Central giant cell granuloma (CGCG) in childhood: surgical treatment by maintaining the tooth germs

Central Giant Cell Granuloma (CGCG) is a nonneoplastic benign process, of unknown etiology, more common in children and young adults. When aggressive, the lesion may result in considerable bone destruction and deformation. Oral and Maxillofacial surgery strongly depends on the nature of injury and it may vary from more conservative to more aggressive approach. Case report: The aim of the present study is to report and analyze, a giant cell central lesion in a 7-year-old patient on the right side of mandible body treated by surgical enucleation, curettage, and maintenance of the tooth germs. Discussion: In less aggressive lesions, curettage followed by radiographic monitoring is the most widely suggested treatment choice. However, the “gold standard” for aggressive and deforming lesions would be en-bloc resection with a safety margin. Most revisions show recurrence rates of 15 to 20%, thus clinical monitoring is necessary at least one year after the intervention. Conclusion: After 12 months, panoramic radiograph and computed tomography indicated new bone formation and no recurrence. In addition, good healing of soft tissues and correct eruption of the teeth #42, #43 and #44 were observed.

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Central giant cell granuloma (CGCG) in childhood: surgical treatment by maintaining the tooth germs

RSBO ◽

10.21726/rsbo.v1i1.384 ◽

2017 ◽

Vol 1 (1) ◽

pp. 37

Author(s):

Rafael Correia Cavalcante ◽

Paola Fernanda Cotait de Lucas Corso ◽

Tuany Rayra Pinto Lisboa Dias ◽

Eduarda Schramm ◽

Paulo Henrique Couto de Souza ◽

...

Keyword(s):

Giant Cell ◽

Soft Tissues ◽

Maxillofacial Surgery ◽

Safety Margin ◽

Bone Destruction ◽

Unknown Etiology ◽

Giant Cell Granuloma ◽

Aggressive Approach ◽

Central Giant Cell Granuloma ◽

Tooth Germs

Introduction: Central Giant Cell Granuloma (CGCG) is a nonneoplasticbenign process, of unknown etiology, more common in children and young adults. When aggressive, the lesion may result in considerable bone destruction and deformation. Oral and Maxillofacial surgery strongly depends on the nature of injury and it may vary from more conservative to more aggressive approach. Case report: The aim of the present study is to report and analyze, a giant cellcentral lesion in a 7-year-old patient on the right side of mandible body treated by surgical enucleation, curettage, and maintenance of the tooth germs. Discussion: In less aggressive lesions, curettage followed by radiographic monitoring is the most widely suggested treatment choice. However, the “gold standard” for aggressive and deforming lesions would be en-bloc resection with a safety margin. Most revisions show recurrence rates of 15 to 20%, thus clinicalmonitoring is necessary at least one year after the intervention. Conclusion: After 12 months, panoramic radiograph and computed tomography indicated new bone formation and no recurrence. In addition, good healing of soft tissues and correct eruption of the teeth #42, #43 and #44 were observed.

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Radiological features of central giant cell granuloma: comparative study of 7 cases and literature review

Dentomaxillofacial Radiology ◽

10.1259/dmfr.20200429 ◽

2021 ◽

pp. 20200429

Author(s):

Samip Shrestha ◽

Jia Zhang ◽

Jun Yan ◽

Xiaomin Zeng ◽

Xiaoyong Peng ◽

...

Keyword(s):

Giant Cell ◽

Clinical Features ◽

Bone Destruction ◽

Cystic Degeneration ◽

Contrast Study ◽

Imaging Features ◽

Giant Cell Granuloma ◽

Central Giant Cell Granuloma ◽

Cortical Thinning ◽

Mri Features

Objective: To review and analyze the clinical and imaging features of central giant cell granuloma patients and to review the relevant literatures for the diagnosis and clinical manifestation of central giant cell granuloma. Methods: Seven cases of central giant cell granuloma were retrospectively selected for the study, all of which were confirmed by pathology and had relevant imaging investigations. All seven cases had undergone CT scan, three cases had undergone MRI scan. Detailed clinical features were compared along with the imaging findings and analysis was done on the basis of their presentation and imaging features. Results: The clinical features, radiologic features were varied according to the site of the lesion. CT features include unevenly dense expansile mass causing bone destruction and cortical thinning. While MRI features with low to iso-intensity in T1- and T2 weighted images. There may be presence of cystic degeneration, hemorrhage or hemosiderin deposits or osteoid formation, which can cause T1 and T2 signal changes. On contrast study, the lesion doesn’t enhance but periphery may enhance mildly. Conclusion: Unevenly dense expansile mass with bone destruction and cortical thinning with low to iso-intensity in T1 weighted and T2 weighted images and mildly enhance peripherally, Central giant cell granuloma should be considered.

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Central giant cell granuloma in the mandibula: clinical, radiological and histopathological study in 2 clinical cases

Bulletin of the Academy of Sciences of Moldova. Medical Sciences ◽

10.52692/1857-0011.2021.2-70.18 ◽

2021 ◽

Vol 70 (2) ◽

Author(s):

Gheorghe Tibirna ◽

◽

Silvia Railean ◽

Egor Porosencov ◽

Tatiana Porosencova ◽

...

Keyword(s):

General Population ◽

Giant Cell ◽

Biological Behavior ◽

Unknown Etiology ◽

Histopathological Study ◽

Giant Cell Granuloma ◽

Local Inflammation ◽

Central Giant Cell Granuloma ◽

Neoplastic Lesion ◽

Proliferative Lesion

Central giant cell granuloma (CGCG) is a benign and proliferative lesion of the jaw, with an unknown etiology. It is widely considered to be a neoplastic lesion. The current etiology of GCGC is still unclear, although local inflammation, bleeding, and trauma have been suggested. The biological behavior of CGCG of the jaw varies from resting to aggressive with destructive expansion. The incidence in the general population is very low, and patients are generally under 30 years of age females. In this study, we report two cases of GCGC in 8-year-old and 13 year old girls treated surgically.

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Radiological features of Central Giant Cell Granuloma: Comparative study of 7 case reports and literature review

10.21203/rs.3.rs-26352/v1 ◽

2020 ◽

Author(s):

Samip Shrestha ◽

Jia Zhang ◽

Jun Yan ◽

Xiaomin Zeng ◽

Xiaoyong Peng ◽

...

Keyword(s):

Giant Cell ◽

Clinical Features ◽

Bone Destruction ◽

Cystic Degeneration ◽

Contrast Study ◽

Imaging Features ◽

Giant Cell Granuloma ◽

Central Giant Cell Granuloma ◽

Cortical Thinning ◽

T2 Weighted Images

Abstract Background: To review and analyze the clinical and imaging features of central giant cell granuloma patients and to review the relevant literatures for the diagnosis and clinical manifestation of central giant cell granuloma.Methods: 7 cases of central giant cell granuloma were retrospectively selected for the study all of which were confirmed by pathology and had relevant imaging investigations. All 7 cases had undergone CT scan, 3 cases had undergone MRI scan. Detailed clinical features were compared along with the imaging findings and analysis was done on the basis of their presentation and imaging features.Results: The clinical features, radiologic features were varied according to the site of the lesion. CT features include unevenly dense expansile mass causing bone destruction and cortical thinning. While MRI features with low to iso-intensity in T1 weighted and T2 weighted images. There may be presence of cystic degeneration, hemorrhage or hemosiderin deposits or osteoid formation, which can cause T1 and T2 signal changes. On contrast study, the lesion doesn’t enhance but periphery may enhance mildly. Conclusion: Unevenly dense expansile mass with bone destruction and cortical thinning with low to iso-intensity in T1 weighted and T2 weighted images and mildly enhance peripherally, CGCG should be considered.

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