Insight into the Medicinal Chemistry of EGFR and HER-2 Inhibitors

2014 ◽  
Vol 21 (11) ◽  
pp. 1336-1350 ◽  
Author(s):  
C. Wang ◽  
H. Gao ◽  
J. Dong ◽  
F. Wang ◽  
P. Li ◽  
...  
Keyword(s):  
Medicinal Chemistry ◽  
Her 2 ◽  
Insight Into

HuR-targeted agents: an insight into medicinal chemistry, biophysical, computational studies and pharmacological effects on cancer models

2021 ◽  
pp. 114088
Author(s):  
Giulia Assoni ◽  
Valeria La Pietra ◽  
Rosangela Digilio ◽  
Caterina Ciani ◽  
Nausicaa Valentina Licata ◽  
...  
Keyword(s):  
Medicinal Chemistry ◽  
Computational Studies ◽  
Pharmacological Effects ◽  
Targeted Agents ◽  
Cancer Models ◽  
Insight Into

Understanding Recognition and Self-assembly in Biology using the Chemist´s Toolbox. Insight into Medicinal Chemistry

2014 ◽  
Vol 14 (6) ◽  
pp. 730-739 ◽  
Author(s):  
Z.B. Quirolo ◽  
L.A. Benedini ◽  
M.A. Sequeira ◽  
M.G. Herrera ◽  
T.V. Veuthey ◽  
...  
Keyword(s):  
Self Assembly ◽  
Medicinal Chemistry ◽  
Insight Into

scholarly journals Occurrence of the d-Proline Chemotype in Enzyme Inhibitors

Symmetry ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 558 ◽  
Author(s):  
Elena Lenci ◽  
Andrea Trabocchi
Keyword(s):  
Amino Acids ◽  
Protein Interactions ◽  
Medicinal Chemistry ◽  
Enzyme Inhibitors ◽  
Proteolytic Enzymes ◽  
Building Blocks ◽  
Protein Protein Interactions ◽  
Conformationally Constrained ◽  
Biological Outcomes ◽  
Insight Into

Natural and nonnatural amino acids represent important building blocks for the development of peptidomimetic scaffolds, especially for targeting proteolytic enzymes and for addressing protein–protein interactions. Among all the different amino acids derivatives, proline is particularly relevant in chemical biology and medicinal chemistry due to its secondary structure’s inducing and stabilizing properties. Also, the pyrrolidine ring is a conformationally constrained template that can direct appendages into specific clefts of the enzyme binding site. Thus, many papers have appeared in the literature focusing on the use of proline and its derivatives as scaffolds for medicinal chemistry applications. In this review paper, an insight into the different biological outcomes of d-proline and l-proline in enzyme inhibitors is presented, especially when associated with matrix metalloprotease and metallo-β-lactamase enzymes.

Insight into the Medicinal Chemistry of the Endocannabinoid Hydrolase Inhibitors

2013 ◽  
Vol 20 (14) ◽  
pp. 1824-1846 ◽  
Author(s):  
C.N. Kapanda ◽  
J.H. Poupaert ◽  
D.M. Lambert
Keyword(s):  
Medicinal Chemistry ◽  
Insight Into

An insight into medicinal chemistry of anticancer quinoxalines

2019 ◽  
Vol 27 (1) ◽  
pp. 16-35 ◽  
Author(s):  
Tanu Kaushal ◽  
Gaurava Srivastava ◽  
Ashok Sharma ◽  
Arvind Singh Negi
Keyword(s):  
Medicinal Chemistry ◽  
Insight Into

Calibration problems in hydrogen luminosities

1966 ◽  
Vol 24 ◽  
pp. 322-330
Author(s):  
A. Beer
Keyword(s):  
Galactic Structure ◽  
B Stars ◽  
Insight Into

The investigations which I should like to summarize in this paper concern recent photo-electric luminosity determinations of O and B stars. Their final aim has been the derivation of new stellar distances, and some insight into certain patterns of galactic structure.

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