Miss AN, female, 17 years old, Muslim, Betawi ethnicity, graduated fromelementary school, currently no longer in school. The first febrile seizure patient wasfour years old. Five to seven years old, patients with recurrent seizures without fever,diagnosed with epilepsy and do not see a doctor regularly. At 14 years, the patient wasraped, and since then, the patient has had free sex with many different men. At the ageof,16, the patient had seizures up to five times an ay, and one seizure wasapproximately five minutes. The patient went to a neurologist and was regularly treatedwith valproic acid and carbamazepine. At the age of 17 years, the patient often gotangry when teased and threatened with knives or scissors, had free sex with many menand went to a psychiatrist. The patient has been treated five times in different mentalhospitals because he often runs away from home. Currently, the patient is being treatedin the psychiatric ward and is receiving 2 x 500 mg of valproic acid, 3 x 200 mg ofcarbamazepine, 2 x 0.5 mg of Clonazepam and 1 x 50 mg of sertraline. At the time oftreatment, the patient is known to be HIV positive and does not need ARV therapy.Patients also planned behavioural therapy and involved patients with activities atYayasan Pelita Ilmu. It is hoped that this therapy can help overcome the patient'sbehavioural and emotional problems.
Lower dolutegravir plasma concentrations in HIV-positive patients receiving valproic acid
