Protective Role of Natural Products in Glioblastoma Multiforme: A Focus on Nitric Oxide Pathway

2020 ◽  
Vol 28 (2) ◽  
pp. 377-400 ◽  
Author(s):  
Amir R. Afshari ◽  
Hamid Mollazadeh ◽  
Elmira Mohtashami ◽  
Arash Soltani ◽  
Mohammad Soukhtanloo ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Natural Products ◽  
Glioblastoma Multiforme ◽  
Cellular Proliferation ◽  
Protective Role ◽  
Fatal Disease ◽  
Therapeutic Modalities ◽  
No Signaling ◽  
Nitric Oxide Pathway

: In spite of therapeutic modalities such as surgical resection, chemotherapy, and radiotherapy, Glioblastoma Multiforme (GBM) remains an incurable fatal disease. This necessitates further therapeutic options that could enhance the efficacy of existing modalities. Nitric Oxide (NO), a short-lived small molecule, has been revealed to play a crucial role in the pathophysiology of GBM. Several studies have demonstrated that NO is involved in apoptosis, metastasis, cellular proliferation, angiogenesis, invasion, and many other processes implicated in GBM pathobiology. Herein, we elaborate on the role of NO as a therapeutic target in GBM and discuss some natural products affecting the NO signaling pathway.

scholarly journals Investigation of the existence and biological role of l-arginine/nitric oxide pathway in human platelets by spin-trapping/EPR studies

1991 ◽  
Vol 202 (3) ◽  
pp. 923-930 ◽  
Author(s):  
Laszlo PRONAI ◽  
Kohji ICHIMORI ◽  
Hiroyuki NOZAKI ◽  
Hiroe NAKAZAWA ◽  
Haruka OKINO ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Human Platelets ◽  
Spin Trapping ◽  
Biological Role ◽  
Nitric Oxide Pathway

scholarly journals Protective role of foliar-applied nitric oxide in Triticum aestivum under saline stress

2013 ◽  
Vol 37 ◽  
pp. 1155-1165 ◽  
Author(s):  
Farhana KAUSAR ◽  
Muhammad SHAHBAZ ◽  
Muhammad ASHRAF
Keyword(s):  
Nitric Oxide ◽  
Triticum Aestivum ◽  
Protective Role ◽  
Saline Stress

Protective role of theophylline and their interaction with nitric oxide (NO) in adjuvant-induced rheumatoid arthritis in rats

2015 ◽  
Vol 29 (2) ◽  
pp. 854-862 ◽  
Author(s):  
Rishi Pal ◽  
Manju J. Chaudhary ◽  
Prafulla C. Tiwari ◽  
Suresh Babu ◽  
K.K. Pant
Keyword(s):  
Rheumatoid Arthritis ◽  
Nitric Oxide ◽  
Protective Role

Molecular understanding of the protective role of natural products on isoproterenol-induced myocardial infarction: A review

2017 ◽  
Vol 94 ◽  
pp. 1145-1166 ◽  
Author(s):  
Zheng Wei Wong ◽  
Punniyakoti Veeraveedu Thanikachalam ◽  
Srinivasan Ramamurthy
Keyword(s):  
Myocardial Infarction ◽  
Natural Products ◽  
Protective Role

Losartan Increases No Production from the Bovine Aortic Wall That is Stimulated by Angiotensin II

2003 ◽  
Vol 1 (3) ◽  
pp. 113-117 ◽  
Author(s):  
M. Myronidou ◽  
B. Kokkas ◽  
A. Kouyoumtzis ◽  
N. Gregoriadis ◽  
A. Lourbopoulos ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Angiotensin Ii ◽  
Aortic Wall ◽  
Vascular Wall ◽  
Protective Role ◽  
Normal Function ◽  
No Production ◽  
Chemical Inactivation

In these studies we investigated if losartan, an AT1- receptor blocker has any beneficial effect on NO production from the bovine aortic preparations in vitro while under stimulation from angiotensin II. Experiments were performed on intact specimens of bovine thoracic aorta, incubated in Dulbeco's MOD medium in a metabolic shaker for 24 hours under 95 % O2 and 5 % CO2 at a temperature of 37°C. We found that angiotensin II 1nM−10 μM does not exert any statistically significant action on NO production. On the contrary, angiotensin II 10nM increases the production of NO by 58.14 % (from 12.16 + 2.9 μm/l to 19.23 + 4.2 μm/l in the presence of losartan 1nM (P<0.05). Nitric oxide levels depend on both rate production and rate catabolism or chemical inactivation. Such an equilibrium is vital for the normal function of many systems including the cardiovascular one. The above results demonstrate that the blockade of AT1-receptors favors the biosynthesis of NO and indicate the protective role of losartan on the vascular wall.

The role of the L-arginine/nitric oxide pathway for relaxation of the human lower oesophageal sphincter

1993 ◽  
Vol 149 (4) ◽  
pp. 451-459 ◽  
Author(s):  
A. TØTTRUP ◽  
L. NY ◽  
P. ALM ◽  
B. LARSSON ◽  
A. FORMAN ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Lower Oesophageal Sphincter ◽  
Nitric Oxide Pathway
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