What to do with race: social factors and evaluating clinical risk in kidney transplantation

This is an Early Access article. Please select the PDF button, above, to view it. Be sure to also read the related article https://kidney360.asnjournals.org/content/early/2021/08/19/KID.0002932021

Erratum to: Prognostics of Induction Motor Shaft Based on Feature Importance and Least Square Support Vector Machine Regression

This is an erratum to International Journal of Automotive and Mechanical Engineering 2021; 18(1): 8464–8477. Please refer to the related article: https://doi.org/10.15282/ijame.18.1.2021.06.0641

The quantity of health-related article publications from universities in Saudi Arabia: A bibliometric analysis, 2008–2017

Several studies have summarized the biomedical publications in Arab countries. However, the quantity of health-related article publications from universities in recent years in Saudi Arabia is unknown. Therefore, this study aimed to perform a bibliometric analysis that showcases the quantitative health-related article publications output from universities in Saudi Arabia between 2008 and 2017. An extensive literature search was conducted using the PubMed database. The search was limited to original research articles, systematic reviews, and meta-analyses published in the English language reporting on humans from medicine and health sciences colleges by researchers affiliated with any university in Saudi Arabia between January 2008 and December 2017. A total of 3172 articles were found published between January 2008 and December 2017. The number of publication output increased significantly ( p = 0.0027) from 73 (2.3%) in 2008 to 721 (22.7%) in 2017. The highest quantity of publications came from the Riyadh region ( n = 2257), specifically King Saud University ( n = 1538). Of specific journals, the BioMed Central journals published the most articles by Saudi Arabian researchers ( n = 112). The total number of publications increased from 2% to 24.8% by region. However, approximately 80% of the papers were published in journals with an impact factor (IF) <3. Around 3.8% of the papers were published in journals that had an IF ≥6 and has increased significantly ( p = 0.030) from 0% to 1.2% in the past decade. The journal with the highest IF that published a high quantity of articles was the American Journal of Human Genetics. This study has identified a continuous significant increase in the publication of health-related articles from universities in Saudi Arabia. This study extended our knowledge of the quantity of scientific productivity in the field of medicine and health sciences over a recent decade.

Erratum to “Conserved vectors with conformable derivative for certain systems of partial differential equations with physical applications”

This erratum corrects the typing mistakes of the article “Conserved vectors with conformable derivative for certain systems of partial differential equations with physical applications,” published in Open Physics 2020;18(1):164–9, https://doi.org/10.1515/phys-2020-0127.

A comparison of large-scale science models based on textual, direct citation and hybrid relatedness

Recent large-scale bibliometric models have largely been based on direct citation, and several recent studies have explored augmenting direct citation with other citation-based or textual characteristics. In this study we compare clustering results from direct citation, extended direct citation, a textual relatedness measure, and several citation-text hybrid measures using a set of nine million documents. Three different accuracy measures are employed, one based on references in authoritative documents, one using textual relatedness, and the last using document pairs linked by grants. We find that a hybrid relatedness measure based equally on direct citation and PubMed-related article scores gives more accurate clusters (in the aggregate) than the other relatedness measures tested. We also show that the differences in cluster contents between the different models are even larger than the differences in accuracy, suggesting that the textual and citation logics are complementary. Finally, we show that for the hybrid measure based on direct citation and related article scores, the larger clusters are more oriented toward textual relatedness, while the smaller clusters are more oriented toward citation-based relatedness.

Remdesivir is least likely to be effective for safe treatment of COVID-19: A pharmacovigilant point of view

This manuscript has been published on the 29 th of May 2020 by the honorable BMJ as a rapid response to a related article. However since a DOI has not been assigned and two subsequent manuscripts have cited it, I’m preprinting a copy wishing it might reach all the interested colleagues and researchers in an easier way.

AB0093 PORPHYROMONAS GINGIVALIS - PERIODONTAL PATHOGEN WITH POTENTIAL ROLL IN RHEUMATOID ARTHRITIS

Background:In recent literature, a strong association between periodontal disease (PD) and rheumatoid arthritis (RA) has been reported. PD is a common, progressive inflammatory disease, initiated by a bacterial infection that engages the supporting structures of the teeth and leads to tooth loss. A number of common features have been identified between PD and RA.One of the most important associations is the process of citrullination, which is caused by the production of PG specific enzyme so called Porphyromonas Gingivalis Peptydil Deminase (PPAD)Objectives:The aim of the study was to show the incidence of PG in RA patients, and to compare it with patients with osteoarthritis (OA) and healthy controls (HC) and to evaluate the possible correlation between the presence of PG in patients with RA and the positivity of anti CCP and anti MCV antibodies in RA patients.Methods:The study included 30 patients with RA which fulfilled RA classification criteria from 2010, 26 patients with osteoarthritis (OA) and 24 healthy controls. All participants were genetically analyzed for the presence of PG by Chelex®100 method and polymerase chain reaction (PCR), by isolating amplified sequences of DNA in a sub gingival biofilm taken from the deep periodontal pockets. The presence of anti CCP and anti MCV autoantibodies was detected in the sera of RA patients with ELISA test.Results:The average ages of the patients in the 3 groups were as follows -51 years for RA, 52 for OA and 58 years for HC. Seventy two percent of RA patients were females.Significantly higher levels of PG were found in the periodontal pockets of.RA patients.Eighty percent of RA patients (80% or 24 RA patients) were PG positive in comparison with 35% of OA patients and 2% healthy controls.Of the PG-positive RA patients, 83% had positive and 17% had anti-CCP negative test, while of the PG-negative patients, a positive anti-CCP test was present in 33% and a negative anti-CCP test was present in 67%.Accordingly, in PG-positive RA patients positive anti-MCV test was present in 79% and negative anti-MCV test was present in 21%, and in PG-negative RA patients anti-MCV test was positive in 17% and negative in 83% patients.Table 1.Patient’s groupsRAOAHCSignificancePorphyromonas gingivalis positive24 (80%)9 (35%)7 (29%)RA→OA(p < 0.0001)RA→HC(p < 0.0001)OA→HC(p0,65)Porphyromonas gingivalis negative6 (24%)17 (65%)17(71%)Total302624Conclusion:The results of our study indicate that PG is found more frequently in periodontal pockets of patients with rheumatoid arthritis, which implies the important role of oral microbioma in RA pathogenesis, treatment and prevention.References:[1]Mikuls T. R., Thiele G. M., Deane K. D. et al. (2012). Porphyromonas gingivalis and disease-related autoantibodies in individuals at increased risk of rheumatoid arthritis. Arthritis & Rheumatism, 64(11), 3522-3530.[2]Mikuls T.R., Payne J.B., Yu F. et al. Periodontitis and Porphyromonas gingivalis in patients with rheumatoid arthritis. Arthritis Rheumatol. 2014; 66(5): 1090–1100Disclosure of Interests:Pavel Selimov: None declared, Elena Firkova: None declared, Ljubinka Damjanovska-Krstikj Grant/research support from: Roche, Speakers bureau: Pfizer, Anastas Batalov: None declared, Ana Maneva: None declared, Rositsa Karalilova: None declared, Ginka Delcheva: None declared, Katia Stefanova: None declared, Teodora Stankova: None declared

Applicability of Laser Welding in the Joining of Cast Elements of the Combustion Engine Manifold and Turbine. Part 2. Laser Welding of the Compensating Capsule with the Collector

The article presents attempts related to the laser welding of combustion engine manifold and turbine. The study discussed in the article made it possible to identify the potential and limitations connected with the application of laser welding technologies, workmanship accuracy and the positioning of elements to be welded. The study-related tests enabled the assessment of the effect of primary welding parameters on the shape of the weld both in terms of keyhole and melt-in welding processes. The first part of the research-related article discusses results concerning the laser welding of the compensating capsule with the collector