scholarly journals Relation of progesterone and luteinizing hormone serum levels and Ultrasound endometrium criteria with intracytoplasmatic sperm injection outcome

2017 ◽  
Vol 7 (2) ◽  
pp. 55-662
1974 ◽  
Vol 75 (3) ◽  
pp. 491-496 ◽  
Author(s):  
Junichi Mori ◽  
Hiroshi Nagasawa ◽  
Reiko Yanai ◽  
Junji Masaki

ABSTRACT The sequence of changes in the serum levels of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from 2 days before to 24 h after parturition of primiparous Sprague-Dawley rats was investigated by radioimmunoassay. No appreciable change in average serum FSH levels was observed during 2 days before and 1 h after parturition. After this the levels increased gradually to show a peak at 7 h after parturition and then declined gradually until 24 h after parturition. However, the level at 24 h after parturition was still twice as high as that at parturition (0 h). The average serum LH levels which were low between 2 days before and 1 h after parturition, showed a peak at 7 h and decreased toward 13 h after parturition. The same levels as at parturition were maintained between 13 and 24 h after parturition. The time of surge of either FSH or LH was closely related to the time after parturition. There were some differences between FSH and LH in the patterns of sequence of changes in the serum levels near parturition.


2018 ◽  
Vol 23 ◽  
pp. 2515690X1879605 ◽  
Author(s):  
Nourollah Rezaei ◽  
Tahereh Mardanshahi ◽  
Majid Malekzadeh Shafaroudi ◽  
Saeed Abedian ◽  
Hamid Mohammadi ◽  
...  

The present study was designed to investigate the antioxidant property of l-carnitine (LC) on serum levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone (TH) and testis oxidative stress in streptozotocin (STZ)-induced diabetic rats. The rats were divided into the following groups: group I, control; group II, LC 100 mg/kg/d; group III, diabetic; and groups IV to VI, diabetic rats treated with 50, 100, and 200 mg/kg/d of LC, respectively. Daily injections were given intraperitoneally for 7 weeks. At the end of experimental period, after sacrificing the rats, FSH, LH, TH, total antioxidant capacity (TAC), malondialdehyde (MDA), glutathione (GSH), catalase (CAT), mitochondrial function (MTT), protein carbonyl (PC), and reactive oxygen species (ROS) levels were measured. STZ caused an elevation of MDA, ROS, and PC ( P < .001) with reduction of GSH, CAT, TAC, and MTT ( P < .001) in the serum levels. Group VI had significantly increased FSH, LH, and TH levels versus the untreated diabetic group ( P < .001). Although groups V and VI significantly decreased MDA ( P < .001), PC ( P < .01), and ROS ( P < .01) compared with the untreated diabetic group; only in group VI, the activity of GSH ( P < .001), CAT ( P < .01), TAC ( P < .001), and MTT ( P < .001) significantly increased. The results of the present study suggest that LC decreased diabetes-induced oxidative stress complications and also improved serum level of FSH, LH, and TH by reducing levels of lipid peroxidation and increasing antioxidant enzymes.


2020 ◽  
Vol 4 (11) ◽  
Author(s):  
Karin Eriksson ◽  
Leif Wide

Abstract Context The progestins of the levonorgestrel family are 13-ethylgonane progestins, commonly used for contraception in women. One contraceptive effect of these progestins is inhibition of ovulation, which may be a result of changes in gonadotropin glycosylation patterns. Gonadotropin glycoforms differ in number of glycans and bioactivity: more bioactive low-N-glycosylated glycoforms, diglycosylated luteinizing hormone (LHdi) and triglycosylated follicle-stimulating hormone (FSHtri), and less bioactive fully N-glycosylated glycoforms, LHtri and FSHtetra. Objective Characterize the glycosylation patterns on the circulating gonadotropin glycoforms in women using 13-ethylgonane progestins for contraception. Design, Subjects, Main Outcome Measures Serum samples, collected from 92 healthy women using 13-ethylgonane progestins for contraception, were included. Forty women used progestin-only continuously and 52 used progestins combined with ethinylestradiol (EE) for 3 weeks followed by a hormone-free week. Concentration, sulfonation, and sialylation of each glycoform were determined and compared with follicular phase values of normal menstrual cycles. Results The progestin-only group had significantly increased serum levels, decreased sulfonation, and increased sialylation of LHdi. The LHdi/FSHtri ratio was increased. The progestin+EE group had significantly decreased gonadotropin glycoform concentrations and decreased sialylation of FSHtri. The progestin+EE effect on sialylation of FSHtri occurred later during the treatment cycle in contrast to the effect on FSHtri concentration. Conclusions The 2 different progestin treatments induced different effects on the glycan synthesis and concentrations of more bioactive low-glycosylated gonadotropins. Progestin-only treatment increased sialylation and decreased sulfonation of LHdi molecules, contributing to sustained higher levels of bioactive LHdi molecules. Progestin+EE treatment decreased sialylation of FSHtri, contributing to a shorter half-life and decreased levels of bioactive FSHtri.


2012 ◽  
Vol 44 (08) ◽  
pp. 632-638 ◽  
Author(s):  
M. Laconi ◽  
C. Chavez ◽  
J. Cavicchia ◽  
M. Fóscolo ◽  
Z. Sosa ◽  
...  

1978 ◽  
Vol 76 (3) ◽  
pp. 417-425 ◽  
Author(s):  
C. A. BLAKE ◽  
PATRICIA K. BLAKE ◽  
NANCY K. THORNEYCROFT ◽  
I. H. THORNEYCROFT

The effects of coitus and injection of luteinizing hormone releasing hormone (LH-RH) on serum concentrations of LH, testosterone and dihydrotestosterone (17β-hydroxy-5α-androstan-3-one; DHT) were tested in male rabbits. Before experimentation, male and female rabbits were housed in individual cages in the same room. Male rabbits were then bled by cardiac puncture before and after placement with female rabbits or intravenous injection of LH-RH. Serum LH, testosterone and DHT were measured by radioimmunoassay. Sexual excitement (sniffing, chasing and mounting), with or without intromission, caused a marked rise in serum testosterone and DHT concentrations in only some of the bucks. These increases were accompanied or preceded by a small, transient increase in serum LH. In the rest of the bucks, sexual excitement with or without intromission had either no effect on serum levels of all three hormones, or only serum testosterone and DHT decreased during the collection period. Similar responses were measured in bucks which were housed in a room without does for 2–4 weeks before experimentation. Injection of 10, 30 or 100 ng or 50 μg LH-RH caused serum LH, testosterone and DHT to rise in all bucks tested, but the magnitude of the rises in serum testosterone and DHT were not related to the magnitude of the LH rise. In both mated and LH-RH-injected bucks, the rises in serum testosterone and DHT were greatest in animals with low initial testosterone and DHT values. Under the conditions of this study, the data suggest that: (1) serum testosterone and DHT rise in only some male rabbits after sexual excitement (with or without intromission), (2) the rises in serum testosterone and DHT are dependent on a small transient increase in serum LH and (3) sexual excitement is less likely to cause release of LH-RH in bucks with raised serum testosterone and DHT concentrations.


2018 ◽  
Vol 4 (4) ◽  
pp. 591-598 ◽  
Author(s):  
Mikkel Bandak ◽  
Niels Jørgensen ◽  
Anders Juul ◽  
Jakob Lauritsen ◽  
Maria Gry Gundgaard Kier ◽  
...  

1981 ◽  
Vol 96 (3) ◽  
pp. 370-376 ◽  
Author(s):  
G. Freundl ◽  
R. Terinde ◽  
W. Distler ◽  
A. Baumeister ◽  
J. Herberger ◽  
...  

Abstract. Serum levels of oestradiol-17β (Oe2), luteinizing hormone (LH) and progesterone (P) in 20 healthy women were correlated to the size of the ripening follicle during the follicular phase of normal menstrual cycles. Growing follicles were measured by ultrasound using the full bladder technique. In each individual case a good correlation (r = 0.88) between the Oe2 values and the size of the maturing follicle was found. However, since all women examined ovulated at a different Graafian follicle diameter (range 17 to 26 mm), the corresponding Oe2 values showed quite a large variation (range 0.78 to 2.5 nmol/l). The cervical score correlated to follicular maturation up to a follicle size of 19 mm (maximal cervical reaction). From then on no further improvement of the cervical parameters could be observed. We conclude that ultrasound monitoring of follicular growth can be a useful addition to the Oe2 and P measurements in the clinical management of the infertile woman. Bifollicular maturation can be diagnosed early, when the endocrinological data are combined with follicle size. Moreover, a correlation can be made between follicular growth and oestradiol production in the individual cycle.


1991 ◽  
Vol 69 (4) ◽  
pp. 1004-1009 ◽  
Author(s):  
J. Vriend

Gonadal involution, with reduced serum levels of luteinizing hormone and prolactin, was induced in male Syrian hamsters by daily injections of melatonin, given in the evening. Highly significant increases in daytime concentrations of 5-hydroxyindoleacetic acid (5-HIAA) and in the ratio of 5-HIAA to serotonin (5-HT) were noted in extracts of mediobasal hypothalamus of melatonin-treated hamsters. An increase in the 5-HIAA/5-HT ratio, with decreased 5-HT concentrations, was found in brainstem extracts of hamsters treated with melatonin. The increase in the 5-HIAA/5-HT ratio was not prevented by inhibition of catecholamine synthesis with α-methyl-p-tyrosine, which suggests that the melatonin-induced increase in the 5-HIAA/5-HT ratio was not due to changes in catecholamine turnover. These results are consistent with the view that serotonergic neurons terminating in the hypothalamus mediate the melatonin-induced inhibition of luteinizing hormone, prolactin, and thyroid hormones accompanying gonadal involution.


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