scholarly journals Pharmacological approaches to the treatment of combined functional pathology (biliary and intestinal tract)

2018 ◽  
pp. 78-82
Author(s):  
O. N. Minushkin
Keyword(s):  
Irritable Bowel Syndrome ◽  
Abdominal Pain ◽  
Intestinal Tract ◽  
Overlap Syndrome ◽  
Functional Disorder ◽  
Functional Disorders ◽  
New Classification ◽  
Irritable Bowel ◽  
Rome Iv

The article presents data on a new classification of functional disorders according to Rome IV criteria. Particular attention is given to the combined functional pathology - the overlap syndrome. The combination of functional biliary disorders (PBD) and irritable bowel syndrome (IBS) is the most common functional disorder. The tactic of conservative treatment - the choice of myotropic antispasmodic is considered. The analysis of the results of our own study of the efficacy of Niaspam in the treatment of abdominal pain, flatulence and stool disorders in patients with PBD and IBS are presented.

scholarly journals “Gastrointestinal” comorbidity in irritable bowel syndrome

2021 ◽  
Vol 1 (6) ◽  
pp. 104-111
Author(s):  
O. V. Gaus ◽  
M. A. Livzan
Keyword(s):  
Irritable Bowel Syndrome ◽  
Clinical Practice ◽  
Characteristic Feature ◽  
Overlap Syndrome ◽  
Diagnosis And Treatment ◽  
Urgent Problem ◽  
Functional Disorders ◽  
Modern Information ◽  
Irritable Bowel ◽  
Real Clinical Practice

Among the large and heterogeneous group of patients with irritable bowel syndrome (IBS) comorbidity is characteristic feature. Comorbidity is an urgent problem in real clinical practice. Gastrointestinal comorbidity of a patient with IBS is associated with the presence of common pathogenetic links and is represented by combined pathology with functional disorders and the formation of “overlap syndrome” with organic diseases. Often, with a comorbid course, the phenomenon of “mutual burdening” is observed, when the severity of the course of each of them increases. All this requires optimization of approaches to the diagnosis and treatment of this cohort of patients. Obviously, with a comorbid course of IBS, it is advisable to prescribe drugs that affect the general links of pathogenesis, rather than focusing on individual symptoms. This article presents modern information on the gastrointestinal comorbidity of a patient with IBS.

scholarly journals Irritable bowel syndrome and biliary tract pathology. Clinical analysis

2020 ◽  
pp. 28-38
Author(s):  
T. E. Polunina
Keyword(s):  
Irritable Bowel Syndrome ◽  
Abdominal Pain ◽  
Gastrointestinal Tract ◽  
Biliary Tract ◽  
Emotional Health ◽  
Biological Marker ◽  
Recurrent Abdominal Pain ◽  
Clinical Analysis ◽  
Functional Disorders ◽  
Irritable Bowel

Irritable bowel syndrome (IBS) – a recurrent functional disorder of the gastrointestinal tract (GIT), the main symptom of which is abdominal pain necessarily associated with a change in intestinal function. IBS is a functional intestinal disorder in which recurrent abdominal pain is associated with a defecation act and a change in the frequency or shape of the stool. The diagnosis of IBS remains exclusively clinical. The difficulty in studying IBS, especially from the perspective of its epidemiology, is that there is still no universal and specific biological marker. Very often patients complain about symptoms typical for several functional disorders, in particular, biliary tract pathology and IBS. The article discusses the multi-component causes and mechanisms of IBS formation, which are also present in other functional gastrointestinal tract diseases. Patients with IBS often have functional disorders of the biliary tract (FDBT) that are not associated with organic pathology. There are no reliable differences in the frequency and nature of FDBT in patients with IBS, depending on its current variant - with constipation or diarrhea prevalence. As a result, the treatment of patients with IBS remains a challenge, and the recurrence of the disease depends on the state of psycho-emotional health, the presence of overlap syndrome in most cases. The article presents the main international criteria for diagnostics of IBS. The main approaches to the treatment of IBS are considered. Good results in the treatment of IBS are observed when using drugs that affect the complex of pathophysiological mechanisms of the disease. This is confirmed in the article by a clinical case study. The prescription of the Sparex drug for pain relief in a patient with IBS and FDBT is justified by the fact that it not only eliminates pain, but also improves the rheological properties of bile, typical for overlap “IBS-FDBT” syndrome.

scholarly journals Functional constipation masked as irritable bowel syndrome

2020 ◽  
Author(s):  
Monica Tosto ◽  
Paola D’Andrea ◽  
Ignazio Salamone ◽  
Salvatore Pellegrino ◽  
Stefano Costa ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Abdominal Pain ◽  
Functional Gastrointestinal Disorders ◽  
Functional Constipation ◽  
Control Group ◽  
Number Of Patients ◽  
Erroneous Diagnosis ◽  
Irritable Bowel ◽  
Mixed Pattern ◽  
Rome Iv

Abstract Background: Rome IV criteria for functional gastrointestinal disorders state that children suspected of having Irritable Bowel Syndrome (IBS) with Constipation (IBS-C) should be preliminarily treated for constipation. We aimed at verifying if functional constipation may indeed lead to an erroneous diagnosis of IBS with diarrhea (IBS-D) or IBS with mixed pattern of diarrhea and constipation (IBS-M). Methods: We prospectively enrolled in an unblinded fashion 10 and 16 consecutive children referred to our center who met Rome IV criteria for a diagnosis of IBS-D and IBS-M, respectively. Patients who fulfilled criteria for suspect “occult constipation” were then given a bowel cleaning regimen with Polyethylene glycol 3350, re-evaluated at 2 months and followed up for at least 6 months. Sixteen additional patients with IBS with Constipation (IBS-C) referred in the same period served as control. The endpoints were: 1) a decrease of more than 50% in abdominal pain intensity and frequency scores; and 2) for patients with IBS-D and IBS-M: resolution of diarrhea. Results: The endpoints were met by 8 (80%) and 14 (87%) of the patients with IBS-D and IBS-M, respectively, with decrease of abdominal pain and resolution of “diarrhea”. The response was not significantly different from that observed in 15 (93%) of the IBS-C control group. Conclusion: Acknowledging the limitations of the small number of patients and of the uncontrolled nature of the study, we suggest that a possibly large number of patients labeled as IBS-D or IBS-M may actually simply present functional constipation and should be managed as such.

scholarly journals Prospects for the use of biomarkers in the diagnosis of irritable bowel syndrome

2020 ◽  
pp. 94-101
Author(s):  
V. A. Akhmedov ◽  
A. K. Sargsyan ◽  
O. V. Gaus
Keyword(s):  
Irritable Bowel Syndrome ◽  
Abdominal Pain ◽  
Recurrent Abdominal Pain ◽  
Diagnosis And Treatment ◽  
Functional Disorder ◽  
Wide Range ◽  
Irritable Bowel ◽  
Number Of Publications

Irritable bowel syndrome is a chronic functional disorder of the intestine, manifested by altered intestinal habits and recurrent abdominal pain in combination with two or more criteria: association with defecation, association with a change in the frequency of defecation, association with a change in the appearance of the stool. To date, IBS remains a diagnosis of exclusion that needs to be differentiated from a wide range of organic diseases. In recent years, a large number of publications have appeared on the research of etiopathogenesis, diagnosis and treatment of IBS. This literary review highlights the problems of searching for biomarkers of IBS as a way to solve the problem of diagnosis of this pathology and understanding the causes of its occurrence.

scholarly journals Functional constipation masked as irritable bowel syndrome

2020 ◽  
Author(s):  
Monica Tosto ◽  
Paola D’Andrea ◽  
Ignazio Salamone ◽  
Salvatore Pellegrino ◽  
Stefano Costa ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Abdominal Pain ◽  
Functional Gastrointestinal Disorders ◽  
Functional Constipation ◽  
Gastrointestinal Disorders ◽  
Number Of Patients ◽  
Erroneous Diagnosis ◽  
Irritable Bowel ◽  
Mixed Pattern ◽  
Rome Iv

Abstract Background Rome IV criteria for functional gastrointestinal disorders state that children suspected of having Irritable Bowel Syndrome (IBS) with Constipation (IBS-C) should be preliminarily treated for constipation. We aimed at verifying if functional constipation may indeed lead to an erroneous diagnosis of IBS with diarrhea (IBS-D) or IBS with mixed pattern of diarrhea and constipation (IBS-M).Methods We prospectively enrolled in an unblinded fashion 10 and 16 consecutive children referred to our center who met Rome IV criteria for a diagnosis of IBS-D and IBS-M, respectively. Patients who fulfilled criteria for suspect “occult constipation” were then given a bowel cleaning regimen with PEG 3350, re-evaluated at 2 months and followed up for at least 6 months. Sixteen additional patients with IBS with Constipation (IBS-C) referred in the same period served as control. The endpoints were: 1) a decrease of more than 50% in abdominal pain intensity and frequency scores; and 2) for patients with IBS-D and IBS-M: resolution of diarrhea.Results The endpoints were met by 8 (80%) and 14 (87%) of the patients with IBS-D and IBS-M, respectively, with decrease of abdominal pain and resolution of “diarrhea”. The response was not significantly different from that observed in 15 (93%) of the IBS-C control group.Conclusion acknowledging the limitations of the small number of patients and of the uncontrolled nature of the study, we suggest that a possibly large number of patients labeled as IBS-D or IBS-M may actually simply present functional constipation and should be managed as such.

scholarly journals Post-infectious Irritable Bowel Syndrome: A Narrative Review

2019 ◽  
Vol 11 (2) ◽  
pp. 69-75 ◽  
Author(s):  
Anahita Sadeghi ◽  
Mohammad Biglari ◽  
Siavosh Nasseri Moghaddam
Keyword(s):  
Irritable Bowel Syndrome ◽  
Diagnostic Criteria ◽  
Host Response ◽  
Specific Treatment ◽  
Infectious Agent ◽  
Functional Disorder ◽  
Infectious Gastroenteritis ◽  
Irritable Bowel ◽  
Post Infectious ◽  
Rome Iv

The Irritable bowel syndrome (IBS) is a functional disorder of alimentary system, which may be caused by infectious gastroenteritis determined as post infectious irritable bowel syndrome (PI-IBS). The prevalence of PI-IBS is reported to be 4-36% in patients with infectious gastroenteritis. The exact mechanism leading to PI-IBS is not fully understood and some factors pertaining to infectious agent and host response may have a role. Rome IV diagnostic criteria provided new definition for PI-IBS. Though it is now considered a well-defined functional disorder of gastrointestinal system, no specific treatment is yet available for PI-IBS. This article reviews the latest issues on these heading about PI-IBS.

scholarly journals Assessment Of Clinical And Psychological Status And Quality Of Life Of Patients In Different Forms Of Irritable Bowel Syndrome

2021 ◽  
Vol 03 (02) ◽  
pp. 127-134
Author(s):  
Abdullayev R.B. ◽  
◽  
Makhmudova L.I. ◽  
Keyword(s):  
Quality Of Life ◽  
Irritable Bowel Syndrome ◽  
Abdominal Pain ◽  
Pain Syndrome ◽  
Psychological Status ◽  
Moderate Intensity ◽  
Functional Disorders ◽  
Irritable Bowel ◽  
Leading Symptom

Irritable bowel syndrome (IBS) is a biopsychosocial disorder that consists of a set of functional disorders that cannot be explained by organic changes in the intestines. At present, it is very important to determine the indicators of quality of life (QOL) in patients with various diseases. QOL analysis allows us to determine how well a patient is coping with the disease, and is also important for addressing many of the issues that arise during treatment. The main complaints of patients were fecal incontinence (100%) and pain syndrome (100%). In patients with IBS with predominance of diarrhea and constipation, the leading symptom in the clinical picture of the disease is pain throughout the bowel, which decreases or disappears after defecation, accompanied by flatulence and a feeling of complete bowel emptying. ± 0.25 points (according to the results of the GSRS survey), which corresponds to severe and moderate intensity pain syndrome. At the end of the course of treatment, a statistically significant decrease in the intensity of abdominal pain was observed in patients.

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