scholarly journals Patient Satisfaction And Disease Control In Patients With Systemic Lupus Erythematosus Is Not Affected By Switching From Intravenous Belimumab To Subcutaneous Injections

2019 ◽  
Vol Volume 13 ◽  
pp. 1889-1894 ◽  
Author(s):  
Johanna Mucke ◽  
Ralph Brinks ◽  
Rebecca Fischer-Betz ◽  
Jutta G Richter ◽  
Oliver Sander ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Patient Satisfaction ◽  
Disease Control ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Subcutaneous Injections

Restrictive Use of Oral Glucocorticoids in Systemic Lupus Erythematosus and Prevention of Damage Without Worsening Long-Term Disease Control: An Observational Study

2018 ◽  
Vol 70 (4) ◽  
pp. 582-591 ◽  
Author(s):  
Ioana Ruiz-Arruza ◽  
Jesús Lozano ◽  
Ivan Cabezas-Rodriguez ◽  
Jose-Alejandro Medina ◽  
Amaia Ugarte ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Observational Study ◽  
Disease Control ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Oral Glucocorticoids

scholarly journals Phase III, multicentre, randomised, double-blind, placebo-controlled, 104-week study of subcutaneous belimumab administered in combination with rituximab in adults with systemic lupus erythematosus (SLE): BLISS-BELIEVE study protocol

BMJ Open ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. e025687 ◽  
Author(s):  
Y K Onno Teng ◽  
Ian N Bruce ◽  
Betty Diamond ◽  
Richard A Furie ◽  
Ronald F van Vollenhoven ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Disease Control ◽  
Lupus Erythematosus ◽  
B Lymphocyte ◽  
Activity Index ◽  
Phase Iii ◽  
Systemic Lupus ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Link Type

IntroductionBelimumab, an anti-B-lymphocyte-stimulator antibody, is approved for the treatment of active, autoantibody-positive systemic lupus erythematosus (SLE). Rituximab, a B cell-depleting anti-CD20 antibody, remains in the SLE treatment armamentarium despite failed trials in lupus nephritis and extrarenal lupus. These biologics, which operate through complementary mechanisms, might result in an enhanced depletion of circulating and tissue-resident autoreactive B lymphocytes when administered together. Thus, belimumab and rituximab combination may be a highly effective treatment of SLE. This study aims to evaluate and compare the efficacy, safety and tolerability of subcutaneous (SC) belimumab and a single cycle of rituximab in patients with SLE with belimumab alone.Methods and analysisBLISS-BELIEVE is a three-arm, randomised, double-blind, placebo-controlled, 104-week superiority study. Two hundred adults with SLE will be randomised 1:2:1 to arm A, belimumab SC 200 mg/week for 52 weeks plus placebo at weeks 4 and 6; arm B, belimumab SC 200 mg/week for 52 weeks plus rituximab 1000 mg at weeks 4 and 6; arm C, belimumab SC 200 mg/week plus standard of care for 104 weeks. The 52-week treatment period (arms A and B) is followed by a 52-week observational phase. The primary efficacy endpoint is the proportion of patients with disease control (SLE Disease Activity Index (SLEDAI)−2K≤2, without immunosuppressants and with a prednisone-equivalent dose of ≤5 mg/day) at week 52. Major secondary efficacy endpoints are the proportion of patients in clinical remission (defined as SLEDAI-2K=0, without immunosuppressants and corticosteroids) at week 64, and the proportion of patients with disease control at week 104. Safety endpoints include the incidence of adverse events (AEs), serious AEs and AEs of special interest.Ethics and disseminationWithin 6 months of the study’s primary manuscript publication, anonymised individual participant data and study documents can be requested for further research fromwww.clinicalstudydatarequest.com.Trial registration numberNCT03312907; Pre-results.

Comprehensive disease control in systemic lupus erythematosus

2021 ◽  
Vol 51 (2) ◽  
pp. 404-408
Author(s):  
Fulvia Ceccarelli ◽  
Giulio Olivieri ◽  
Alessio Sortino ◽  
Lorenzo Dominici ◽  
Filmon Arefayne ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Disease Control ◽  
Lupus Erythematosus ◽  
Systemic Lupus

scholarly journals AB0467 IMPROVED DISEASE CONTROL OF SYSTEMIC LUPUS ERYTHEMATOSUS AND ITS POSSIBLE ASSOCIATION WITH AGGRESSIVE USE OF IMMUNOSUPPRESSANTS

2019 ◽  
Author(s):  
Chihiro Imaizumi ◽  
Yuki Inoue ◽  
Takaharu Kagtagiri ◽  
Sayaka Takenaka ◽  
Hideki Ito ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Disease Control ◽  
Lupus Erythematosus ◽  
Systemic Lupus
Sign in / Sign up

Export Citation Format

Share Document