Recent Advances in the Synthesis and Development of Curcumin, its Combinations, Formulations and Curcumin-like Compounds as Antiinfective Agents

2021 ◽  
Vol 28 ◽  
Author(s):  
Christina Kannigadu ◽  
David. D. N'Da
Keyword(s):  
Infectious Diseases ◽  
Antiviral Agents ◽  
Antibacterial Activities ◽  
Redox Active ◽  
Chron's Disease ◽  
Antiinfective Agents ◽  
Acquired Immunodeficiency ◽  
Endogenous Antioxidant ◽  
Immunodeficiency Syndrome ◽  
Tropical Climates

: Infectious diseases are caused by pathogenic microorganisms, such as bacteria, fungi, parasites and viruses. Such diseases mostly develop in tropical and sub-tropical climates and represent major health challenges. The pathogens of these diseases are able to multiply in human hosts, warranting their continual survival. Treatment is becoming extremely difficult, due to the absence of effective vaccines and the emergence of resistance by their causative pathogens to existing drugs. Several currently available drugs employ oxidative stress, resulting from the generation of reactive oxygen nitrogen species (RONS), as mechanism for exerting their pharmacological actions. RONS inhibit endogenous antioxidant enzymes, which ultimately eradicate the microbiota. Curcumin, a redox-active natural product, has for centuries been used in Asian traditional medicine for the treatment of various diseases. It is known for possessing multiple biological and pharmacological activities. Curcumin has been investigated extensively over the years for its anti-inflammatory, anticancer, antiparasitic, antiviral and antibacterial activities, and no toxicity is associated with the compound. Despite its potency and safety profile, curcumin is still in clinical trials for the treatment of diseases, such as tuberculosis, acquired immunodeficiency syndrome (AIDS), Chron’s disease, colorectal cancer and multiple myeloma, among many others, as it is yet to be qualified as a therapeutic agent. This review summarizes events over the last decade, especially, regarding the discovery of curcumin, an update of its synthesis, its pathogen specific mechanisms of action, and the pharmacological effects of its derivatives as potential antibacterial, antifungal, antiparasitic and antiviral agents for the treatment of various infectious diseases.

Significant Publications on Infectious Diseases Pharmacotherapy in 2017

2018 ◽  
Vol 32 (5) ◽  
pp. 534-545 ◽  
Author(s):  
Erik W. Skoglund ◽  
Kierra M. Dotson ◽  
Casey J. Dempsey ◽  
Christy P. Su ◽  
Farnaz Foolad ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Infectious Diseases ◽  
Acquired Immunodeficiency Syndrome ◽  
Immunodeficiency Virus ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome ◽  
Hiv Aids

Purpose: The most significant peer-reviewed articles pertaining to infectious diseases (ID) pharmacotherapy, as selected by panels of ID pharmacists, are summarized. Summary: Members of the Houston Infectious Diseases Network (HIDN) were asked to nominate peer-reviewed articles that they believed most contributed to the practice of ID pharmacotherapy in 2017, including the areas of human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS). A list of 33 articles related to general ID pharmacotherapy and 4 articles related to HIV/AIDS was compiled. A survey was distributed to members of the Society of Infectious Diseases Pharmacists (SIDP) for the purpose of selecting 10 articles believed to have made the most significant impact on general ID pharmacotherapy and the single significant publication related to HIV/AIDS. Of 524 SIDP members who responded, 221 (42%) and 95 (18%) members voted for general pharmacotherapy- and HIV/AIDS-related articles, respectively. The highest ranked articles are summarized below. Conclusion: Remaining informed on the most significant ID-related publications is a challenge when considering the large number of ID-related articles published annually. This review of significant publications in 2017 may aid in that effort.

The Relevance of Selenium to Immunity, Cancer, and Infectious/Inflammatory Diseases

2005 ◽  
Vol 66 (2) ◽  
pp. 98-102 ◽  
Author(s):  
Milly Ryan-Harshman ◽  
Walid Aldoori
Keyword(s):  
Infectious Diseases ◽  
Inflammatory Diseases ◽  
Health Benefits ◽  
Level Of Evidence ◽  
Selenium Intake ◽  
Increased Risk ◽  
Important Health ◽  
Acquired Immunodeficiency ◽  
Metabolic Activities ◽  
Immunodeficiency Syndrome

Selenium is an essential trace element involved in several key metabolic activities via selenoproteins, enzymes that are essential to protect against oxidative damage and to regulate immune function. Selenium also may have other health benefits unrelated to its enzymatic functions. It may provide important health benefits to people whose oxidative stress loads are high, such as those with inflammatory or infectious diseases like rheumatoid arthritis or human immunodeficiency virus/acquired immunodeficiency syndrome, or who are at high risk for cancers, particularly prostate cancer. Some studies have generated compelling evidence that selenium is beneficial, either alone or in conjunction with other micronutrients. Additional data from large clinical trials that provide the highest level of evidence will be key to determining the benefits accrued at various selenium intake levels. When the strength of the evidence becomes sufficient, clinical health professionals will need to use dietary and clinical assessment methods to ensure that people at increased risk for cancer or inflammatory and infectious diseases can be appropriately advised about selenium intake.

Significant Publications on Infectious Diseases Pharmacotherapy in 2016

2017 ◽  
Vol 31 (5) ◽  
pp. 469-480 ◽  
Author(s):  
Gary Fong ◽  
Erik W. Skoglund ◽  
Kady Phe ◽  
Jessica Guastadisegni ◽  
Katherine M. Shea ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Infectious Diseases ◽  
Acquired Immunodeficiency Syndrome ◽  
Clinical Pharmacists ◽  
Related Article ◽  
Starting Point ◽  
Immunodeficiency Virus ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome ◽  
Hiv Aids

Purpose: This is a summary of the most important articles on infectious diseases (ID) pharmacotherapy published in peer-reviewed literature in 2016 as selected by clinical pharmacists with ID expertise. Summary: The Houston Infectious Diseases Network (HIDN) was asked to identify articles published in peer-reviewed literature in 2016 that were believed to contribute significantly to ID pharmacotherapy, including human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS). A list of 46 articles on general ID pharmacotherapy and 8 articles on HIV/AIDS were nominated. Members of the Society of Infectious Diseases Pharmacists (SIDP) were surveyed to select 10 general ID articles believed to have made a significant impact on general ID pharmacotherapy and 1 article most significant to HIV/AIDS pharmacotherapy. Of 445 SIDP members surveyed, 212 (47.6%) and 95 (21.3%) members voted for general ID pharmacotherapy- and HIV/AIDS-related articles, respectively. The 11 highest-ranked papers (10 general ID-related articles and 1 HIV/AIDS-related article) are summarized here. Conclusion: With the large number of ID-related articles published each year, it can be challenging to stay current with the most relevant ID publications. This review of significant publications in 2016 may provide a starting point for that process.

Nasal MRSA Colonization of AIDS Patients Cared for in a Brazilian University Hospital

2001 ◽  
Vol 22 (12) ◽  
pp. 783-785 ◽  
Author(s):  
Maria Clara Padoveze ◽  
Antonia Teresinha Tresoldi ◽  
Angela vonNowakonski ◽  
Francisco Hideo Aoki ◽  
Maria Luiza Moretti Branchini
Keyword(s):  
Staphylococcus Aureus ◽  
Infectious Diseases ◽  
Acquired Immunodeficiency Syndrome ◽  
Genomic Dna ◽  
University Hospital ◽  
Nasal Colonization ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome ◽  
Dna Profiles ◽  
Mrsa Colonization

AbstractWeekly culture surveillance was conducted over a 2-year period to determine the incidence of methicillin-resistantStaphylococcus aureusnasal colonization among acquired immunodeficiency syndrome patients cared for in a day-care unit and in an infectious diseases unit. Analysis of genomic DNA profiles showed a predominant pattern in both units.

scholarly journals Significant Publications on Infectious Diseases Pharmacotherapy in 2020

2021 ◽  
pp. 089719002110404
Author(s):  
Taryn A. Eubank ◽  
Noor Zaidan ◽  
Faris S. Alnezary ◽  
Courtney Moc ◽  
Kelsey Olson ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Infectious Diseases ◽  
Acquired Immunodeficiency Syndrome ◽  
Global Pandemic ◽  
Immunodeficiency Virus ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome ◽  
Hiv Aids

Purpose. To summarize the most highly esteemed, peer-reviewed, infectious diseases (ID) pharmacotherapy articles published in 2020. Summary. Members of the Houston Infectious Diseases Network (HIDN) nominated articles that were deemed to have noteworthy contributions to ID pharmacotherapy in 2020, including those on coronavirus disease 2019 (COVID-19) and human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS). To select the most significant articles of 2020, a survey was created and distributed to members of the Society of Infectious Diseases Pharmacists (SIDP) to vote on their top 10 articles of general ID and COVID-19 pharmacotherapy and one noteworthy HIV/AIDS publication. A total of 40 articles were nominated by HIDN: 35 articles pertaining to general ID/COVID-19 pharmacotherapy and 5 articles with HIV/AIDS involvement. Of the 247 SIDP members who responded to the survey, 205 and 42 members voted for general ID/COVID-19 pharmacotherapy articles and HIV/AIDS related articles, respectively. The top publications are summarized. Conclusion. In a taxing year of a global pandemic, the abundant and rapid distribution of ID literature has made it challenging for clinicians to stay informed of significant publications across the ID spectrum. This review summarizes significant ID-related publications in 2020 with the goal of aiding clinicians in staying up to date on the most relevant publications in ID pharmacotherapy.

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