scholarly journals Implantes dentários em pacientes usuários de bifosfonatos: o risco de osteonecrose e perda dos implantes é real? Relato de três casos clínicos Dental implants in patients under bisphosphonate therapy: is the risk of osteonecrosis of the jaw and implant loss real? Report of three clinical cases

RSBO ◽  
2018 ◽  
Vol 1 (1) ◽  
pp. 50
Author(s):  
Roberta Targa Stramandinoli-Zanicotti ◽  
Tatiana Miranda Deliberador ◽  
Bruno Candido ◽  
Marcio Vinícius Hurczulack ◽  
Juliana Lucena Schussel ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Oral Health ◽  
Dental Implants ◽  
Risk Group ◽  
Osteonecrosis Of The Jaw ◽  
Bisphosphonate Therapy ◽  
The Past ◽  
Dental Procedures ◽  
Dental Rehabilitation

Introdução: A osteonecrose induzida por medicamentos (ONIM) é uma grave complicação da terapia com drogas antirreabsortivas, como os bifosfonatos (BFs). Embora ocorra com mais frequência em pacientes oncológicos, os quais utilizam BFs endovenosos, pacientes usuários de BFs orais para tratamento de osteoporose também se encontram no grupo de risco, principalmente quando procedimentos odontológicos cirúrgicos como exodontias e implantes dentários são realizados. Objetivo: Relatar três casos de pacientes que fizeram usode BFs no passado ou ainda utilizavam a medicação durante cirurgia para instalação de implantes dentários, abordando os principais fatores de risco para o desenvolvimento da ONIM. Conclusão: O conhecimento prévio pelo implantodontista dos efeitos adversos da terapia com drogas antirreabsortivas em pacientes que necessitam de reabilitação dentária é de extrema importância no manejo desses pacientes, uma vez que elas podem prejudicar a longevidade das reabilitações com implantes e induzir à osteonecrose dos maxilares,comprometendo não somente a saúde bucal como também interferindo negativamente na qualidade de vida dos pacientes.Introduction: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a serious complication of therapies with anti-resorptive drugs, such as bisphosphonates (BFs). Although it occurs more often in oncology patients who use intravenous BFs, patients who use oral BFs for osteoporosis are also in the risk group, especially when surgical dental procedures such as dental extraction or dental implants are performed. Objective: To report three cases of patients who were submitted to BF therapy in the past or were still using the medication during dental implants surgery and developed BRONJ and lost the implants. Conclusion: It is extremely important that the dentists are aware of the adverse effects of BF therapy in patients that require dental rehabilitation for the management thereof, since they can reduce the longevity of dental implants and induce osteonecrosis of the jaw, compromising not only their oral health but also these patients’ quality of life.

Osteonecrosis of the Jaw and Oral Health–Related Quality of Life After Adjuvant Zoledronic Acid: An Adjuvant Zoledronic Acid to Reduce Recurrence Trial Subprotocol (BIG01/04)

2013 ◽  
Vol 31 (21) ◽  
pp. 2685-2691 ◽  
Author(s):  
Emma J. Rathbone ◽  
Janet E. Brown ◽  
Helen C. Marshall ◽  
Michelle Collinson ◽  
Victoria Liversedge ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Oral Health ◽  
Zoledronic Acid ◽  
Osteonecrosis Of The Jaw ◽  
Health Related Quality ◽  
Serious Adverse Events ◽  
Related Quality ◽  
Health Related

Purpose In patients with early breast cancer, adjuvant zoledronic acid (zoledronate) may reduce recurrence and improve survival. However, zoledronate is associated with the occasional development of osteonecrosis of the jaw (ONJ). We report on the frequency of ONJ and investigate oral health–related quality of life (Oral-QoL) in a large randomized trial (Adjuvant Zoledronic Acid to Reduce Recurrence [AZURE]). Patients and Methods Three thousand three hundred sixty women with stage II or III breast cancer were randomly assigned to receive standard adjuvant systemic therapy alone or with zoledronate administered at a dose of 4 mg for 19 doses over 5 years. All potential occurrences of ONJ were reported as serious adverse events and centrally reviewed. Additionally, we invited 486 study participants to complete the Oral Health Impact Profile-14 (OHIP-14) to assess Oral-QoL around the time the patients completed 5 years on study. Multivariable linear regression was used to calculate mean scores and 95% CIs in addition to identifying independent prognostic factors. Results With a median follow-up time of 73.9 months (interquartile range, 60.7 to 84.2 months), 33 possible cases of ONJ were reported, all in the zoledronate-treated patients. Twenty-six cases were confirmed as being consistent with a diagnosis of ONJ, representing a cumulative incidence of 2.1% (95% CI, 0.9% to 3.3%) in the zoledronate arm. Three hundred sixty-two patients (74%) returned the OHIP-14 questionnaire. Neither the prevalence nor severity of impacts on Oral-QoL differed significantly between zoledronate patients and control patients. Conclusion Adjuvant zoledronate used in the intensive schedule studied in the AZURE trial is associated with a low incidence of ONJ but does not seem to adversely affect Oral-QoL.

Dental implants and improvement of oral health-related quality of life

2012 ◽  
Vol 40 ◽  
pp. 65-70 ◽  
Author(s):  
Kriz Pavel ◽  
Michaela Seydlova ◽  
Tatjana Dostalova ◽  
Valenta Zdenek ◽  
Karel Chleborad ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Oral Health ◽  
Dental Implants ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related

Factors associated with the loss of dental implants and the impact on the quality of life / Fatores associados com a perda de implantes dentários e o impacto sobre a qualidade de vida

2021 ◽  
Vol 7 (7) ◽  
pp. 72691-72704
Author(s):  
Nathalia de Faria Schimunda ◽  
Tatiana Miranda Deliberador ◽  
Gabryelle Costa Da Silva ◽  
Raphaela Christine Bastos ◽  
Marcos Gabriel Garibotti Rozza ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Oral Health ◽  
Dental Implants ◽  
Open Bite ◽  
Physical Domain ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
The Impact

Introduction: Several factors can be associated with loss of dental implants and this loss can affect the quality of life. Objective: The objective of this work was to evaluate the factors involved in the loss of dental implants as well as the impact of the loss on the individual's quality of life. Methods: This study included 25 patients who reported the loss of at least one dental implant. Personal data were collected and regarding the medical and dental history. Data such as medication use, presence of systemic diseases, smoking, and consumption of alcoholic beverages were noted. In the dental history, the items relevant to this study were whether patients installed dental implants and whether or not they were lost and how long after installation. To assess the quality of life, oral health-related quality of life, quality of sleep and anxiety trait were used the WHOQoL-bref questionnaire, oral health-related quality of life questionnaire, Sleep Assessment Questionnaire (SAQ) questionnaire and the trait-state anxiety inventory (STAI-T), respectively. In addition, the presence of dental crowding, incisal spacing, and anterior open bite were evaluated. The time elapsed between installation and implant loss was counted in months. The data were submitted to statistical analysis (Spearman, Mann-Whitney, and Kruskal-Wallis correlation and Adjusted Generalized Linear Regression). Values of p 0.05 were considered significant. Results: 25 patients participated in this study. The correlation test showed a significant moderate negative correlation between the Physical Domain of the WHOQoL-bref Questionnaire and Implant Loss Time in Months (r = -0.4689 p = 0.024). Patients with schooling up to high school lost their implants more quickly compared to patients with schooling up to higher education (? = -8.48; p = 0.047). When evaluating Implant Loss Time as an independent variable, no significant results were observed. Conclusion: The early loss of dental implants affects the general quality of life of individuals in the physical domain and this event is associated with low schooling.

scholarly journals Which symptoms negatively affect the oral health–related quality of life in patients with osteonecrosis of the jaw?

2020 ◽  
Vol 130 (2) ◽  
pp. 175-180 ◽  
Author(s):  
Takumi Sato ◽  
Junya Kusumoto ◽  
Daisuke Takeda ◽  
Megumi Kishimoto ◽  
Masahiko Kashin ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Oral Health ◽  
Osteonecrosis Of The Jaw ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related

Oral health-related quality of life and dental implants — preliminary study

Open Medicine ◽  
2012 ◽  
Vol 7 (2) ◽  
pp. 209-215 ◽  
Author(s):  
Pavel Kriz ◽  
Michaela Seydlova ◽  
Tatjana Dostalova ◽  
Zdenek Valenta ◽  
Karel Chleborad ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Oral Health ◽  
Marital Status ◽  
Dental Implants ◽  
Analysis Of Covariance ◽  
Health Related Quality ◽  
Functional Scale ◽  
Related Quality ◽  
Health Related

AbstractOral health-related quality of life (OHRQoL) is multifaceted and involves many factors. One of them is the use of dental implants. It was the aim of our study to assess whether implant therapy might improve OHRQoL. We consulted patients with at least one Astra Tech implant. Each patient completed oral health questionnaires, which were then statistically evaluated using the Wilcoxon signed-ranks test and Analysis of Covariance from a functional and aesthetic point of view. Differential response on individual scales was assessed using multivariate approach. All twelve marginal Wilcoxon tests showed an overall improvement in OHQoL (α = 0.05). On the aesthetic scale, OHRQoL was found to be associated with marital status, aesthetic reasons for undergoing surgery and number of front teeth replaced by implants. On the functional scale, three covariates were statistically significantly and appeared to have affected the levels of OHRQoL. The most significant explanatory effect was observed for the number of front teeth replaced via implantation, followed by the presence of chewing problems. Marital status was also found to have significantly affected the OHRQoL functional scale. Significant implant-related improvements in both scales were observed in patients with at least one implant in the front dental area.

scholarly journals Diabetes and Oral Health: Summary of Current Scientific Evidence for Why Transdisciplinary Collaboration Is Needed

2021 ◽  
Vol 2 ◽  
Author(s):  
Wenche Sylling Borgnakke ◽  
Prakash Poudel
Keyword(s):  
Quality Of Life ◽  
Oral Health ◽  
Periodontal Diseases ◽  
Scientific Evidence ◽  
Osteonecrosis Of The Jaw ◽  
Oral Microbiome ◽  
Oral Diseases ◽  
Melanin Pigmentation ◽  
Transdisciplinary Collaboration

This Perspective provides a brief summary of the scientific evidence for the often two-way links between hyperglycemia, including manifest diabetes mellitus (DM), and oral health. It delivers in a nutshell examples of current scientific evidence for the following oral manifestations of hyperglycemia, along with any available evidence for effect in the opposite direction: periodontal diseases, caries/periapical periodontitis, tooth loss, peri-implantitis, dry mouth (xerostomia/hyposalivation), dysbiosis in the oral microbiome, candidiasis, taste disturbances, burning mouth syndrome, cancer, traumatic ulcers, infections of oral wounds, delayed wound healing, melanin pigmentation, fissured tongue, benign migratory glossitis (geographic tongue), temporomandibular disorders, and osteonecrosis of the jaw. Evidence for effects on quality of life will also be reported. This condensed overview delivers the rationale and sets the stage for the urgent need for delivery of oral and general health care in patient-centered transdisciplinary collaboration for early detection and management of both hyperglycemia and oral diseases to improve quality of life.

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