Prevalence and Predictive Signs for Gastrointestinal Lesions in Premenopausal Women with Iron Deficiency Anemia

2008 ◽  
Vol 53 (12) ◽  
pp. 3138-3144 ◽  
Author(s):  
Dan Carter ◽  
Yaacov Maor ◽  
Simon Bar-Meir ◽  
Benjamin Avidan
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Premenopausal Women ◽  
Deficiency Anemia ◽  
Gastrointestinal Lesions

scholarly journals Molecular Aspects and Treatment of Iron Deficiency in the Elderly

2020 ◽  
Vol 21 (11) ◽  
pp. 3821
Author(s):  
Antonino Davide Romano ◽  
Annalisa Paglia ◽  
Francesco Bellanti ◽  
Rosanna Villani ◽  
Moris Sangineto ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Iron Homeostasis ◽  
Diagnostic Algorithm ◽  
The Elderly ◽  
Deficiency Anemia ◽  
Clinical State ◽  
Ageing Population ◽  
Gastrointestinal Lesions ◽  
Aged Subjects

Iron deficiency (ID) is the most frequent nutritional deficiency in the whole population worldwide, and the second most common cause of anemia in the elderly. The prevalence of anemia is expecting to rise shortly, because of an ageing population. Even though WHO criteria define anemia as a hemoglobin serum concentration <12 g/dL in women and <13 g/dL in men, several authors propose different and specific cut-off values for the elderly. Anemia in aged subjects impacts health and quality of life, and it is associated with several negative outcomes, such as longer time of hospitalization and a higher risk of disability. Furthermore, it is an independent risk factor of increased morbidity and mortality. Even though iron deficiency anemia is a common disorder in older adults, it should be not considered as a normal ageing consequence, but a sign of underlying dysfunction. Relating to the molecular mechanism in Iron Deficiency Anemia (IDA), hepcidin has a key role in iron homeostasis. It downregulates the iron exporter ferroportin, inhibiting both iron absorption and release. IDA is frequently dependent on blood loss, especially caused by gastrointestinal lesions. Thus, a diagnostic algorithm for IDA should include invasive investigation such as endoscopic procedures. The treatment choice is influenced by the severity of anemia, underlying conditions, comorbidities, and the clinical state of the patient. Correction of anemia and iron supplementation should be associated with the treatment of the causal disease.

High occurrence of iron-malabsorption disorders in premenopausal women with iron deficiency anemia

2006 ◽  
Vol 38 ◽  
pp. S10
Author(s):  
L. Vannella ◽  
F. Baccini ◽  
E. Di Guilio ◽  
M.A. Aloe Spiriti ◽  
E. Lahner ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Premenopausal Women ◽  
Deficiency Anemia ◽  
High Occurrence

scholarly journals Gastrointestinal Lesions in African American Patients With Iron Deficiency Anemia

2018 ◽  
Vol 11 ◽  
pp. 117955221877862 ◽  
Author(s):  
Hassan Brim ◽  
Anahita Shahnazi ◽  
Mehdi Nouraie ◽  
Dilhana Badurdeen ◽  
Adeyinka O Laiyemo ◽  
...  
Keyword(s):  
African American ◽  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Clinical Laboratory ◽  
Demographic Data ◽  
Deficiency Anemia ◽  
Gi Bleeding ◽  
Associated Lesions ◽  
Asymptomatic Patients ◽  
Gastrointestinal Lesions

Background: Iron deficiency anemia (IDA) is a frequent disorder that is associated with many serious diseases. However, the findings of an evaluation of IDA-associated gastrointestinal disorders are lacking among African American patients. Aim: To determine the most prevalent gastrointestinal lesions among African American patients with IDA especially in young men. Methods: We reviewed medical records (n = 422) of patients referred for evaluation of IDA from 2008 to 2012. Iron deficiency anemia was diagnosed using clinical laboratory tests. The results of esophagogastroduodenoscopy, colonoscopy, and pathology specimens along with demographic data were abstracted and analyzed using Stata. Results: The mean age was 61.9 years, and 50.5% were women. In total, 189 patients (45%) had gross gastrointestinal (GI) bleeding. The most frequent diagnoses were gastritis (40%), benign colonic lesions (13%), esophagitis (9%), gastric ulcer (6%), and duodenitis (6%). GI bleeding was significantly more frequent in men ( P = 0.001). Benign and malignant colonic lesions were significantly more present among older patients: 16% vs 6% ( P = .005) and 5% vs 0% ( P = .008), respectively. Colitis was more prevalent in younger patients (⩽50): 11% vs 2% ( P = .001). In patients with gross lower GI bleeding, the top diagnoses were gastritis (25%), benign colon tumors (10%), and duodenitis (6%). Colon cancer was diagnosed among 15 patients, and all these patients were older than 50 years of age. Conclusions: Gastritis and colonic lesions are most common associated lesions with IDA among African Americans. So bidirectional endoscopy is required for unrevealing of the cause of IDA in asymptomatic patients.

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