scholarly journals DETECTION OF GASTROINTESTINAL LESIONS CAUSING IRON DEFICIENCY ANEMIA USINGGASTROINTESTINAL ENDOSCOPY

2022 ◽  
Vol 51 (1) ◽  
pp. 485-494
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Deficiency Anemia ◽  
Gastrointestinal Lesions

scholarly journals Molecular Aspects and Treatment of Iron Deficiency in the Elderly

2020 ◽  
Vol 21 (11) ◽  
pp. 3821
Author(s):  
Antonino Davide Romano ◽  
Annalisa Paglia ◽  
Francesco Bellanti ◽  
Rosanna Villani ◽  
Moris Sangineto ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Iron Homeostasis ◽  
Diagnostic Algorithm ◽  
The Elderly ◽  
Deficiency Anemia ◽  
Clinical State ◽  
Ageing Population ◽  
Gastrointestinal Lesions ◽  
Aged Subjects

Iron deficiency (ID) is the most frequent nutritional deficiency in the whole population worldwide, and the second most common cause of anemia in the elderly. The prevalence of anemia is expecting to rise shortly, because of an ageing population. Even though WHO criteria define anemia as a hemoglobin serum concentration <12 g/dL in women and <13 g/dL in men, several authors propose different and specific cut-off values for the elderly. Anemia in aged subjects impacts health and quality of life, and it is associated with several negative outcomes, such as longer time of hospitalization and a higher risk of disability. Furthermore, it is an independent risk factor of increased morbidity and mortality. Even though iron deficiency anemia is a common disorder in older adults, it should be not considered as a normal ageing consequence, but a sign of underlying dysfunction. Relating to the molecular mechanism in Iron Deficiency Anemia (IDA), hepcidin has a key role in iron homeostasis. It downregulates the iron exporter ferroportin, inhibiting both iron absorption and release. IDA is frequently dependent on blood loss, especially caused by gastrointestinal lesions. Thus, a diagnostic algorithm for IDA should include invasive investigation such as endoscopic procedures. The treatment choice is influenced by the severity of anemia, underlying conditions, comorbidities, and the clinical state of the patient. Correction of anemia and iron supplementation should be associated with the treatment of the causal disease.

scholarly journals Gastrointestinal Lesions in African American Patients With Iron Deficiency Anemia

2018 ◽  
Vol 11 ◽  
pp. 117955221877862 ◽  
Author(s):  
Hassan Brim ◽  
Anahita Shahnazi ◽  
Mehdi Nouraie ◽  
Dilhana Badurdeen ◽  
Adeyinka O Laiyemo ◽  
...  
Keyword(s):  
African American ◽  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Clinical Laboratory ◽  
Demographic Data ◽  
Deficiency Anemia ◽  
Gi Bleeding ◽  
Associated Lesions ◽  
Asymptomatic Patients ◽  
Gastrointestinal Lesions

Background: Iron deficiency anemia (IDA) is a frequent disorder that is associated with many serious diseases. However, the findings of an evaluation of IDA-associated gastrointestinal disorders are lacking among African American patients. Aim: To determine the most prevalent gastrointestinal lesions among African American patients with IDA especially in young men. Methods: We reviewed medical records (n = 422) of patients referred for evaluation of IDA from 2008 to 2012. Iron deficiency anemia was diagnosed using clinical laboratory tests. The results of esophagogastroduodenoscopy, colonoscopy, and pathology specimens along with demographic data were abstracted and analyzed using Stata. Results: The mean age was 61.9 years, and 50.5% were women. In total, 189 patients (45%) had gross gastrointestinal (GI) bleeding. The most frequent diagnoses were gastritis (40%), benign colonic lesions (13%), esophagitis (9%), gastric ulcer (6%), and duodenitis (6%). GI bleeding was significantly more frequent in men ( P = 0.001). Benign and malignant colonic lesions were significantly more present among older patients: 16% vs 6% ( P = .005) and 5% vs 0% ( P = .008), respectively. Colitis was more prevalent in younger patients (⩽50): 11% vs 2% ( P = .001). In patients with gross lower GI bleeding, the top diagnoses were gastritis (25%), benign colon tumors (10%), and duodenitis (6%). Colon cancer was diagnosed among 15 patients, and all these patients were older than 50 years of age. Conclusions: Gastritis and colonic lesions are most common associated lesions with IDA among African Americans. So bidirectional endoscopy is required for unrevealing of the cause of IDA in asymptomatic patients.

scholarly journals Identification of clinical and simple laboratory variables predicting responsible gastrointestinal lesions in patients with iron deficiency anemia

2011 ◽  
Vol 8 (1) ◽  
pp. 30-38 ◽  
Author(s):  
Songul Serefhanoglu ◽  
Yahya Buyukasik ◽  
Hakan Emmungil ◽  
Nilgun Sayinalp ◽  
Ibrahim Celalettin Haznedaroglu ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Deficiency Anemia ◽  
Gastrointestinal Lesions ◽  
Laboratory Variables

Mo1070 Gastrointestinal Lesions in African American Patients With Iron Deficiency Anemia

2015 ◽  
Vol 148 (4) ◽  
pp. S-596
Author(s):  
Anahita Shahnazi ◽  
Hassan Brim ◽  
Tahmineh Haidary ◽  
Mya T. Myint ◽  
Shiva Salehian ◽  
...  
Keyword(s):  
African American ◽  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Deficiency Anemia ◽  
Gastrointestinal Lesions

scholarly journals Iron deficiency anemia and its importance in gastroenterology clinical practice

2007 ◽  
Vol 54 (1) ◽  
pp. 91-105 ◽  
Author(s):  
D. Vucelic ◽  
B. Nenadic ◽  
P. Pesko ◽  
M. Bjelovic ◽  
D. Stojakov ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Intellectual Development ◽  
Reproductive Period ◽  
Deficiency Anemia ◽  
Comprehensive Understanding ◽  
Endoscopic Evaluation ◽  
Children And Adolescent ◽  
Iron Losses ◽  
Gastrointestinal Lesions

Iron deficiency anemia (IDA) is a universal problem involving individuals of all ages and both sexes and is a common cause of referral to medical departments. This anemia is one of the most common types of anemia. IDA impairs growth and intellectual development in children and adolescent. In women IDA is most common in reproductive period because of menstrual and pregnancy iron losses. IDA affects roughly 10-30% of all pregnancies and, among others morbidities, may contribute of developing postpartum depression. Among other adult patient, chronic occult gastrointestinal bleeding is the leading cause of IDA. Approximately, one third of patients with anemia have iron deficiency and up to two thirds of patients with IDA have serious gastrointestinal lesions detected with esophagogastroduodenoscopy and colonoscopy, including 10-15% with malignancy. However, in practice not all anemic patients undergo appropriate diagnostic tests to detect iron deficiency. Furthermore, a substantial proportion of patients with IDA do not undergo endoscopic evaluation. The approach to its investigation and subsequent therapy depends upon a comprehensive understanding of iron metabolism and heme synthesis. Once diagnosis of iron deficiency or IDA is established, evaluation for the cause of anemia must be appropriate performed and treatment must include corrective replenishment of body stores.

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