scholarly journals Role of Repetitive Nerve Stimulation, Serum Creatine Phosphokinase and Lactate Dehydrogenase in Early Prediction of Respiratory Failure in Acute Organophosphorus Poisoning

2015 ◽  
Vol 24 (1) ◽  
pp. 180-195
Author(s):  
Samah Elnagdy ◽  
Nahed Shehta
Keyword(s):  
Respiratory Failure ◽  
Lactate Dehydrogenase ◽  
Nerve Stimulation ◽  
Creatine Phosphokinase ◽  
Early Prediction ◽  
Repetitive Nerve Stimulation ◽  
Serum Creatine Phosphokinase ◽  
Organophosphorus Poisoning ◽  
Acute Organophosphorus Poisoning

scholarly journals Evaluation of Serum Creatine Phosphokinase as a Marker of Severity in Organophosphorus Poisoning

2018 ◽  
Vol 9 (5) ◽  
pp. 179
Author(s):  
Yogendra V. Bansod ◽  
Swapnil G. Bhedodkar
Keyword(s):  
Creatine Phosphokinase ◽  
Prognostic Significance ◽  
Clinical Severity ◽  
Serum Cholinesterase ◽  
Serum Creatine Phosphokinase ◽  
Organophosphorus Poisoning ◽  
Severe Clinical Picture ◽  
Scale Category ◽  
Global Health Problem

Background & Objectives: Organophosphorus (OP) poisoning is an important global health problem. Estimation of erythrocyte cholinesterase (EChE) and butyrylcholinesterase (BChE) as an evidence of OP poisoning is costly and not regularly performed. There are emerging options for new cheaper biochemical markers in relation to OP poisoning like creatine phosphokinase (CPK). The objectives of this study were to measure serum CPK level and correlate it with severity of poisoning, to evaluate clinical and prognostic significance of CPK in OP poisoning, to assess if serum CPK level can be used as an alternative of BChE level to stratify OP poisoning severity.Method: Total 100 patients of OP poisoning without any prior treatment, presenting within 12 hours, were selected and their clinical severity was categorized according to Peradeniya Organophosphorus Poisoning (POP) scale. Level of serum CPK, blood BChE and pH were measured and total dose of atropine required (mg) until final clinical outcome was calculated.Results: Out of 100, 43% patients had mild, 36% moderate and 21% severe clinical picture. There was a significant positive correlation between serum CPK value and requirement of atropine dose in patient with severe POP scale category and negative correlation with pH and serum cholinesterase levels, indicating that more severe the poisoning more will be serum CPK and requirement of atropine doses while less will be pH and serum cholinesterase, (p<0.0001).Conclusions: This study suggests role of serum creatine kinase as surrogate, relatively cheap and easily quantifiable markers of severe OPC exposure and their association.

scholarly journals Study of serum creatinine phosphokinase and serum lactate dehydrgenase as prognostic markers in organophosphorus poisoning

2020 ◽  
Vol 7 (7) ◽  
pp. 1125
Author(s):  
Raghu G. ◽  
Ayyanagouda A. Gangannavar ◽  
Manoj Kumar B. K. ◽  
Umesh Rajoor
Keyword(s):  
Respiratory Failure ◽  
Biochemical Parameters ◽  
Prognostic Markers ◽  
Serum Lactate ◽  
Age Group ◽  
Mean Values ◽  
Detailed History ◽  
Organophosphorus Poisoning ◽  
Male Patients ◽  
Acute Organophosphorus Poisoning

Background: Organophosphorus (OP) compounds are insecticides which are widely used in agriculture. Acute organophosphorus poisoning is an important cause of morbidity and mortality in developing countries like India. In a limited resourced country like India, we need cheap and easily measurable biomarkers for predicting prognosis.Objective was to estimate creatinine phosphokinase and serum lactate dehydrgenase as prognostic markers in acute organophosphorus poisoning.Methods: Total 94 cases of OP poisoning admitted to KIMS Hospital, Hubbali between January 1st 2017 to December 31th 2017 were studied. Detailed history, clinical examination and lab investigations like pseudo cholinesterase, serum LDH and serum CPK were carried out. Peradeniya OP poisoning scale was applied to all study subjects and the severity of OP poisoning was graded as mild, moderate, severe. Data obtained was analysed by different statistical methods.Results: OP poisoning is more common in adults of age group between 20 - 30 years, Incidence is was more in male patients, Mortality rate is 12.8%. Mean values of serum LDH, serum CPK were negatively correlated with pseudcholinesterase levels and it was statistically significant. Correlation between the severity of OP poisoning (based on Peradenyia score) and biochemical parameters like serum CPK, serum LDH, was statistically significant.Conclusions: The correlation between the severity of OP poisoning and biochemical parameters was statistically significant and they are usefull in predicting development of respiratory failure.

scholarly journals ROLE OF SERUM CHOLINESTERASE IN ACUTE ORGANOPHOSPHORUS POISONING: A HOSPITAL BASED CROSS SECTIONAL STUDY

2015 ◽  
Vol 4 (30) ◽  
pp. 5102-5108
Author(s):  
Giridhar Patil ◽  
Nimbal N V ◽  
Arun V. Joshi ◽  
Archana Dambal ◽  
Madhavaranga M P ◽  
...  
Keyword(s):  
Cross Sectional Study ◽  
Serum Cholinesterase ◽  
Sectional Study ◽  
Cross Sectional ◽  
Organophosphorus Poisoning ◽  
Acute Organophosphorus Poisoning

scholarly journals Study of Serum Amylase for Predicting the Severity of Organophosphorus Poisoning and Correlation with Respiratory Failure - A Cross Sectional Study at KIMS, Hubballi, Karnataka

2021 ◽  
Vol 8 (20) ◽  
pp. 1473-1478
Author(s):  
Raghu Gangadharappa ◽  
Manojkumar B. Kalegowda ◽  
Bharath Golla
Keyword(s):  
Respiratory Failure ◽  
Serum Amylase ◽  
Financial Burden ◽  
Limited Resource ◽  
Biochemical Parameter ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Mean Values ◽  
Organophosphorus Poisoning ◽  
Acute Organophosphorus Poisoning

BACKGROUND Organophosphorus (OP) compounds are insecticides which are widely used in agriculture. Acute organophosphorus poisoning is one of the important causes of morbidity and mortality in developing countries like India. Considering financial burden / availability of tests, we need cheap and easily measurable biomarkers for predicting prognosis / complications in a limited resource country, like India. We intend to correlate the levels of serum amylase in patients admitted with acute organophosphorus poisoning for predicting the severity of acute OP poisoning and also to correlate serum amylase association with respiratory failure. METHODS This was a prospective observational study. Total of 94 patients of OP poisoning admitted to KIMS Hospital, Hubballi between January 1st 2017 and December 31th 2017 were studied. Detailed history, clinical examination, and lab investigations like pseudocholinesterase, serum amylase and other relevant investigations were carried out. Peradeniya OP poisoning scale was applied to all the study subjects and the severity of OP poisoning was graded as mild, moderate, severe. Data obtained was analysed by different statistical methods. RESULTS OP poisoning was more common in adults of age group between 20 – 30 years, Incidence was more in male patients and mortality rate was 12.8 %. Mean values of serum amylase negatively correlate with pseudocholinesterase levels and it was statistically significant. Correlation between the severity of OP poisoning (based on Peradeniya score) and biochemical parameters like pseudocholinesterase, serum amylase was statistically significant. CONCLUSIONS The correlation between the severity of OP poisoning and biochemical parameter– serum amylase, was statistically significant and it was useful in predicting the development of respiratory failure. Pseudocholinesterase and serum amylase were also useful to predict the outcome of the patient. KEYWORDS Amylase, Organophosphorus Poisoning, Pseudocholinesterase, Peradeniya Score

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