scholarly journals Protective Effect of Captopril and Nigella Sativa Oil against Carbon Tetrachloride Induced Nephrotoxicity in Male Rats

2015 ◽  
Vol 24 (1) ◽  
pp. 129-144
Author(s):  
Khaled Abdel Aal ◽  
Nashwa Mostafa
Keyword(s):  
Carbon Tetrachloride ◽  
Protective Effect ◽  
Nigella Sativa ◽  
Male Rats ◽  
Nigella Sativa Oil

Protective effect of vanillin against carbon tetrachloride (CCl4)-induced oxidative brain injury in rats

2011 ◽  
Vol 28 (7) ◽  
pp. 655-662 ◽  
Author(s):  
Mohamed Makni ◽  
Yassine Chtourou ◽  
Mohamed Barkallah ◽  
Hamadi Fetoui
Keyword(s):  
Carbon Tetrachloride ◽  
Protective Effect ◽  
Brain Damage ◽  
Glutathione Transferase ◽  
Single Injection ◽  
Male Rats ◽  
Control Group ◽  
Protective Effects ◽  
Degree Of Protection ◽  
Oxidative Brain Injury

This study investigated the protective effects of vanillin against acute brain damage induced by carbon tetrachloride (CCl4) in rats. The study was performed on 32 male rats divided into four groups: a control group, vanillin group ([Va] 150 mg/kg/day, intraperitoneally [i.p.]) and CCl4 toxication groups received a single injection of CCl4 (1 ml/kg, i.p.; CCl4 and Va + CCl4 groups). The degree of protection in brain tissue was evaluated by the levels of malondialdehyde (MDA), glutathione (GSH), superoxide dismutase, glutathione transferase, glutathione peroxidase and nitric oxide (NO). Vanillin showed a significant brain-protective effect by decreasing the level of lipid peroxidation and NO2 and elevated the activities of antioxidative enzymes and level of GSH. Consequently vanillin blocked oxidative brain damage induced by CCl4 in rats.

Protective Effect of Nigella sativa Seeds Against Lead-induced Hepatorenal Damage in Male Rats

2007 ◽  
Vol 10 (17) ◽  
pp. 2809-2816 ◽  
Author(s):  
Abdel-Razik H. Farrag ◽  
Karam A. Mahdy ◽  
Gamal H. Abdel Rahman ◽  
Mostafa M. Osfor
Keyword(s):  
Protective Effect ◽  
Nigella Sativa ◽  
Male Rats

Protective effect of Nigella sativa oil on cisplatin induced nephrotoxicity and oxidative damage in rat kidney

2017 ◽  
Vol 85 ◽  
pp. 7-15 ◽  
Author(s):  
Zeba Farooqui ◽  
Faizan Ahmed ◽  
Sana Rizwan ◽  
Faaiza Shahid ◽  
Aijaz Ahmed Khan ◽  
...  
Keyword(s):  
Oxidative Damage ◽  
Protective Effect ◽  
Nigella Sativa ◽  
Rat Kidney ◽  
Nigella Sativa Oil

scholarly journals Protective role of Nigella sativa oil on renal damage induced by acetaminophen in male rats

2017 ◽  
Vol 40 (2) ◽  
pp. 77-81
Author(s):  
Zena M. Hamad
Keyword(s):  
Serum Creatinine ◽  
Blood Urea Nitrogen ◽  
Nigella Sativa ◽  
Nitrogen Concentration ◽  
Antioxidant Properties ◽  
Male Rats ◽  
Control Group ◽  
Urea Nitrogen ◽  
Nigella Sativa Oil ◽  
Nitrogen Concentrations

     Acetaminophen also called paracetamol is commonly used as analgesic and antipyretic agent which in high doses causes liver and kidney damage in man and animals. Nigella sativa oil have antioxidant properties. Thirty adult male rats were used and randomly divided into three equal groups. Group (A) untreated and served as control group; Group (B) rats were orally intubated (by gavages needle) acetaminophen suspension (150mg/kg B.W). Group (C) rats were given orally acetaminophen suspension (150mg/kg) plus 1ml/kg B.W of Nigella sativa oil for 42 days in both treated group. Fasting blood samples were collected at 21 and 42 days of experiment to study the following parameters:  Serum creatinine concentration and blood urea nitrogen concentration. The results revealed a significant increase of acetaminophen group in serum creatinine and blood urea nitrogen concentrations as compression with GA. Animals treated with Nigella sativa oil plus acetaminophen (C) showed a significant decline in serum creatinine and blood urea nitrogen concentrations. In conclusion, the acetaminophen was effective in induction of oxidative stress and change in some biological markers related to kidney disease. Also it seems that Nigella sativa oil exerts protective actions against the damaging effect of acetaminophen

scholarly journals Protective effect of Nigella sativa oil against thioacetamide-induced liver injury in rats

2017 ◽  
pp. 1
Author(s):  
Kevser Tanbek ◽  
Elif Ozerol ◽  
Sedat Bilgic ◽  
Mustafa Iraz ◽  
Nurhan Sahin ◽  
...  
Keyword(s):  
Liver Injury ◽  
Protective Effect ◽  
Nigella Sativa ◽  
Nigella Sativa Oil
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