Gene Therapy to Improve High-Density Lipoprotein Metabolism and Function

2010 ◽  
Vol 16 (13) ◽  
pp. 1531-1544 ◽  
Author(s):  
Eline Van Craeyveld ◽  
Stephanie Gordts ◽  
Frank Jacobs ◽  
Bart De Geest
Keyword(s):  
Gene Therapy ◽  
High Density Lipoprotein ◽  
Lipoprotein Metabolism ◽  
Density Lipoprotein ◽  
High Density ◽  
And Function

scholarly journals Obesity-Related Changes in High-Density Lipoprotein Metabolism and Function

2020 ◽  
Vol 21 (23) ◽  
pp. 8985
Author(s):  
Julia T. Stadler ◽  
Gunther Marsche
Keyword(s):  
High Density Lipoprotein ◽  
Virgin Olive Oil ◽  
Lipoprotein Metabolism ◽  
Density Lipoprotein ◽  
High Density ◽  
Atherogenic Dyslipidemia ◽  
Hdl Function ◽  
Increased Risk ◽  
And Function ◽  
The Impact

In obese individuals, atherogenic dyslipidemia is a very common and important factor in the increased risk of cardiovascular disease. Adiposity-associated dyslipidemia is characterized by low high-density lipoprotein cholesterol (HDL-C) levels and an increase in triglyceride-rich lipoproteins. Several factors and mechanisms are involved in lowering HDL-C levels in the obese state and HDL quantity and quality is closely related to adiponectin levels and the bioactive lipid sphingosine-1-phosphate. Recent studies have shown that obesity profoundly alters HDL metabolism, resulting in altered HDL subclass distribution, composition, and function. Importantly, weight loss through gastric bypass surgery and Mediterranean diet, especially when enriched with virgin olive oil, is associated with increased HDL-C levels and significantly improved metrics of HDL function. A thorough understanding of the underlying mechanisms is crucial for a better understanding of the impact of obesity on lipoprotein metabolism and for the development of appropriate therapeutic approaches. The objective of this review article was to summarize the newly identified changes in the metabolism, composition, and function of HDL in obesity and to discuss possible pathophysiological consequences.

scholarly journals Effect of acylglyceride content on the structure and function of reconstituted high density lipoprotein particles

2001 ◽  
Vol 42 (1) ◽  
pp. 79-87 ◽  
Author(s):  
Sylvie Braschi ◽  
Cynthia R. Coffill ◽  
Tracey A-M. Neville ◽  
Darren M. Hutt ◽  
Daniel L. Sparks
Keyword(s):  
High Density Lipoprotein ◽  
Density Lipoprotein ◽  
Structure And Function ◽  
High Density ◽  
Lipoprotein Particles ◽  
And Function

scholarly journals Agonistic Human Antibodies Binding to Lecithin-Cholesterol Acyltransferase Modulate High Density Lipoprotein Metabolism

2015 ◽  
Vol 291 (6) ◽  
pp. 2799-2811 ◽  
Author(s):  
Ruwanthi N. Gunawardane ◽  
Preston Fordstrom ◽  
Derek E. Piper ◽  
Stephanie Masterman ◽  
Sophia Siu ◽  
...  
Keyword(s):  
High Density Lipoprotein ◽  
Cholesterol Acyltransferase ◽  
Lipoprotein Metabolism ◽  
Density Lipoprotein ◽  
High Density ◽  
Human Antibodies ◽  
Lecithin Cholesterol Acyltransferase

scholarly journals Role of insulin in regulation of high density lipoprotein metabolism.

1986 ◽  
Vol 28 (1) ◽  
pp. 10-18
Author(s):  
A Golay ◽  
L Zech ◽  
M Z Shi ◽  
C Y Jeng ◽  
Y A Chiou ◽  
...  
Keyword(s):  
High Density Lipoprotein ◽  
Lipoprotein Metabolism ◽  
Density Lipoprotein ◽  
High Density
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