"Triptans and ergot derivatives are associated with an increased risk of drug dependence,"

Background and Objectives: Evidence indicates that mood disorders often co-occur with substance-related disorders. However, pooling comorbidity estimates can be challenging due to heterogeneity in diagnostic criteria and in the overall study design. The aim of this study was to systematically review and, where appropriate, meta-analyse estimates related to the pairwise comorbidity between mood disorders and substance-related disorders, after sorting these estimates by various study designs. Methods: We searched PubMed (MEDLINE), Embase, CINAHL and Web of Science for publications between 1980 and 2017 regardless of geographical location and language. We meta-analysed estimates from original articles in 4 broadly defined mood and 35 substance-related disorders. Results: After multiple eligibility steps, we included 120 studies for quantitative analysis. In general, regardless of variations in diagnosis type, temporal order or use of adjustments, there was substantial comorbidity between mood and substance-related disorders. We found a sixfold elevated risk between broadly defined mood disorder and drug dependence (odds ratio = 5.7) and fivefold risk between depression and cannabis dependence (odds ratio = 4.9) while the highest pooled estimate, based on period prevalence risk, was found between broadly defined dysthymic disorder and drug dependence (odds ratio = 11.3). Based on 56 separate meta-analyses, all pooled odds ratios were above 1, and 46 were significantly greater than 1 (i.e. the 95% confidence intervals did not include 1). Conclusion: This review found robust and consistent evidence of an increased risk of comorbidity between many combinations of mood and substance-related disorders. We also identified a number of under-researched mood and substance-related disorders, suitable for future scrutiny. This review reinforces the need for clinicians to remain vigilant in order to promptly identify and treat these common types of comorbidity.

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Psychosis and drug dependence: results from a national survey of prisoners

The British Journal of Psychiatry ◽

10.1192/bjp.181.5.393 ◽

2002 ◽

Vol 181 (5) ◽

pp. 393-398 ◽

Cited By ~ 82

Author(s):

M. Farrell ◽

A. Boys ◽

P. Bebbington ◽

T. Brugha ◽

J. Coid ◽

...

Keyword(s):

Drug Dependence ◽

Prison Population ◽

Prognostic Significance ◽

Negative Relationship ◽

Self Report ◽

Regression Analyses ◽

Heroin Use ◽

Increased Risk ◽

The Relationship ◽

Reduced Risk

BackgroundThe links between drug use and psychosis are of major aetiological and prognostic significance. Psychosis and drug dependence frequently co-occur within the prison population, providing the opportunity to study this link more closely.AimsTo explore the relationship between psychosis and drug dependence in a sample of prisoners.MethodA total of 3142 prisoners were surveyed nationally and structured clinical data were obtained from a subsample of 503 respondents. Psychiatric assessment was based on the Schedules for Clinical Assessment in Neuropsychiatry (version 1.0). Measures of amphetamine, cannabis, cocaine and heroin use and dependence were obtained through self-report.ResultsLogistic regression analyses indicated that first use of amphetamines or cocaine before the age of 16 years and severe cannabis or cocaine dependence were related to an increased risk of psychosis. In contrast, severe dependence on heroin was associated with a reduced risk of this classification.ConclusionsSevere dependence on cannabis and psychostimulants is associated with a higher risk of psychosis and is in contrast to severe dependence on heroin, which has a negative relationship with psychosis.

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Chronic hepatitis C infection in pregnant women from a drug dependence and treatment program: Increased risk for cholestasis of pregnancy and preterm delivery

American Journal of Obstetrics and Gynecology ◽

10.1016/j.ajog.2006.10.116 ◽

2006 ◽

Vol 195 (6) ◽

pp. S43

Author(s):

Eliza Berkley ◽

Kimberly Leslie ◽

Sanjeev Arora ◽

Clifford Qualls ◽

Jeffrey Dunkelberg

Keyword(s):

Chronic Hepatitis ◽

Hepatitis C ◽

Pregnant Women ◽

Preterm Delivery ◽

Chronic Hepatitis C ◽

Treatment Program ◽

Drug Dependence ◽

Hepatitis C Infection ◽

Increased Risk ◽

Cholestasis Of Pregnancy

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Drug dependence associated with triptans and ergot derivatives: a case/non-case study

European Journal of Clinical Pharmacology ◽

10.1007/s00228-009-0769-6 ◽

2009 ◽

Vol 66 (4) ◽

pp. 413-417 ◽

Cited By ~ 10

Author(s):

Frédérique Beau-Salinas ◽

Annie Pierre Jonville-Béra ◽

Haware Cissoko ◽

Lamiae Bensouda-Grimaldi ◽

Elisabeth Autret-Leca

Keyword(s):

Drug Dependence ◽

Ergot Derivatives

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Alcohol and illicit drug dependence among parents: associations with offspring externalizing disorders

Psychological Medicine ◽

10.1017/s0033291708003085 ◽

2008 ◽

Vol 39 (1) ◽

pp. 149-155 ◽

Cited By ~ 68

Author(s):

N. R. Marmorstein ◽

W. G. Iacono ◽

M. McGue

Keyword(s):

Drug Dependence ◽

Illicit Drugs ◽

Illicit Drug ◽

Externalizing Disorders ◽

Late Adolescent ◽

Externalizing Psychopathology ◽

Adolescent Offspring ◽

Oppositional Defiant ◽

Increased Risk ◽

Parental Alcohol

BackgroundPrevious research indicates that alcohol and drug dependence constitute aspects of a general vulnerability to externalizing disorders that accounts for much of the parent-offspring resemblance for these and related disorders. This study examined how adolescent offspring risk for externalizing psychopathology varies with respect to parental alcoholism and illicit drug dependence.MethodData from the Minnesota Twin Family Study, a community-based investigation of adolescents (age 17 years, n=1252) and their parents, were used. Lifetime diagnoses of alcohol and drug dependence (among both parents and offspring) and offspring attention deficit hyperactivity disorder, oppositional defiant disorder, conduct disorder, adult antisocial behavior, and nicotine dependence were assessed via structured interviews.ResultsParental alcohol dependence and parental drug dependence were similarly associated with increased risk for nearly all offspring disorders, with offspring of alcohol and drug-dependent parents having approximately 2–3 times the odds for developing a disorder by late adolescence compared to low-risk offspring. Compared to parental dependence on other illicit drugs, parental cannabis dependence was associated with weaker increased risk for offspring externalizing disorders.ConclusionsBoth parental alcohol and drug dependence are independently associated with an increased risk for a broad range of externalizing psychopathology among late-adolescent offspring.

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