T-Cell Antigen Receptor Assembly and Cell Surface Expression Is Not Affected by Treatment with T-Cell Antigen Receptor-Alpha Chain Transmembrane Peptide

2007 ◽  
Vol 14 (3) ◽  
pp. 299-303 ◽  
Author(s):  
Nozomu Kurosaka ◽  
Andrea Bolte ◽  
Marina Ali ◽  
Nicholas Manolios
Keyword(s):  
T Cell ◽  
Cell Surface ◽  
Antigen Receptor ◽  
Surface Expression ◽  
Cell Surface Expression ◽  
T Cell Antigen Receptor ◽  
Cell Antigen Receptor ◽  
Cell Antigen ◽  
Receptor Assembly ◽  
Receptor Alpha Chain

CD69 cell surface expression identifies developing thymocytes which audition for T cell antigen receptor-mediated positive selection

1993 ◽  
Vol 5 (9) ◽  
pp. 1139-1150 ◽  
Author(s):  
Iwao Yamashita ◽  
Taeko Nagata ◽  
Tomlo Tada ◽  
Toshinori Nakayama
Keyword(s):  
T Cell ◽  
Cell Surface ◽  
Positive Selection ◽  
Antigen Receptor ◽  
Surface Expression ◽  
Cell Surface Expression ◽  
T Cell Antigen Receptor ◽  
Cell Antigen Receptor ◽  
Cell Antigen

scholarly journals Dominant expression of a distinctive V14+ T-cell antigen receptor alpha chain in mice.

1991 ◽  
Vol 88 (17) ◽  
pp. 7518-7522 ◽  
Author(s):  
H. Koseki ◽  
H. Asano ◽  
T. Inaba ◽  
N. Miyashita ◽  
K. Moriwaki ◽  
...  
Keyword(s):  
T Cell ◽  
Antigen Receptor ◽  
T Cell Antigen Receptor ◽  
Cell Antigen Receptor ◽  
Receptor Alpha ◽  
Cell Antigen ◽  
Alpha Chain ◽  
Receptor Alpha Chain

T-Cell Antigen Receptor-alpha Chain Transmembrane Peptides: Correlation between Structure and Function

2006 ◽  
Vol 12 (3) ◽  
pp. 261-267 ◽  
Author(s):  
Marina Ali ◽  
Noeris K. Salam ◽  
Michael Amon ◽  
Veronika Bender ◽  
David E. Hibbs ◽  
...  
Keyword(s):  
T Cell ◽  
Antigen Receptor ◽  
Structure And Function ◽  
T Cell Antigen Receptor ◽  
Transmembrane Peptides ◽  
Cell Antigen Receptor ◽  
Receptor Alpha ◽  
Cell Antigen ◽  
And Function ◽  
Receptor Alpha Chain

scholarly journals Homogenous junctional sequence of the V14+ T-cell antigen receptor alpha chain expanded in unprimed mice.

1990 ◽  
Vol 87 (14) ◽  
pp. 5248-5252 ◽  
Author(s):  
H. Koseki ◽  
K. Imai ◽  
F. Nakayama ◽  
T. Sado ◽  
K. Moriwaki ◽  
...  
Keyword(s):  
T Cell ◽  
Antigen Receptor ◽  
T Cell Antigen Receptor ◽  
Cell Antigen Receptor ◽  
Receptor Alpha ◽  
Cell Antigen ◽  
Alpha Chain ◽  
Receptor Alpha Chain

scholarly journals T−B+NK+ severe combined immunodeficiency caused by complete deficiency of the CD3ζ subunit of the T-cell antigen receptor complex

Blood ◽  
2006 ◽  
Vol 109 (8) ◽  
pp. 3198-3206 ◽  
Author(s):  
Joseph L. Roberts ◽  
Jens Peter H. Lauritsen ◽  
Myriah Cooney ◽  
Roberta E. Parrott ◽  
Elisa O. Sajaroff ◽  
...  
Keyword(s):  
T Cell ◽  
Severe Combined Immunodeficiency ◽  
Antigen Receptor ◽  
Surface Expression ◽  
Cytolytic Activity ◽  
Hybridoma Cells ◽  
Combined Immunodeficiency ◽  
T Cell Antigen Receptor ◽  
Cell Antigen Receptor ◽  
Cell Antigen

Abstract CD3ζ is a subunit of the T-cell antigen receptor (TCR) complex required for its assembly and surface expression that also plays an important role in TCR-mediated signal transduction. We report here a patient with T−B+NK+ severe combined immunodeficiency (SCID) who was homozygous for a single C insertion following nucleotide 411 in exon 7 of the CD3ζ gene. The few T cells present contained no detectable CD3ζ protein, expressed low levels of cell surface CD3ε, and were nonfunctional. CD4+CD8−CD3εlow, CD4−CD8+CD3εlow, and CD4−CD8−CD3εlow cells were detected in the periphery, and the patient also exhibited an unusual population of CD56−CD16+ NK cells with diminished cytolytic activity. Additional studies demonstrated that retrovirally transduced patient mutant CD3ζ cDNA failed to rescue assembly of nascent complete TCR complexes or surface TCR expression in CD3ζ-deficient MA5.8 murine T-cell hybridoma cells. Nascent transduced mutant CD3ζ protein was also not detected in metabolically labeled MA5.8 cells, suggesting that it was unstable and rapidly degraded. Taken together, these findings provide the first demonstration that complete CD3ζ deficiency in humans can cause SCID by preventing normal TCR assembly and surface expression.

scholarly journals Sequence and expression of transcripts of the T-cell antigen receptor alpha-chain gene in a functional, antigen-specific suppressor-T-cell hybridoma.

1986 ◽  
Vol 83 (22) ◽  
pp. 8708-8712 ◽  
Author(s):  
K. Imai ◽  
M. Kanno ◽  
H. Kimoto ◽  
K. Shigemoto ◽  
S. Yamamoto ◽  
...  
Keyword(s):  
T Cell ◽  
Antigen Receptor ◽  
Chain Gene ◽  
T Cell Antigen Receptor ◽  
Cell Antigen Receptor ◽  
Suppressor T Cell ◽  
Receptor Alpha ◽  
Cell Antigen ◽  
Alpha Chain ◽  
Receptor Alpha Chain

scholarly journals CD3-zeta surface expression is required for CD4-p56lck-mediated upregulation of T cell antigen receptor-CD3 signaling in T cells.

1992 ◽  
Vol 267 (11) ◽  
pp. 7871-7879
Author(s):  
J Sancho ◽  
J.A. Ledbetter ◽  
M.S. Choi ◽  
S.B. Kanner ◽  
J.P. Deans ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Antigen Receptor ◽  
Surface Expression ◽  
T Cell Antigen Receptor ◽  
Cell Antigen Receptor ◽  
Cell Antigen

Hierarchy of T cell antigen receptor assembly

1995 ◽  
Vol 73 (6) ◽  
pp. 544-548 ◽  
Author(s):  
NICHOLAS MANOLIOS
Keyword(s):  
T Cell ◽  
Antigen Receptor ◽  
T Cell Antigen Receptor ◽  
Cell Antigen Receptor ◽  
Cell Antigen ◽  
Receptor Assembly

scholarly journals Detection of Constant Domain of Human T Cell Antigen Receptor Alpha-Chain Via Novel Monoclonal Antibody 7F18

2014 ◽  
Vol 33 (6) ◽  
pp. 386-392
Author(s):  
Brendan K. Reed ◽  
Kyoo-A Lee ◽  
Michael P. Bell ◽  
Diana Gil ◽  
Adam G. Schrum
Keyword(s):  
Monoclonal Antibody ◽  
T Cell ◽  
Antigen Receptor ◽  
T Cell Antigen Receptor ◽  
Cell Antigen Receptor ◽  
Receptor Alpha ◽  
Cell Antigen ◽  
Constant Domain ◽  
Human T Cell ◽  
Receptor Alpha Chain
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