Abstract Objective: Obesity was once a rare problem in Type 1 diabetes
mellitus, but is a growing problem today. The aim of our study is to
determine the frequency of overweight / obesity at the time of diagnosis
and during follow-up in children with type 1 diabetes mellitus as well
as review the conditions that may accompany. Methods: 315 patients with
type 1 diabetes mellitus were retrospectively analyzed. The patients
were divided into two groups according to the last examination as normal
weight and overweight / obese. The two groups were compared in terms of
age at diagnosis, gender, birth weight, family history, anthropometric
measurements, insulin dose used and blood pressure measurements, and
insulin, c-peptide, hemoglobin A1c, triglyceride, and high-density
lipoprotein levels at the time of diagnosis and follow-up. Results: The
prevalence of overweight / obese in all patients was 4.8% at the time
of diagnosis, while it was 9.8% at the last examination. The height,
weight and BMI SD scores and c-peptide levels at the time of diagnosis
of the overweight / obese group were higher than those with normal
weight (p <0.001 and p = 0.008, respectively). The frequency
of dyslipidemia and hypertension was higher in the overweight / obese
group than in the normal weight group [18.2% versus 5% (p = 0.015)
and 10% versus 1.5% (p = 0.003), respectively]. Conclusion: In our
study, the fact that the overweight / obese group had higher BMI and
c-peptide and lower HDL values at the time of diagnosis can be evaluated
as indicators that insulin resistance syndrome can accompany T1DM from
the beginning (double diabetes). When determining the treatment and
follow-up strategies of patients with type 1 diabetes mellitus,
considering the risk of obesity and taking the necessary precautions is
very important in terms of morbidity.
Comparison of proinsulin and C-peptide secretion in healthy versus long-standing type 1 diabetes mellitus cohorts: A pilot study
