scholarly journals Analysis of an enzyme-substrate complex by x-ray crystallography and transferred nuclear overhauser enhancement measurements: porcine pancreatic elastase and a hexapeptide

Biochemistry ◽  
1988 ◽  
Vol 27 (2) ◽  
pp. 725-730 ◽  
Author(s):  
Edgar F. Meyer ◽  
G. Marius Clore ◽  
Angela M. Gronenborn ◽  
Harley A. S. Hansen
Keyword(s):  
Pancreatic Elastase ◽  
X Ray ◽  
X Ray Crystallography ◽  
Substrate Complex ◽  
Nuclear Overhauser Enhancement ◽  
Enzyme Substrate ◽  
Porcine Pancreatic Elastase ◽  
Nuclear Overhauser

X-ray diffraction analysis of the inhibition of porcine pancreatic elastase by a peptidyl trifluoromethylketone

1988 ◽  
Vol 201 (2) ◽  
pp. 423-428 ◽  
Author(s):  
Lori H. Takahashi ◽  
R. Radhakrishnan ◽  
Richard E. Rosenfield ◽  
Edgar F. Meyer ◽  
Diane Amy Trainor ◽  
...  
Keyword(s):  
Diffraction Analysis ◽  
X Ray Diffraction ◽  
Pancreatic Elastase ◽  
X Ray ◽  
Porcine Pancreatic Elastase

100 Years of X-ray Crystallography

2017 ◽  
Vol 100 (1) ◽  
pp. 25-44 ◽  
Author(s):  
Terence J. Kemp ◽  
Nathaniel W. Alcock
Keyword(s):  
Data Analysis ◽  
Synchrotron Radiation ◽  
Binary Systems ◽  
Molecular Structures ◽  
X Ray ◽  
X Ray Crystallography ◽  
Bonding Theory ◽  
Enzyme Substrate ◽  
Radiation Sources ◽  
Disciplinary Field

The developments in crystallography, since it was first covered in Science Progress in 1917, following the formulation of the Bragg equation, are described. The advances in instrumentation and data analysis, coupled with the application of computational methods to data analysis, have enabled the solution of molecular structures from the simplest binary systems to the most complex of biological structures. These developments are shown to have had major impacts in the development of chemical bonding theory and in offering an increasing understanding of enzyme–substrate interactions. The advent of synchrotron radiation sources has opened a new chapter in this multi-disciplinary field of science.

Confirmation of the Structure of Fibraurin as [2r-(2-α,6aα,7α,7a-Β,8aΒ,9Β,9aα,9bΒ)]- 2-(Furan-3-yl)-7-Hydroxy-6a,9b-Dimethyl-1,2,6,6a,7,7a,8a,9,9a,9b-Decahyd Ro-9,7-Epoxymethano-4h-Oxireno-[6,7]Naphtho[2,1-C]Pyran-4,11-Dione

1986 ◽  
Vol 39 (1) ◽  
pp. 177 ◽  
Author(s):  
P Dampawan ◽  
LM Engelhardt ◽  
WC Taylor ◽  
AH White ◽  
P Wiriyachitra
Keyword(s):  
Single Crystal ◽  
Structure Determination ◽  
X Ray ◽  
Nuclear Overhauser Enhancement ◽  
Relative Stereochemistry ◽  
Nuclear Overhauser

The structure of fibraurin has been confirmed as [2R-(2α,6aα,7α,7aβ,8aβ,9β,9bβ)]-2-(furan-3-yl)-7-hydroxy-6a,9b dimethyl - 1,2,6,6a,7,7a,8a,9,9a,9b-decahydro-9,7-epoxymethano-4H-oxireno- [6,7] naphtho [2,1-c]pyran-4,11-dione(2) by a single-crystal X-ray structure determination. The relative stereochemistry is supported by nuclear Overhauser enhancement results.

Crystallization and Preliminary X-ray Analysis of Complexes of Porcine Pancreatic Elastase with two Natural Inhibitors

2004 ◽  
Vol 11 (4) ◽  
pp. 393-399 ◽  
Author(s):  
Kai Hilpert ◽  
Helga Wessnera ◽  
Christa Scholz ◽  
Patrick Scheerer ◽  
Rudolf Volkmer-Engert ◽  
...  
Keyword(s):  
Pancreatic Elastase ◽  
X Ray ◽  
Porcine Pancreatic Elastase ◽  
Natural Inhibitors
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