Drug-eluting stents are cost saving among patients with a high in-stent restenosis risk,

2007 ◽  
Vol 538 (1) ◽  
pp. 4-4
Keyword(s):  
Cost Saving ◽  
Drug Eluting Stents ◽  
Stent Restenosis ◽  
Drug Eluting ◽  
In Stent Restenosis

scholarly journals In-stent restenosis of drug-eluting stents: clinical presentation and outcomes in a real-world scenario

2019 ◽  
Vol 71 (1) ◽  
Author(s):  
Ganesh Paramasivam ◽  
Tom Devasia ◽  
Shabeer Ubaid ◽  
Ashwitha Shetty ◽  
Krishnananda Nayak ◽  
...  
Keyword(s):  
Real World ◽  
Clinical Presentation ◽  
Drug Eluting Stents ◽  
Stent Restenosis ◽  
Drug Eluting ◽  
In Stent Restenosis

scholarly journals Drug-Eluting Balloons versus Second-Generation Drug-Eluting Stents for Treating In-Stent Restenosis in Coronary Heart Disease after PCI: A Meta-Analysis

2018 ◽  
Vol 2018 ◽  
pp. 1-14 ◽  
Author(s):  
Wen-Juan Xiu ◽  
Hai-Tao Yang ◽  
Ying-Ying Zheng ◽  
Yi-Tong Ma ◽  
Xiang Xie
Keyword(s):  
Observational Studies ◽  
Second Generation ◽  
Meta Analysis ◽  
Drug Eluting Stents ◽  
Randomized Controlled ◽  
Stent Restenosis ◽  
Significant Difference ◽  
Drug Eluting ◽  
In Stent Restenosis

Background. In-stent restenosis (ISR) remains a common problem following percutaneous coronary intervention (PCI). However, the best treatment strategy remains uncertain. There is some controversy over the efficacy of drug-eluting balloons (DEBs) and second-generation drug-eluting stents (DESs) for treating ISR. Methods. A meta-analysis was used to compare the efficacy of the DEB and second-generation DES in the treatment of ISR. The primary endpoint is the incidence of target lesion revascularization (TLR). The secondary endpoint is the occurrence of target vessel revascularization (TVR), myocardial infarction (MI), all-cause death (ACM), cardiac death (CD), major adverse cardiac events (MACEs), minimum luminal diameter (MLD), late luminal loss (LLL), binary restenosis (BR), and percent diameter stenosis (DS%). Results. A total of 12 studies (4 randomized controlled trials and 8 observational studies) including 2020 patients with a follow-up of 6–25 months were included in the present study. There was a significant difference in the MLD between the two groups during follow-up (P=0.007, RR = 0.23, and 95% CI: 0.06–0.4 mm). There was no significant difference in LLL, BR, or DS% and the overall incidence of MACEs between the two groups. Subgroup analysis showed no significant difference in the incidence of primary and secondary endpoints when considering RCTs or observational studies only. Conclusions. The efficacy of the DEB and second-generation DES in the treatment of ISR is comparable. However, our results need further verification through multicenter randomized controlled trials.

scholarly journals Predictive value of the CHA2DS2-VASc Score in detecting in-stent restenosis among patients who underwent previous revascularization due to stable angina or acute coronary syndromes

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
R Ayman ◽  
H Shehata ◽  
E AL-Fikki ◽  
Y Gomaa
Keyword(s):  
Significant Relationship ◽  
Stable Angina ◽  
Predictive Value ◽  
Long Term Results ◽  
Drug Eluting Stents ◽  
P Value ◽  
Stent Restenosis ◽  
Stent Length ◽  
Drug Eluting ◽  
In Stent Restenosis

Abstract Background Introduction of coronary stents in the field of interventional cardiology has significantly improved short- and long-term results of the percutaneous coronary interventions but in the same time they became responsible for development of a new entity called neo-intimal hyperplasia (NIH). If overexpressed, NIH can lead to so-called in-stent restenosis (ISR). Objective To assess the predictive value of the CHA2DS2-VASc Score in detecting in-stent restenosis among patients who underwent previous revascularization in Proximal Left Anterior Descending(LAD) Artery using Drug Eluting Stents (DES) due to stable angina and acute coronary syndrome. Material and Methods This study was conducted over 113 pateints to assess the predictive value of the CHA2DS2-VASc Score in detecting in-stent restenosis among patients who underwent previous revascularization in Proximal Left Anterior Descending (LAD) Artery using Drug Eluting Stents (DES). Results From the study population collected(n = 113), 18.4% of which were females (n = 21), statistically significant relation was found between DES-ISR and CHADSVasc score (p value =0.033). A significant relationship existed between ISR and CHADVasc score 3 or more, and each of: Age(p value= 0.022), DM(p value=0.029), SBP during the procedure(p value = 0.036), time since the PCI was done(p value =0.001), stent length(p value=0.028), pattern of the lesion and management of the lesions as individual variables (p value less than0.001). However, non-significant relationship could be concluded between ISR and each of gender(p value= 0.987), CHF(p value=0.163), HTN(p value=0.446), vascular diseases (p value=0.662), CAD type (SCAD or ACS)(p value=0.616), DBP during the procedure(p value=0.167), creatinine clearance (p value=0.69), HBA1c(p value=0.091), use of DAPT(p value=0.198), the duration of DAPT use(p value=0.873), type of P2Y12 inhibitor used(p value=0.083), use of statins(p value=0.402), beta blockers or nitrates (p values= 1 & 0.836, respectively) and stent diameter used (p value=0.615) Conclusion This study was able to show a significant relationship between ISR and each of CHADVasc score, Age, DM, SBP during the procedure, time since the PCI was done, stent length used, pattern of the lesion and management of the lesions

scholarly journals Role of pre-procedural laboratory parameters in predicting in stent restenosis of drug eluting stents

2018 ◽  
Vol 70 ◽  
pp. S42
Author(s):  
Zeeshan Ahmed Mumtaz ◽  
Avinash Ashok Guthe ◽  
Milind Phadke ◽  
Zohaib Shaikh ◽  
Ajay Umakant Mahajan ◽  
...  
Keyword(s):  
Drug Eluting Stents ◽  
Laboratory Parameters ◽  
Stent Restenosis ◽  
Drug Eluting ◽  
In Stent Restenosis

scholarly journals TCT-705 Current treatment strategies for in-stent restenosis in the era of drug eluting stents: A Meta-analysis

2018 ◽  
Vol 72 (13) ◽  
pp. B282
Author(s):  
Haroon Kamran ◽  
Kleanthis Theodoropoulos ◽  
Carla Saladini ◽  
Jonathan Marmur ◽  
Giulio Stefanini
Keyword(s):  
Meta Analysis ◽  
Treatment Strategies ◽  
Current Treatment ◽  
Drug Eluting Stents ◽  
Stent Restenosis ◽  
Drug Eluting ◽  
In Stent Restenosis

NUMERICAL SIMULATION ON THE EFFECTS OF DRUG-ELUTING STENTS WITH DIFFERENT LINKS ON HEMODYNAMICS AND DRUG CONCENTRATION DISTRIBUTION

2013 ◽  
Vol 13 (04) ◽  
pp. 1350070 ◽  
Author(s):  
YU CHEN ◽  
WENTAO JIANG ◽  
XI CHEN ◽  
TINGHUI ZHENG ◽  
QINGYUAN WANG ◽  
...  
Keyword(s):  
Drug Concentration ◽  
Drug Distribution ◽  
Velocity Model ◽  
Drug Eluting Stents ◽  
Concentration Region ◽  
Stent Restenosis ◽  
Drug Eluting ◽  
Model C ◽  
In Stent Restenosis ◽  
Selection Of

The changes of hemodynamics and drug distribution caused by the implantation of drug-eluting stents (DES) have a significant influence on the in-stent restenosis. The present study numerically carried out a comparative study of hemodynamics and drug distribution using four different links of DES: Cordis BX velocity (Model A), Jostent flex (Model B), Sorin Carbostent (Model C), and DT-2 (Model D). The results showed that (1) low wall shear stress (WSS) distribution region spread widely in Model C (16.16%), with the least in Model B (10.35%); (2) Model C has relatively uniform drug concentration and causes of fewer low drug concentration region; and (3) Model A has the largest drug concentration, but also the most uneven distribution of drug. It was concluded that DES with circumferential links helps to improve in-stent restenosis as compared with that with longitudinal designs, and flexible links led to more uniformly and smoothly distributed blood flow than rigid links. However, the links with longitudinal designs had a better performance as drug release carrier than that with circumferential design. And if the links are too close together, the drug cannot be released effectively in the blood vessels. The current study helps to enhance our understanding of the performance of DES and provides assistance for optimal design and selection of DES.

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