scholarly journals A new algorithm of treatment choice in primary open-angle glaucoma

2021 ◽  
Vol 14 (4) ◽  
pp. 7-17
Author(s):  
A. A. Antonov ◽  
I. V. Kozlova ◽  
A. A. Vitkov ◽  
T. M. Agadzhanyan
Keyword(s):  
Surgical Treatment ◽  
Real Time ◽  
Patient Management ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Ophthalmological Examination ◽  
Open Angle ◽  
Point Scale ◽  
Optimal Method ◽  
Hypotensive Therapy

Purpose: to develop a comprehensive algorithm for choosing the optimal method for monitoring and treating patients with primary openangle glaucoma (POAG). Material and methods. 30 patients with POAG, aged 30 to 86, underwent an ophthalmological examination which included visometry, standard automatic perimetry, tonometry, ophthalmoscopy, and biomicroscopy. The data obtained were evaluated on a point scale according to the innovative algorithm, on the basis of which a plan of patient management was recommended. Then the recommendation of the algorithm was compared with the suggestion of an expert specializing in the treatment of glaucoma. Results. The proposed innovative algorithm for treating POAG patients sets up four stages in the appointment of topical hypotensive therapy. When gaining a certain number of points, the algorithm recommends surgical treatment. The treatment tactics suggested by the algorithm, agreed with the opinion of glaucoma expert in most of the cases (27 out of 30 cases; 90%). Conclusion. An algorithm for the treatment of patients with POAG has been proposed and tested. The algorithm makes it possible to assess the progression of the glaucomatous process and select the optimal tactics for managing the patient in real time of examination.

Surgical resection of the sclera is a non-penetrating operation for the treatment of patients with primary open-angle and secondary glaucoma

GlaucomaNews ◽  
2020 ◽  
pp. 62-65
Author(s):  
А.Y. Kazantseva ◽  
◽  
O.A. Rumyantseva ◽  
Keyword(s):  
Surgical Resection ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Secondary Glaucoma ◽  
Ophthalmological Examination ◽  
Open Angle ◽  
Visual Functions ◽  
Dynamic Observation ◽  
Uveoscleral Outflow ◽  
Outflow Pathway

Purpose. To evaluate the effectiveness of surgical resection of the sclera in patients with primary open-angle and secondary glaucoma. Materials and methods. The study included 84 patients with POAG and SG stages III-IV and decompensated IOP level (not higher than 32 mm Hg). In order to normalize the increased ophthalmotonus, a non - penetrating operation was performed-surgical resection of the sclera (SRS). The patients underwent complex ophthalmological examination and dynamic observation. Result. In the studied groups of patients after surgical treatment there was a decrease in elevated IOP levels by 33.42%, an improvement in the coefficient of ease of outflow and a weakening of the hypotensive regime. Stabilization of visual functions was observed in all patients. Summary. The proposed new SRS technique provides a smooth decrease in IOP, preservation of visual functions and is not accompanied by intra-and postoperative complications. Key words: primary open-angle glaucoma, surgical resection of sclera, secondary glaucoma, uveoscleral outflow pathway (USPO), intraocular pressure, EO coefficient .

Outcomes of Surgical Treatment for Primary Open-Angle Glaucoma

1996 ◽  
pp. 283-290
Author(s):  
J. Caprioli ◽  
K. Nouri-Mahdavi ◽  
L. Brigatti ◽  
M. Weitzman
Keyword(s):  
Surgical Treatment ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Open Angle

Hypotensive therapy in patients with primary open-angle glaucoma

2013 ◽  
pp. 869-874 ◽  
Author(s):  
Beata Krasińska ◽  
Jarosław Kocięcki ◽  
Zbigniew Krasiński ◽  
Andrzej Tykarski
Keyword(s):  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Open Angle ◽  
Hypotensive Therapy

Surgical resection of the sclera is a non-penetrating operation for the treatment of patients with primary open-angle and secondary glaucoma

GlaucomaNews ◽  
2020 ◽  
pp. 59-61
Author(s):  
А.Y. Kazantseva ◽  
◽  
O.A. Rumyantseva ◽  
Keyword(s):  
Surgical Resection ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Secondary Glaucoma ◽  
Ophthalmological Examination ◽  
Open Angle ◽  
Visual Functions ◽  
Dynamic Observation ◽  
Uveoscleral Outflow ◽  
Outflow Pathway

Purpose. To evaluate the effectiveness of surgical resection of the sclera in patients with primary open-angle and secondary glaucoma. Materials and methods. The study included 84 patients with POAG and SG stages III-IV and decompensated IOP level (not higher than 32 mm Hg). In order to normalize the increased ophthalmotonus, a non - penetrating operation was performed-surgical resection of the sclera (SRS). The patients underwent complex ophthalmological examination and dynamic observation. Result. In the studied groups of patients after surgical treatment there was a decrease in elevated IOP levels by 33.42%, an improvement in the coefficient of ease of outflow and a weakening of the hypotensive regime. Stabilization of visual functions was observed in all patients. Summary. The proposed new SRS technique provides a smooth decrease in IOP, preservation of visual functions and is not accompanied by intra-and postoperative complications. Key words: primary open-angle glaucoma, surgical resection of sclera, secondary glaucoma, uveoscleral outflow pathway (USPO), intraocular pressure, EO coefficient .

The efficacy of maximum hypotensive therapy with fixed dose combinations in primary open-angle glaucoma

2016 ◽  
Vol 16 (4) ◽  
pp. 181-184
Author(s):  
A.E. Babushkin ◽  
◽  
O.I. Orenburkina ◽  
E.N. Matyukhina ◽  
◽  
...  
Keyword(s):  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Fixed Dose ◽  
Open Angle ◽  
Hypotensive Therapy

Study of the effectiveness of osteopathic correction in the complex treatment of patients with operated primary open-angle glaucoma

2021 ◽  
pp. 66-76
Author(s):  
O. V. Zubkov ◽  
E. A. Smirnova ◽  
V. V. Kramar ◽  
O. I. Kurbatov
Keyword(s):  
Visual Acuity ◽  
Intraocular Pressure ◽  
Surgical Treatment ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Pain Syndrome ◽  
Open Angle ◽  
Complex Treatment ◽  
Fiber Layer ◽  
Complex Therapy

Introduction. Glaucoma is a chronic eye disease characterized by a constant or periodic increase in intraocular pressure, a decrease of visual fields and visual acuity, and by a special form of optic nerve atrophy with excavation in the disc area. The reflection of this slowly fl owing atrophy is a disturbance in the visual field and a complete irreversible loss of visual function. The prevalence of the disease increases with increasing age. The main methods of treatment are medical and surgical. Non-penetrating operations are recognized as the safest methods of surgical treatment of glaucoma. The most common complications of such operations include: detachment of the choroid, small anterior chamber syndrome, hyphema, cicatricial changes in the filtration cushion. Based on the analysis of literature data, it can be assumed that the inclusion of osteopathic correction in the complex therapy of patients with operated glaucoma can increase the effectiveness of therapy.The aim of the research was to study the clinical efficacy of osteopathic correction in the complex treatment of patients operated on primary open-angle glaucoma.Materials and methods. The study involved 20 patients (20 eyes) aged 70 to 75 years with developed and advanced stages of primary open-angle glaucoma, who underwent surgical treatment. The main (10 people) and control (10 people) groups were formed by simple randomization. Participants in the main group received standard medical therapy and osteopathic correction, while participants in the control group received only medical therapy. Changes in the following clinical parameters were evaluated: visual acuity, visual fi eld, intraocular pressure, thickness of the retinal nerve fiber layer, and severity of pain syndrome. Indicators were recorded at the beginning of the study (2 weeks after surgery) and at the end of the study (2–3 months after surgery).Results. Patients receiving osteopathic correction as part of the complex therapy after surgery of primary openangle glaucoma are characterized by a statistically significant (p<0,05) decrease in the severity of pain syndrome, an increase in the magnitude of the visual field and of the thickness of the retinal nerve fiber layer.Conclusion. The obtained results suggest the effectiveness of the inclusion of osteopathic correction in the complex treatment of patients with operated on primary open-angle glaucoma. It is recommended to continue the study with a larger sample size.

scholarly journals An evaluation of ocular elasticity using real-time ultrasound elastography in primary open-angle glaucoma

2016 ◽  
Vol 89 (1060) ◽  
pp. 20150429 ◽  
Author(s):  
Kadir Agladioglu ◽  
Gökhan Pekel ◽  
Seher Altintas Kasikci ◽  
Ramazan Yagci ◽  
Yilmaz Kiroglu
Keyword(s):  
Real Time ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Ultrasound Elastography ◽  
Open Angle

Real-Time Ultrasound Elastographic Features of Primary Open Angle Glaucoma

2016 ◽  
Vol 32 (4) ◽  
pp. 333-337 ◽  
Author(s):  
Ozlem Unal ◽  
Nurdan Cay ◽  
Fatma Yulek ◽  
Ayse Guzin Taslipinar ◽  
Selen Bozkurt ◽  
...  
Keyword(s):  
Real Time ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Open Angle

scholarly journals The Potential Role of Long Noncoding RNAs in Primary Open-Angle Glaucoma

2019 ◽  
Author(s):  
Feng Zhang ◽  
Yang Zhao ◽  
Mengdan Cao ◽  
Xu Jia ◽  
Zheng Pan ◽  
...  
Keyword(s):  
Real Time ◽  
Quantitative Pcr ◽  
Noncoding Rna ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Expression Profiles ◽  
Open Angle ◽  
Real Time Quantitative Pcr ◽  
Microarray Analyses ◽  
Normal Controls

Abstract Background To identify the potential genes in human trabecular meshwork (TM) related to primary open-angle glaucoma (POAG). At first, long noncoding RNA (LncRNA) and mRNA expression profiles in TM samples from 4 control subjects and POAG patients were accessed by microarray analyses. Then, twenty lncRNAs were validated by real-time quantitative PCR in the same samples from microarray analyses. Finally, eight highly expression lncRNAs were further tested by real-time quantitative PCR in TM from 8 normal controls and 19 POAG patients. Expression data were normalized and analyzed using the R software. Pathway analyses were performed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis.Results: A total of 2179 lncRNAs and 923 mRNAs in the TM of POAG patients were significantly up-regulated, and 3111 lncRNAs and 887 mRNAs were significantly down-regulated. ENST00000552367, ENST00000582505, ENST00000609130, NR_029395, NR_038379, and ENST00000586949 expression levels were significantly higher in the TM from a different cohort of POAG patient than normal controls.Conclusion: ENST00000552367, ENST00000582505, ENST000006091- 30, NR_029395, NR_038379, and ENST00000586949 may play essential roles in the development of POAG.

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