scholarly journals Differential effect of high fat diet (HFD) on the cardiac muscle of adult and aged female mice and the possible protective role of artichoke treatment: Histomorphometric and ultrastructural study

2019 ◽  
Vol 3 (1) ◽  
pp. 36-54
Author(s):  
Asmaa Dawood ◽  
Hemmat Hareedy
Keyword(s):  
Cardiac Muscle ◽  
Ultrastructural Study ◽  
High Fat Diet ◽  
Differential Effect ◽  
Protective Role ◽  
High Fat ◽  
Female Mice

scholarly journals Mechanistic role of antioxidants in rescuing delayed gastric emptying in high fat diet induced diabetic female mice

2021 ◽  
Vol 137 ◽  
pp. 111370
Author(s):  
Chethan Sampath ◽  
Derek Wilus ◽  
Mohammad Tabatabai ◽  
Michael L. Freeman ◽  
Pandu R. Gangula
Keyword(s):  
Gastric Emptying ◽  
High Fat Diet ◽  
Delayed Gastric Emptying ◽  
High Fat ◽  
Female Mice

scholarly journals Role of human pregnane X receptor in high fat diet-induced obesity in pre-menopausal female mice

2014 ◽  
Vol 89 (3) ◽  
pp. 399-412 ◽  
Author(s):  
Krisstonia Spruiell ◽  
Dominique Z. Jones ◽  
John M. Cullen ◽  
Emmanuel M. Awumey ◽  
Frank J. Gonzalez ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Pregnane X Receptor ◽  
High Fat ◽  
Female Mice ◽  
Diet Induced Obesity

Protective role of adiponectin against testicular impairment in high-fat diet/streptozotocin-induced type 2 diabetic mice

Biochimie ◽  
2020 ◽  
Vol 168 ◽  
pp. 41-52 ◽  
Author(s):  
Mayank Choubey ◽  
Ashutosh Ranjan ◽  
Puran S. Bora ◽  
Amitabh Krishna
Keyword(s):  
High Fat Diet ◽  
Protective Role ◽  
Diabetic Mice ◽  
High Fat ◽  
Testicular Impairment ◽  
Type 2 Diabetic

scholarly journals Differential effect of high fat diet on tissue morphology and hormonal levels in male and female mice (765.1)

2014 ◽  
Vol 28 (S1) ◽  
Author(s):  
Nicole Wong ◽  
Laxminarasimha Donthireddy ◽  
Sathyapriya Babu ◽  
Debasis Adhikary ◽  
Sanjoy Chakraborty ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Differential Effect ◽  
High Fat ◽  
Male And Female ◽  
Female Mice ◽  
Tissue Morphology ◽  
Hormonal Levels

Abstract 265: Platelet C-Type Lectinlike (CLEC)-2 Receptor Plays a Protective Role Against Development of Atherosclerosis in Atherosclerosis-Prone Mice

2014 ◽  
Vol 34 (suppl_1) ◽  
Author(s):  
Marie Lordkipanidze ◽  
Matthew J Harrison ◽  
Steve P Watson ◽  
G E Rainger
Keyword(s):  
High Fat Diet ◽  
Blood Lipid ◽  
Protective Role ◽  
Plaque Burden ◽  
Platelet Glycoprotein ◽  
High Fat ◽  
T Helper 17 ◽  
Platelet Surface ◽  
Atherosclerotic Lesions

Background: Platelets can influence progression of plaque formation by facilitating recruitment of inflammatory cells at the sites of atherosclerotic lesions. A C-type lectin-like receptor, CLEC-2, abundantly expressed on the platelet surface, has been shown to regulate lymphatic development in utero though an interaction with Podoplanin. Interestingly, lymphatic vasculature is increased in ischemic and inflamed hearts, and in cholesterol-rich atherosclerotic lesions. Moreover, Podoplanin expression is up-regulated on inflammatory macrophages and on T-helper 17 cells. However, the role of the Podoplanin - CLEC-2 interaction in atherosclerosis remains unknown. Aim: We sought to investigate the role of CLEC-2 on atherosclerotic development in ApoE-deficient mice. Methods: CreERT.CLEC-2fl/fl x ApoE-/- and litter-matched ApoE-/- mice were treated with tamoxifen at the age of 9 weeks and were put on a high-fat diet for 6 weeks. Animals were killed at the age of 16 weeks, when platelet function assays and atherosclerosis assays were carried out. Results: Expression of CLEC-2 was abolished in tamoxifen-treated CreERT.CLEC-2fl/fl x ApoE-/- mice (n=8), whereas normal levels were seen in ApoE-/- controls (n=10) also treated with tamoxifen. CreERT.CLEC-2fl/fl x ApoE-/- and ApoE-/- mice had similar baseline characteristics, comparable levels of platelet glycoprotein expression (GPIb, GPIIbIIIa and GPVI) and normal platelet responses to platelet agonists (collagen-related peptide, PAR-4 peptide, ADP and arachidonic acid). Blood lipid levels were comparable between CreERT.CLEC-2fl/fl x ApoE-/- and control animals. Atherosclerotic plaque burden was significantly higher in the aortas of CreERT.CLEC-2fl/fl x ApoE-/- mice fed a high-fat diet for 6 weeks compared with their ApoE-/- counterparts. The higher plaque burden was seen consistently throughout the aorta, but reached significance at the level of whole aorta, abdominal aorta, outer curvature and the left subclavian region. This was seen in both male and female animals. Conclusions: The platelet-borne CLEC-2 receptor appears to have a protective role against atherogenesis in atheroprone mice. Further research to investigate the underlying mechanisms is warranted.

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