The efficacy of maximum hypotensive therapy with fixed dose combinations in primary open-angle glaucoma

Background: Primary open angle glaucoma remains a high magnitude healthcare problem due to its prevalence and chronicity. The real world scenario of anti glaucoma medical therapy needs periodical auditing as far as drug prescriptions are concerned for formulation of treatment guidelines. Few studies from India have taken a longitudinal approach in this respect. This study was undertaken to identify such lacunae.Methods: This was an open label, prospective, observational study. Each treatment naive patient was followed up for a period of 6 months, where their prescriptions were scanned for the type of the anti glaucoma medications, total number of medications, route of administration, their duration of use and their frequency of dosage and change in medications if any, in each visits.Results: A gradual shift from monotherapy towards combination therapy was observed. Overall averages for prescriptions were topped by monotherapy at 44.25 followed by fixed dose combinations at 38.25, and then combination-polytherapy at 36 and the least number of prescriptions were for concurrent polytherapy at 17.5. Amongst all monotherapy agents, beta blockers were the most frequently prescribed drugs at baseline but their share of prescriptions was almost halved at the end of our study. The prostaglandin analogs on the other hand saw an upsurge in prescriptions from their baseline to the end of this study. Prostaglandin analogs andbeta blockers as fixed dose combination was a popular prescription over the entire study duration.Conclusions: Prescribing trends were remarkable for the shift from primary monotherapy towards fixed dose combinations as the study concluded. The decline in the number of beta blocker prescriptions and a rise in prostaglandin analog prescriptions is a testament to their better effectiveness and tolerability. The future of open angle glaucoma pharmacotherapy lies in prescribing more efficacious drugs either in monotherapy or in fixed combinations.

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TO STUDY THE DRUG USE PATTERN IN PRIMARY OPEN ANGLE GLAUCOMA IN A TERTIARY CARE TEACHING

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2017.v10i2.15172 ◽

2017 ◽

Vol 10 (2) ◽

pp. 198

Author(s):

Deepalatha C ◽

Leela Pratyusha Mb

Keyword(s):

Drug Use ◽

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

Tertiary Care ◽

Fixed Dose Combination ◽

Fixed Dose ◽

Open Angle ◽

Duration Of Treatment ◽

Care Teaching ◽

Dose Combination

Objective: To study the drug utilization pattern in patients suffering from primary open-angle glaucoma (POAG) in a tertiary care teaching hospital.Methods: It is a prospective study done on 50 patients of POAG (comprising of individuals belonging to any age group). This study was carried for a period of 2-month, and the data included patient’s demographic details and the drugs prescribed. Data were analyzed for drug use pattern.Results: After screening the prescriptions of patients, it was found out that out of total 50 prescriptions, 30 were males, and 20 were females. Out of50 prescriptions, prostaglandins (58%) were most commonly prescribed. β-blockers (16%) were also prescribed. Fixed dose combination constituted60% of the prescriptions. Instructions about the route, frequency, and duration of treatment were present in all prescriptions. Drugs prescribed by their generic names were 18.75% and about 81.25% of the drugs were prescribed by their brand names.Conclusions: Fixed drug combination of timolol and dorzolamide was the most frequently prescribed combination. Prescribers must be aware ofimportance of prescribing drugs with generic names.Keywords: Primary open-angle glaucoma, Intraocular pressure, Fixed dose combination.

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PSS4 A Cost Effectiveness Analysis of Latanoprost Monotherapy, Netarsudil Monotherapy and Fixed Dose Combination Latanoprost/Netarsudil in Management of Primary Open Angle Glaucoma in USA

Value in Health ◽

10.1016/j.jval.2021.04.1105 ◽

2021 ◽

Vol 24 ◽

pp. S220-S221

Author(s):

K. Adjei ◽

A.A. Ali

Keyword(s):

Cost Effectiveness ◽

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

Cost Effectiveness Analysis ◽

Fixed Dose Combination ◽

Fixed Dose ◽

Open Angle ◽

Effectiveness Analysis ◽

Dose Combination

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The role of fixed dose combinations in the treatment of primary open-angle glaucoma

Vestnik oftal mologii ◽

10.17116/oftalma2018134041100 ◽

2018 ◽

Vol 134 (4) ◽

pp. 100

Author(s):

S. Yu. Petrov ◽

V. S. Zinina ◽

A. V. Volzhanin

Keyword(s):

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

Fixed Dose ◽

Open Angle

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Treatment of Primary Open-Angle Glaucoma and Ocular Hypertension with Preservative-Free Tafluprost-Timolol Fixed-Dose Combination Versus Preservative-Free Latanoprost-Timolol Fixed-Dose Combination Therapy: Real-World Experience

10.21203/rs.3.rs-1100928/v1 ◽

2021 ◽

Author(s):

Ulrich Thelen

Keyword(s):

Combination Therapy ◽

Ocular Hypertension ◽

Primary Open Angle Glaucoma ◽

Fixed Combination ◽

Open Angle Glaucoma ◽

Fixed Dose Combination ◽

Fixed Dose ◽

Open Angle ◽

Dose Combination ◽

Preservative Free

Abstract Background: To evaluate the effect of an "escalation" of topical glaucoma therapy by switching form prostaglandin monotherapy to two different prostaglandin-timolol fixed combinations.Methods: 30 patients (60 eyes) with primary open-angle glaucoma (POAG) or ocular hypertension (OHT) were initially treated with the prostaglandin analog latanoprost in a preservative-free formulation. 15 patients each were for 6 months - because of IOP levels considered still too high - treated with preservative-free tafluprost/timolol fixed-dose combination or preservative-free latanoprost/timolol fixed-dose combination therapy. Results: Six months after switching from latanopost monotherapy to preservative-free prostaglandin-timolol combinations, patients being treated with the latanoprost-timolol fixed combination had a mean IOP reduction by 4.16 mm Hg and those treated with the tafluprost-timolol fixed combination a mean IOP reduction by 5.38 mm Hg. Regarding safety and tolerability, there were no issues in the tafluprost-timolol group.Conclusions: Switching from prostaglandin monotherapy to a prostaglandin-timolol fixed combination led to a sufficient IOP lowering in our group of patients. Tolerability of, and satisfaction with, the fixed combination therapies was high.

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A drug utilization study in glaucoma patients in ophthalmology out patient department in a tertiary care hospital

International Journal of Basic & Clinical Pharmacology ◽

10.18203/2319-2003.ijbcp20173277 ◽

2017 ◽

Vol 6 (8) ◽

pp. 1955

Author(s):

Kaushal B. Patel ◽

Gurusharan H. Dumra ◽

Adarsh Jeet Singh ◽

Abhishek Vyas ◽

Chetan G. Parmar

Keyword(s):

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

Common Variant ◽

Fixed Dose Combination ◽

World Health ◽

Fixed Dose ◽

Care Hospital ◽

Open Angle ◽

Dose Combination ◽

Patient Department

Background: According to World Health Organization (WHO) studies Glaucoma is a chronic progressive symptomatic disease that damages retinal cells and is one of the leading cause of preventable blindness worldwide. Availability of newer topical agents has modernized the management of glaucoma.Methods: A prospective observational study was carried out from August 2016 to December 2016 at ophthalmology Out Patient Department of L.G General Hospital, Ahmedabad by authours after the approval of the Institutional Ethics Committee.Results: Out of total 101 patients, 71 were males and 30 were females. Average age of patient is 54 years. Common variant of Glaucoma was Primary Open Angle Glaucoma in 57.4% of patients. Average number of drugs per prescription was 2 (45%). Most commonly used Fixed Dose Combination was Brimonidine +Timolol Drops which was used in 87 (86.1%) patients. Most commonly used adjuvant drug was Tab. Acetazolamide (60% of patients).Conclusions: Common variant of Glaucoma was Primary Open Angle Glaucoma in 57.4% of patients. Most commonly used Fixed Dose Combination was Brimonidine+Timolol Drops which was used in 87 (86.1%) patients and commonly used Single drug therapy is Tab. Acetazolamide in (60% of patients).

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OCT angiography in a comprehensive assessment of hypotensive therapy effectiveness in patients with primary open-angle glaucoma

Russian Ophthalmological Journal ◽

10.21516/2072-0076-2019-12-3-43-49 ◽

2019 ◽

Vol 12 (3) ◽

pp. 43-49

Author(s):

T. N. Yurieva ◽

S. I. Zhukova

Keyword(s):

Blood Flow ◽

Antihypertensive Therapy ◽

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

Capillary Density ◽

Ocular Blood Flow ◽

Open Angle ◽

Therapy Effectiveness ◽

Hypotensive Therapy ◽

Flow Changes

Degenerative changes in the retina of primary open-angle glaucoma (POAG) patients are developing as response to ischemia and chronic hypoxia accompanied by intolerant IOP. For this reason, the analysis of ocular blood flow changes in glaucoma monitoring, as well as the basic tests, should be considered an integral part of comprehensive examination of such patients.The purpose is to identify the most informative markers of the disease and to assess the effectiveness of its antihypertensive therapy by the fixed combination Dorzolamide / Timolol (Dorzopt Plus). Material and methods. 34 patients aged 68.44 ± 4.26 years with an advanced POAG stage and sub- or decompensated IOP were examined. The examination included optical coherence tomography in the angiography mode.Results. A stable average reduction in IOP by 35.1 % (by 8.6 ± 0.7 mm Hg, p < 0.05) as compared with the baseline was achieved. IOP normalization was accompanied by a stable increase in corneal hysteresis and perfusion pressure, a decrease in the average depth of the perimetric defect, and changes in chorioretinal blood flow.Conclusion. Changes in the choroid thickness and capillary density of the retinal peripapillary layer may be considered as the most informative biomarkers in the diagnosis of glaucoma and the evaluation of antihypertensive therapy effectiveness.

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