Behavior of New and Promising Egyptian Garlic Clones Resulting from Clonal Selection Program

2021 ◽  
Vol 12 (11) ◽  
pp. 1255-1260
Author(s):  
E. I. Ragheb ◽  
E. M. Helmy
Author(s):  
Robin R. Szarmach ◽  
Jean Livingston ◽  
George T. Rodeheaver ◽  
John G. Thacker ◽  
Richard Edlich

2011 ◽  
Vol 33 (7) ◽  
pp. 1561-1567 ◽  
Author(s):  
Xiao-fei Wang ◽  
Yue-bing Chen ◽  
Xi Zhang ◽  
Quan Zhang ◽  
Chao-jing Tang

Blood ◽  
2019 ◽  
Vol 133 (13) ◽  
pp. 1436-1445 ◽  
Author(s):  
Jyoti Nangalia ◽  
Emily Mitchell ◽  
Anthony R. Green

Abstract Interrogation of hematopoietic tissue at the clonal level has a rich history spanning over 50 years, and has provided critical insights into both normal and malignant hematopoiesis. Characterization of chromosomes identified some of the first genetic links to cancer with the discovery of chromosomal translocations in association with many hematological neoplasms. The unique accessibility of hematopoietic tissue and the ability to clonally expand hematopoietic progenitors in vitro has provided fundamental insights into the cellular hierarchy of normal hematopoiesis, as well as the functional impact of driver mutations in disease. Transplantation assays in murine models have enabled cellular assessment of the functional consequences of somatic mutations in vivo. Most recently, next-generation sequencing–based assays have shown great promise in allowing multi-“omic” characterization of single cells. Here, we review how clonal approaches have advanced our understanding of disease development, focusing on the acquisition of somatic mutations, clonal selection, driver mutation cooperation, and tumor evolution.


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