keyword(s):

Tumor Tissue ◽

Ovarian Tumors ◽

Advanced Stage ◽

Ovarian Carcinomas ◽

Borderline Ovarian Tumors ◽

Benign Ovarian Tumors

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Salpingo-oophorectomy versus cystectomy in patients with borderline ovarian tumors: a systemic review and meta-analysis on postoperative recurrence and fertility

World Journal of Surgical Oncology ◽

10.1186/s12957-021-02241-2 ◽

2021 ◽

Vol 19 (1) ◽

Author(s):

Peng Wang ◽

Lei Fang

Keyword(s):

Surgical Procedures ◽

Postoperative Recurrence ◽

Pregnancy Rates ◽

Ovarian Tumors ◽

Systemic Review ◽

Cochrane Library ◽

Risk Of Recurrence ◽

Borderline Ovarian Tumors ◽

Surgical Methods ◽

Meta Analyses

Abstract Background To compare the postoperative recurrence and fertility in patients with borderline ovarian tumors (BOTs) who underwent different surgical procedures: salpingo-oophorectomy versus cystectomy. Methods Potentially relevant literature from inception to Nov. 06, 2020, were retrieved in databases including Cochrane Library, EMBASE (Ovid), and MEDLINE (Pubmed). We applied the keywords “fertility-sparing surgery,” or “conservative surgery,” or “cystectomy,” or “salpingo-oophorectomy,” or “oophorectomy,” or “adnexectomy,” or “borderline ovarian tumor” for literate searching. Systemic reviews and meta-analyses were performed on the postoperative recurrence rates and pregnancy rates between patients receiving the two different surgical methods. Begger’s methods, Egger’s methods, and funnel plot were used to evaluate the publication bias. Result Among the sixteen eligible studies, the risk of recurrence was evaluated in all studies, and eight studies assessed the postoperative pregnancy rates in the BOT patients. A total of 1839 cases with borderline ovarian tumors were included, in which 697 patients (37.9%) received unilateral salpingo-oophorectomy and 1142 patients (62.1%) underwent unilateral/bilateral cystectomy. Meta-analyses showed that BOT patients with unilateral/bilateral cystectomy had significantly higher recurrence risk (OR=2.02, 95% CI: 1.59-2.57) compared with those receiving unilateral salpingo-oophorectomy. Pooled analysis of four studies further confirmed the higher risk of recurrence in patients with cystectomy (HR=2.00, 95% CI: 1.11-3.58). In addition, no significant difference in postoperative pregnancy rate was found between patients with the two different surgical procedures (OR=0.92, 95% CI: 0.60-1.42). Conclusion Compared with the unilateral/bilateral cystectomy, the unilateral salpingo-oophorectomy significantly reduces the risk of postoperative recurrence in patients with BOT, and it does not reduce the pregnancy of patients after surgery. Trial registration PROSPERO CRD42021238177

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Ovulation induction treatment and risk of borderline ovarian tumors

Gynecological Endocrinology ◽

10.1080/09513590701350341 ◽

2007 ◽

Vol 23 (7) ◽

pp. 373-376 ◽

Cited By ~ 23

Author(s):

Maite Cusidó ◽

Rafael Fábregas ◽

Pere Barris S ◽

Cecilia Escayola ◽

Pere Nolsac Barri

Keyword(s):

Ovulation Induction ◽

Ovarian Tumors ◽

Induction Treatment ◽

Borderline Ovarian Tumors

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Influence of lymph node involvement or lymphadenectomy on prognosis of patients with borderline ovarian tumors: A systematic review and meta-analysis

Gynecologic Oncology ◽

10.1016/j.ygyno.2021.05.033 ◽

2021 ◽

Author(s):

Yu Fan ◽

Yu-fei Zhang ◽

Meng-yao Wang ◽

Yi Mu ◽

Si-ping Mo ◽

...

Keyword(s):

Systematic Review ◽

Lymph Node ◽

Meta Analysis ◽

Lymph Node Involvement ◽

Ovarian Tumors ◽

Borderline Ovarian Tumors ◽

Node Involvement

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Minimally invasive treatment options to borderline ovarian tumors

10.1055/s-0039-1685392 ◽

2016 ◽

Author(s):

Punita Bhardwaj ◽

T. K. Das ◽

S. Batra ◽

Keyword(s):

Early Stage ◽

Treatment Options ◽

Malignant Potential ◽

Ovarian Tumors ◽

Conservative Approach ◽

Uncertain Malignant Potential ◽

Invasive Treatment ◽

Younger Women ◽

Borderline Ovarian Tumors

Borderline Ovarian tumors are tumors of uncertain malignant potential. They have favour able prognosis. They occur in younger women and present at an early stage. They are difficult to diagnose preoperatively as macroscopic picture is a combination of benign and invasive ovarian tumors. Over the years surgical treatment has changed from radical to conservative approach without overlooking oncologic safety. Follows up is essential. Prolonged follow up (>10 yrs) is required because of later recurrences. Special attention is to be paid to the conserved ovary in follow up.

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