A C-634-G Polymorphism of the Interleukin-6 Gene Promoter as a Possible Risk for Idiopathic Recurrent Miscarriage

2011 ◽  
Vol 31 (2) ◽  
pp. 277-286
Author(s):  
Ayatallah Nassef ◽  
Dina Bahgat ◽  
Fouad AboHamila
Keyword(s):  
Interleukin 6 ◽  
Recurrent Miscarriage ◽  
Gene Promoter ◽  
Idiopathic Recurrent Miscarriage

scholarly journals IL-10 gene promoter and intron polymorphisms and changes in IL-10 secretion in women with idiopathic recurrent miscarriage

2014 ◽  
Vol 29 (5) ◽  
pp. 1025-1034 ◽  
Author(s):  
R. H. Qaddourah ◽  
K. Magdoud ◽  
F. L. Saldanha ◽  
N. Mahmood ◽  
F. E. Mustafa ◽  
...  
Keyword(s):  
Recurrent Miscarriage ◽  
Gene Promoter ◽  
Idiopathic Recurrent Miscarriage

scholarly journals A modest but significant effect of CGB5 gene promoter polymorphisms in modulating the risk of recurrent miscarriage

2013 ◽  
Vol 99 (7) ◽  
pp. 1930-1936.e6 ◽  
Author(s):  
Kristiina Rull ◽  
Ole Bjarne Christiansen ◽  
Liina Nagirnaja ◽  
Rudi Steffensen ◽  
Tõnu Margus ◽  
...  
Keyword(s):  
Recurrent Miscarriage ◽  
Gene Promoter ◽  
Promoter Polymorphisms

Tumor necrosis factor-α polymorphisms in women with idiopathic recurrent miscarriage

2010 ◽  
Vol 84 (2) ◽  
pp. 186-192 ◽  
Author(s):  
R.R. Finan ◽  
Z. Al-Irhayim ◽  
F.E. Mustafa ◽  
I. Al-Zaman ◽  
F.A. Mohammed ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Recurrent Miscarriage ◽  
Idiopathic Recurrent Miscarriage ◽  
Factor Α ◽  
Necrosis Factor

-174G/C interleukin-6 gene promoter polymorphism predicts therapeutic response to etanercept in rheumatoid arthritis

2012 ◽  
Vol 33 (6) ◽  
pp. 1481-1486 ◽  
Author(s):  
Ivan Jančić ◽  
Nevena Arsenović-Ranin ◽  
Mirjana Šefik-Bukilica ◽  
Sladjana Živojinović ◽  
Nemanja Damjanov ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Interleukin 6 ◽  
Therapeutic Response ◽  
Gene Promoter ◽  
Promoter Polymorphism ◽  
Gene Promoter Polymorphism

scholarly journals Associations between tumor necrosis factor-α and lymphotoxin-α polymorphisms and idiopathic recurrent miscarriage

Reproduction ◽  
2008 ◽  
Vol 135 (3) ◽  
pp. 397-403 ◽  
Author(s):  
W Zammiti ◽  
N Mtiraoui ◽  
H Khairi ◽  
J-C Gris ◽  
W Y Almawi ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Recurrent Miscarriage ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Tnf Α ◽  
Idiopathic Recurrent Miscarriage ◽  
Factor Α ◽  
Lymphotoxin Α ◽  
Necrosis Factor

Heightened expression of tumor necrosis factor (TNF)-α and lymphotoxin-α (LT-α) was associated with pregnancy complications, including idiopathic recurrent miscarriage (RM). Whereas TNF-α and LT-α gene polymorphisms affect serum cytokine concentrations, their contribution to RM is controversial. The single nucleotide polymorphisms (SNPs) TNF-α (−238G/A, −308G/A) and LT-α (+252A/G) were investigated in 350 RM women and 200 control women. Higher frequency of the TNF-α −238A, but not the TNF-α −308A or the LT-α+252G, allele was seen in patients, with comparable frequencies of TNF-α −238G/A, TNF-α −308G/A, and LT-α+252A/G genotypes seen between both groups, except for TNF-α −238G/G, which was lower in patients. Regression analysis confirmed the association of the TNF-α −238G/A SNP with idiopathic RM, and both TNF-α −308A/TNF −238G/LT-α+252Gand TNF-α −308G/TNF-α −238A/LT-α+252Ghaplotypes played a susceptible role in idiopathic RM. TNF-α −238G/A and −238A/A, and LT-α+252G/G genotypes were positively associated only with exclusively early RM. This supports the concept of the association of TNF-α (−238G/A) and LT-α (+252A/G) polymorphic variants in idiopathic RM.

scholarly journals Methylation status of interleukin-6 gene promoter in patients with Behçet's disease

2020 ◽  
Vol 16 (3) ◽  
pp. 229-234 ◽  
Author(s):  
Shahriar Alipour ◽  
Ebrahim Sakhinia ◽  
Alireza Khabbazi ◽  
Nasser Samadi ◽  
Zohreh Babaloo ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Interleukin 6 ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Methylation Status ◽  
Gene Promoter ◽  
Behcet's Disease
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