Crystallization and Preliminary X-ray Analysis of Complexes of Porcine Pancreatic Elastase with two Natural Inhibitors

Kai Hilpert; Helga Wessnera; Christa Scholz; Patrick Scheerer; Rudolf Volkmer-Engert; Norbert KrauB

doi:10.2174/0929866043406922

Crystallization and Preliminary X-ray Analysis of Complexes of Porcine Pancreatic Elastase with two Natural Inhibitors

Protein and Peptide Letters ◽

10.2174/0929866043406922 ◽

2004 ◽

Vol 11 (4) ◽

pp. 393-399 ◽

Cited By ~ 1

Author(s):

Kai Hilpert ◽

Helga Wessnera ◽

Christa Scholz ◽

Patrick Scheerer ◽

Rudolf Volkmer-Engert ◽

...

Keyword(s):

Pancreatic Elastase ◽

X Ray ◽

Porcine Pancreatic Elastase ◽

Natural Inhibitors

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Human leukocyte and porcine pancreatic elastase: x-ray crystal structures, mechanism, substrate specificity, and mechanism-based inhibitors

Biochemistry ◽

10.1021/bi00431a001 ◽

1989 ◽

Vol 28 (5) ◽

pp. 1951-1963 ◽

Cited By ~ 281

Author(s):

Wolfram Bode ◽

Edgar Meyer ◽

James C. Powers

Keyword(s):

Substrate Specificity ◽

Crystal Structures ◽

Human Leukocyte ◽

Pancreatic Elastase ◽

X Ray ◽

Porcine Pancreatic Elastase

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X-ray diffraction analysis of the inhibition of porcine pancreatic elastase by a peptidyl trifluoromethylketone

Journal of Molecular Biology ◽

10.1016/0022-2836(88)90148-9 ◽

1988 ◽

Vol 201 (2) ◽

pp. 423-428 ◽

Cited By ~ 46

Author(s):

Lori H. Takahashi ◽

R. Radhakrishnan ◽

Richard E. Rosenfield ◽

Edgar F. Meyer ◽

Diane Amy Trainor ◽

...

Keyword(s):

Diffraction Analysis ◽

X Ray Diffraction ◽

Pancreatic Elastase ◽

X Ray ◽

Porcine Pancreatic Elastase

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A Molecular Modeling Based upon an X-Ray Crystal Structure: The Enzyme-Ligand Complexes between Porcine Pancreatic Elastase and Acetyl-Alanine-Alanine(Glycine)-Alanine

Quantitative Structure-Activity Relationships ◽

10.1002/qsar.19870060203 ◽

1987 ◽

Vol 6 (2) ◽

pp. 54-56

Author(s):

Tadao Fujita

Keyword(s):

Crystal Structure ◽

Molecular Modeling ◽

Pancreatic Elastase ◽

X Ray ◽

Porcine Pancreatic Elastase

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Structural Analysis of the Active Site of Porcine Pancreatic Elastase Based on the X-ray Crystal Structures of Complexes with Trifluoroacetyl-Dipeptide-Anilide Inhibitors

Biochemistry ◽

10.1021/bi00010a008 ◽

1995 ◽

Vol 34 (10) ◽

pp. 3193-3203 ◽

Cited By ~ 21

Author(s):

Carla Mattos ◽

Debra Ann Giammona ◽

Gregory A. Petsko ◽

Dagmar Ringe

Keyword(s):

Structural Analysis ◽

Crystal Structures ◽

Active Site ◽

Pancreatic Elastase ◽

X Ray ◽

Porcine Pancreatic Elastase

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Analysis of an enzyme-substrate complex by x-ray crystallography and transferred nuclear overhauser enhancement measurements: porcine pancreatic elastase and a hexapeptide

Biochemistry ◽

10.1021/bi00402a035 ◽

1988 ◽

Vol 27 (2) ◽

pp. 725-730 ◽

Cited By ~ 34

Author(s):

Edgar F. Meyer ◽

G. Marius Clore ◽

Angela M. Gronenborn ◽

Harley A. S. Hansen

Keyword(s):

Pancreatic Elastase ◽

X Ray ◽

X Ray Crystallography ◽

Substrate Complex ◽

Nuclear Overhauser Enhancement ◽

Enzyme Substrate ◽

Porcine Pancreatic Elastase ◽

Nuclear Overhauser

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Crystallization and preliminary X-ray analysis of the complex of porcine pancreatic elastase and a hybrid squash inhibitor

Acta Crystallographica Section D Biological Crystallography ◽

10.1107/s0907444902003840 ◽

2002 ◽

Vol 58 (4) ◽

pp. 672-674 ◽

Cited By ~ 2

Author(s):

Kai Hilpert ◽

Jens Schneider-Mergener ◽

Jacqueline Aÿ

Keyword(s):

Pancreatic Elastase ◽

X Ray ◽

Porcine Pancreatic Elastase

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Design, synthesis, and kinetic evaluation of a unique class of elastase inhibitors, the peptidyl .alpha.-ketobenzoxazoles, and the x-ray crystal structure of the covalent complex between porcine pancreatic elastase and Ac-Ala-Pro-Val-2-benzoxazole

Journal of the American Chemical Society ◽

10.1021/ja00031a046 ◽

1992 ◽

Vol 114 (5) ◽

pp. 1854-1863 ◽

Cited By ~ 99

Author(s):

Philip D. Edwards ◽

Edgar F. Meyer ◽

J. Vijayalakshmi ◽

Paul A. Tuthill ◽

Donald A. Andisik ◽

...

Keyword(s):

Crystal Structure ◽

Design Synthesis ◽

Kinetic Evaluation ◽

Pancreatic Elastase ◽

X Ray ◽

Porcine Pancreatic Elastase ◽

Covalent Complex

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Effect of the 7-amino substituent on the inhibitory potency of mechanism-based isocoumarin inhibitors for porcine pancreatic and human neutrophil elastases: a 1.85-.ANG. x-ray structure of the complex between porcine pancreatic elastase and 7-[(N-tosylphenylalanyl)amino]-4-chloro-3-methoxyisocoumarin

Journal of Medicinal Chemistry ◽

10.1021/jm00084a018 ◽

1992 ◽

Vol 35 (6) ◽

pp. 1121-1129 ◽

Cited By ~ 20

Author(s):

Maria A. Hernandez ◽

James C. Powers ◽

Jan Glinski ◽

Jozef Oleksyszyn ◽

J. Vijayalakshmi ◽

...

Keyword(s):

Human Neutrophil ◽

Inhibitory Potency ◽

Pancreatic Elastase ◽

X Ray ◽

Porcine Pancreatic Elastase

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Interaction of the peptide CF3-Leu-Ala-NH-C6 H4-CF3 (TFLA) with porcine pancreatic elastase. X-ray studies at 1.8 Å

Journal of Molecular Recognition ◽

10.1002/jmr.300030104 ◽

1990 ◽

Vol 3 (1) ◽

pp. 36-44 ◽

Cited By ~ 16

Author(s):

Ines Li de la Sierra ◽

Emmanuel Papamichael ◽

Constantinos Sakarellos ◽

Jean-Luc Dimicoli ◽

Thierry Prangé

Keyword(s):

Pancreatic Elastase ◽

X Ray ◽

Porcine Pancreatic Elastase

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3TA5-03 Structure of Porcine Pancreatic Elastase in Complex with Peptidic Inhibitor Determined by High Resolution Neutron and X-ray Crystallography(The 47th Annual Meeting of the Biophysical Society of Japan)

Seibutsu Butsuri ◽

10.2142/biophys.49.s58_3 ◽

2009 ◽

Vol 49 (supplement) ◽

pp. S58

Author(s):

Taro Tamada ◽

Takayoshi Kinoshita ◽

Kazuo Kurihara ◽

Motoyasu Adachi ◽

Takashi Oohara ◽

...

Keyword(s):

High Resolution ◽

Annual Meeting ◽

Pancreatic Elastase ◽

X Ray ◽

X Ray Crystallography ◽

Biophysical Society ◽

Porcine Pancreatic Elastase

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