scholarly journals Study of the Value of Urinary Vitamin D-Binding Protein as a Prognostic Biomarker in Cases of Childhood Idiopathic Nephrotic Syndrome and its Relation to Calcium /Phosphorus Metabolism.

GEGET ◽  
2021 ◽  
Vol 16 (1) ◽  
pp. 71-82
Author(s):  
Mohammad Sharaf ◽  
Khaled Awwad ◽  
Asmaa Awad Gad El Rab ◽  
Dina Ragab
Keyword(s):  
Vitamin D ◽  
Nephrotic Syndrome ◽  
Prognostic Biomarker ◽  
Idiopathic Nephrotic Syndrome ◽  
Binding Protein ◽  
Phosphorus Metabolism ◽  
Vitamin D Binding Protein ◽  
Calcium Phosphorus

scholarly journals Urinary Vitamin D-Binding Protein as a Biomarker of Steroid-Resistant Nephrotic Syndrome

2016 ◽  
Vol 11 ◽  
pp. BMI.S31633 ◽  
Author(s):  
Michael R. Bennett ◽  
Angad Pordal ◽  
Christopher Haffner ◽  
LaTawnya Pleasant ◽  
Qing Ma ◽  
...  
Keyword(s):  
Vitamin D ◽  
Nephrotic Syndrome ◽  
Binding Protein ◽  
Area Under The Curve ◽  
Vitamin D Binding Protein ◽  
Cross Sectional ◽  
Steroid Resistant ◽  
Steroid Resistant Nephrotic Syndrome ◽  
Urine Creatinine ◽  
Normal Controls

Background Idiopathic nephrotic syndrome (NS) is one of the most common glomerular disorders of childhood and is associated with increased urinary vitamin D-binding protein (uVDBP) excretion. We tested the hypothesis that uVDBP represents a biomarker to differentiate steroid-resistant nephrotic syndrome (SRNS) from the more benign forms of steroid-sensitive nephrotic syndrome (SSNS). Methods This cross-sectional study included children with SRNS ( n = 24), SSNS ( n = 28), and normal controls ( n = 5). Urine and clinical data were collected from patients. Measurements of uVDBP were performed with a commercially available ELISA kit and normalized to urine creatinine. Results Concentrations of uVDBP were significantly higher ( P < 0.001) in patients with SRNS (13,659 ng/mL, interquartile range [IQR] 477–22,979) than in patients with SSNS (94 ng/mL, IQR 53–202) and normal controls (23 ng/mL, IQR 22–99, P = 0.002). Significance did not change when the results were corrected for urine creatinine. uVDBP was significantly negatively correlated with estimated glomerular filtration rate (eGFR; R = −0.76, P = 0.03). However, uVDBP was still markedly elevated in patients with SRNS with eGFR >100 mL/minute/1.73 m2. There was a positive correlation between microalbuminuria (MALB/Cr) and uVDBP ( R = 0.67, P < 0.001). However, uVDBP displayed a much higher discriminatory ability for distinguishing SRNS than MALB/Cr (area under the curve = 0.92 vs 0.67, respectively). An uVDBP cutoff of 362 ng/mL yielded the optimal sensitivity (80%) and specificity (83%) to distinguish SRNS from SSNS. Conclusions In this preliminary study, uVDBP represents a noninvasive biomarker that could distinguish SRNS from the more benign SSNS with high discriminatory power.

Studies on vitamin D binding protein in the nephrotic syndrome.

1985 ◽  
Vol 31 (5) ◽  
pp. 718-721 ◽  
Author(s):  
K Colston ◽  
N J Williams ◽  
H J Cleeve
Keyword(s):  
Vitamin D ◽  
Nephrotic Syndrome ◽  
Gradient Analysis ◽  
Dissociation Constants ◽  
Binding Capacity ◽  
Specific Binding ◽  
Binding Protein ◽  
Normal Subjects ◽  
Sucrose Density Gradient ◽  
Vitamin D Binding Protein

Abstract We studied the properties of vitamin D binding protein in plasma and urine from nine patients with nephrotic syndrome. Samples were incubated with 25-[3H]hydroxyvitamin D3, after which we determined binding capacity and apparent dissociation constants. Binding capacity was markedly less in plasma from patients with nephrotic syndrome than that from normal subjects, but binding affinity was unchanged. Specific binding of 25-hydroxy[3H]vitamin D3 could be demonstrated in urine from all the nephrotic patients, and sucrose density-gradient analysis of these urines revealed a single binding peak with sedimentation characteristics similar to those of vitamin D binding protein in plasma.

Longitudinal increase in vitamin D binding protein levels after initiation of tenofovir/lamivudine/efavirenz therapy among HIV-infected individuals

2016 ◽  
Author(s):  
Evelyn Hsieh ◽  
Liana Fraenkel ◽  
Yang Han ◽  
Weibo Xia ◽  
Karl Insogna ◽  
...  
Keyword(s):  
Vitamin D ◽  
Binding Protein ◽  
Vitamin D Binding Protein ◽  
Protein Levels

Longitudinal increase in vitamin D binding protein levels after initiation of tenofovir/lamivudine/efavirenz therapy among HIV-infected individuals

2016 ◽  
Author(s):  
Evelyn Hsieh ◽  
Liana Fraenkel ◽  
Yang Han ◽  
Weibo Xia ◽  
Karl Insogna ◽  
...  
Keyword(s):  
Vitamin D ◽  
Binding Protein ◽  
Vitamin D Binding Protein ◽  
Protein Levels

Vitamin D binding protein (DBP) is required for pro-invasion effects of vitamin D on placental trophoblastic cells

2019 ◽  
Author(s):  
Ankana Ganguly ◽  
Alexandra Shattock ◽  
Annsha Joseph ◽  
Janesh Gupta ◽  
Martin Hewison
Keyword(s):  
Vitamin D ◽  
Binding Protein ◽  
Vitamin D Binding Protein ◽  
Trophoblastic Cells

scholarly journals Vitamin D receptor, vitamin D binding protein and CYP27B1 single nucleotide polymorphisms and susceptibility to viral infections in infants

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Maria Zacharioudaki ◽  
Ippokratis Messaritakis ◽  
Emmanouil Galanakis
Keyword(s):  
Vitamin D ◽  
Single Nucleotide Polymorphisms ◽  
Viral Infection ◽  
Vitamin D Receptor ◽  
Viral Infections ◽  
Binding Protein ◽  
Genotypic Differences ◽  
Nucleotide Polymorphisms ◽  
Vitamin D Binding Protein ◽  
Single Nucleotide

AbstractThe role of vitamin D in innate and adaptive immunity is recently under investigation. In this study we explored the potential association of genetic variances in vitamin D pathway and infections in infancy. Τhis prospective case–control study included infants 0–24 months with infection and age-matched controls. The single nucleotide polymorphisms of vitamin D receptor (VDR) gene (BsmI, FokI, ApaI, TaqI), vitamin D binding protein (VDBP) (Gc gene, rs7041, rs4588) and CYP27B1 (rs10877012) were genotyped by polymerase chain reaction-restriction fragment length polymorphism. In total 132 infants were enrolled, of whom 40 with bacterial and 52 with viral infection, and 40 healthy controls. As compared to controls, ΤaqI was more frequent in infants with viral infection compared to controls (p = 0.03, OR 1.96, 95% CI 1.1–3.58). Moreover, Gc1F was more frequent in the control group compared to infants with viral infection (p = 0.007, OR 2.7, 95% CI 1.3–5.6). No significant differences were found regarding the genetic profile for VDR and VDBP in infants with bacterial infection compared to the controls and also regarding CYP27B1 (rs10877012) between the studied groups. Genotypic differences suggest that vitamin D pathway might be associated with the host immune response against viral infections in infancy.

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