Central giant cell granuloma in the mandibula: clinical, radiological and histopathological study in 2 clinical cases

Central giant cell granuloma (CGCG) is a benign and proliferative lesion of the jaw, with an unknown etiology. It is widely considered to be a neoplastic lesion. The current etiology of GCGC is still unclear, although local inflammation, bleeding, and trauma have been suggested. The biological behavior of CGCG of the jaw varies from resting to aggressive with destructive expansion. The incidence in the general population is very low, and patients are generally under 30 years of age females. In this study, we report two cases of GCGC in 8-year-old and 13 year old girls treated surgically.

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Age and Expression of CD163 and Colony-Stimulating Factor 1 Receptor (CD115) Are Associated With the Biological Behavior of Central Giant Cell Granuloma

Journal of Oral and Maxillofacial Surgery ◽

10.1016/j.joms.2017.01.001 ◽

2017 ◽

Vol 75 (7) ◽

pp. 1414-1424 ◽

Cited By ~ 2

Author(s):

Adrian Kahn ◽

Gavriel Chaushu ◽

Lana Ginene ◽

Marilena Vered

Keyword(s):

Giant Cell ◽

Biological Behavior ◽

Giant Cell Granuloma ◽

Colony Stimulating Factor ◽

Central Giant Cell Granuloma ◽

Stimulating Factor

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Intralesional Steroid Treatment of Aggressive Central Giant Cell Granuloma of the Mandible

Journal of Dentistry and Oral Sciences ◽

10.37191/mapsci-2582-3736-1(2)-007 ◽

2019 ◽

Author(s):

Mohammed H. Al-Bodbaij

Keyword(s):

Giant Cell ◽

Treatment Modalities ◽

Giant Cell Granuloma ◽

Recurrence Rates ◽

Current Case ◽

Central Giant Cell Granuloma ◽

Neoplastic Lesion ◽

Intralesional Steroid ◽

Intralesional Injections ◽

Children And Young Adults

Central giant cell granuloma (CGCG) is a non-neoplastic lesion that affects children and young adults. Various treatment modalities have been suggested for CGCG. The most commonly applied is surgery with possible variable recurrence rates. Other treatment modalities such as calcitonin and intralesional steroid have been used with good results. In the current case report, a 14-year old boy presented with an aggressive CGCG of the mandible that had been treated with six weekly intralesional injections of steroids that provided very good results.

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Aggressive Central Giant Cell Granuloma: A Case Report

Journal of Islamabad Medical & Dental College ◽

10.35787/jimdc.v9i1.428 ◽

2020 ◽

Vol 9 (1) ◽

pp. 73-75

Author(s):

Jahangir Hammad ◽

Muhammad Ayoub ◽

Kashaf-ud-doja Tariq ◽

Farhat Gul Babar

Keyword(s):

Case Report ◽

Young Adult ◽

Giant Cell ◽

Biological Behavior ◽

Giant Cell Granuloma ◽

Central Giant Cell Granuloma ◽

Giant Cell Lesion ◽

Central Giant Cell Lesion ◽

Odontogenic Lesion

Central giant cell granuloma (CGCG) is a benign non odontogenic lesion of jaw that may show aggressive behavior. It is classified as aggressive and non-aggressive lesion on the basis of biological behavior and radiographic features. Central giant cell lesion is more frequent in children and young adult before the age of 30 years with female predilection, with characteristic radiological and histopathological features. Here we present a case of a 35 years old female with clinical and radiological diagnosis of central giant cell lesion in posterior mandible confirmed by histopathology. A surgical approach with regular follow up is the treatment of choice in most of the cases. Key Words: Calcitonin, Corticosteroid, Curettage, Enucleation, Giant cell lesion

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Collision Lesion of Mandible—Coexistence of Keratocystic Odontogenic Tumor with Central Giant Cell Granuloma: A Rare Case Report

The Journal of Contemporary Dental Practice ◽

10.5005/jp-journals-10024-1327 ◽

2013 ◽

Vol 14 (2) ◽

pp. 355-359 ◽

Cited By ~ 1

Author(s):

C Prashanthi ◽

Vinayak Karun ◽

Mahesh Melkundi ◽

Sanjay Nyamati ◽

Annapoorna HB

Keyword(s):

Case Report ◽

Giant Cell ◽

Rare Case ◽

Giant Cells ◽

Odontogenic Tumor ◽

Biological Behavior ◽

Keratocystic Odontogenic Tumor ◽

Giant Cell Granuloma ◽

Central Giant Cell Granuloma ◽

Rare Case Report

ABSTRACT Aim and background An odontogenic keratocyst (OKC) or keratocystic odontogenic tumor (KCOT) and giant cell granuloma (GCG) in the jaws are common lesions which have been studied extensively in detail over the years. However, a lesion showing features of both is exceptionally rare and is reported only twice in the literature till date. Case description A rare case of OKC in mandible showing foci of GCG like areas is reported in a 29 years old male patient. Conclusion It seems to be a collision lesion, though the possibility of KCOT showing a reactive response to form giant cells or it being a rare variant cannot be totally ruled out. Clinical significance This entity requires aggressive treatment since biological behavior of this unique lesion is difficult to predict unless more of such lesions are reported and followed up in future. How to cite this article Ravi SB, Prashanthi C, Karun V, Melkundi M, Nyamati S, Annapoorna HB. Collision Lesion of Mandible: Coexistence of Keratocystic Odontogenic Tumor with Central Giant Cell Granuloma: A Rare Case Report. J Contemp Dent Pract 2013;14(2):355-359.

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Central giant cell granuloma (CGCG) in childhood: surgical treatment by maintaining the tooth germs

RSBO ◽

10.21726/rsbo.v1i1.384 ◽

2017 ◽

Vol 1 (1) ◽

pp. 37

Author(s):

Rafael Correia Cavalcante ◽

Paola Fernanda Cotait de Lucas Corso ◽

Tuany Rayra Pinto Lisboa Dias ◽

Eduarda Schramm ◽

Paulo Henrique Couto de Souza ◽

...

Keyword(s):

Giant Cell ◽

Soft Tissues ◽

Maxillofacial Surgery ◽

Safety Margin ◽

Bone Destruction ◽

Unknown Etiology ◽

Giant Cell Granuloma ◽

Aggressive Approach ◽

Central Giant Cell Granuloma ◽

Tooth Germs

Introduction: Central Giant Cell Granuloma (CGCG) is a nonneoplasticbenign process, of unknown etiology, more common in children and young adults. When aggressive, the lesion may result in considerable bone destruction and deformation. Oral and Maxillofacial surgery strongly depends on the nature of injury and it may vary from more conservative to more aggressive approach. Case report: The aim of the present study is to report and analyze, a giant cellcentral lesion in a 7-year-old patient on the right side of mandible body treated by surgical enucleation, curettage, and maintenance of the tooth germs. Discussion: In less aggressive lesions, curettage followed by radiographic monitoring is the most widely suggested treatment choice. However, the “gold standard” for aggressive and deforming lesions would be en-bloc resection with a safety margin. Most revisions show recurrence rates of 15 to 20%, thus clinicalmonitoring is necessary at least one year after the intervention. Conclusion: After 12 months, panoramic radiograph and computed tomography indicated new bone formation and no recurrence. In addition, good healing of soft tissues and correct eruption of the teeth #42, #43 and #44 were observed.

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Central giant cell granuloma (CGCG) in childhood: surgical treatment by maintaining the tooth germs

RSBO ◽

10.21726/rsbo.v14i1.636 ◽

2017 ◽

Vol 14 (1) ◽

pp. 37-43

Author(s):

Rafael Correia Cavalcante ◽

Paola Fernanda Cotait de Lucas Corso ◽

Tuany Rayra Pinto Lisboa Dias ◽

Eduarda Schramm2 ◽

Paulo Henrique Couto de Souza ◽

...

Keyword(s):

Giant Cell ◽

Soft Tissues ◽

Maxillofacial Surgery ◽

Safety Margin ◽

Bone Destruction ◽

Unknown Etiology ◽

Giant Cell Granuloma ◽

Aggressive Approach ◽

Central Giant Cell Granuloma ◽

Tooth Germs

Central Giant Cell Granuloma (CGCG) is a nonneoplastic benign process, of unknown etiology, more common in children and young adults. When aggressive, the lesion may result in considerable bone destruction and deformation. Oral and Maxillofacial surgery strongly depends on the nature of injury and it may vary from more conservative to more aggressive approach. Case report: The aim of the present study is to report and analyze, a giant cell central lesion in a 7-year-old patient on the right side of mandible body treated by surgical enucleation, curettage, and maintenance of the tooth germs. Discussion: In less aggressive lesions, curettage followed by radiographic monitoring is the most widely suggested treatment choice. However, the “gold standard” for aggressive and deforming lesions would be en-bloc resection with a safety margin. Most revisions show recurrence rates of 15 to 20%, thus clinical monitoring is necessary at least one year after the intervention. Conclusion: After 12 months, panoramic radiograph and computed tomography indicated new bone formation and no recurrence. In addition, good healing of soft tissues and correct eruption of the teeth #42, #43 and #44 were observed.

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