The Role of Protein Plasticity in Computational Rationalization Studies on Regioselectivity in Testosterone Hydroxylation by Cytochrome P450 BM3 Mutants

2012 ◽  
Vol 13 (2) ◽  
pp. 155-166 ◽  
Author(s):  
Stephanie B.A. de Beer ◽  
Laura A.H. van Bergen ◽  
Karlijn Keijzer ◽  
Vanina Rea ◽  
Harini Venkataraman ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
P450 Bm3 ◽  
Cytochrome P450 Bm3 ◽  
Testosterone Hydroxylation

The role of cytochrome P450 BM3 phenylalanine-87 and threonine-268 in binding organic hydroperoxides

2016 ◽  
Vol 1860 (4) ◽  
pp. 669-677 ◽  
Author(s):  
Arthur G. Roberts ◽  
Jonathan Katayama ◽  
Rüdiger Kaspera ◽  
Kaitlyn V. Ledwitch ◽  
Isolde Le Trong ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
P450 Bm3 ◽  
Organic Hydroperoxides ◽  
Cytochrome P450 Bm3

The role of Thr268 and Phe393 in cytochrome P450 BM3

2006 ◽  
Vol 100 (5-6) ◽  
pp. 1075-1090 ◽  
Author(s):  
Jonathan P. Clark ◽  
Caroline S. Miles ◽  
Christopher G. Mowat ◽  
Malcolm D. Walkinshaw ◽  
Graeme A. Reid ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
P450 Bm3 ◽  
Cytochrome P450 Bm3

scholarly journals The role of active-site Phe87 in modulating the organic co-solvent tolerance of cytochrome P450 BM3 monooxygenase

2012 ◽  
Vol 68 (9) ◽  
pp. 1013-1017 ◽  
Author(s):  
Jochen Kuper ◽  
Kang Lan Tee ◽  
Matthias Wilmanns ◽  
Danilo Roccatano ◽  
Ulrich Schwaneberg ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Active Site ◽  
Solvent Tolerance ◽  
P450 Bm3 ◽  
Cytochrome P450 Bm3

scholarly journals Engineering the biomimetic cofactors of NMNH for cytochrome P450 BM3 based on binding conformation refinement

RSC Advances ◽  
2021 ◽  
Vol 11 (20) ◽  
pp. 12036-12042
Author(s):  
Yao Liu ◽  
Yalong Cong ◽  
Chuanxi Zhang ◽  
Bohuan Fang ◽  
Yue Pan ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Rational Design ◽  
Design Strategy ◽  
Efficient Utilization ◽  
P450 Bm3 ◽  
Binding Conformation ◽  
Cytochrome P450 Bm3

A rational design strategy was proposed to improve the efficient utilization of alternative biomimetic cofactor by P450 BM3 enzyme.

Optimisation of Cytochrome P450 BM3 Assisted by Consensus-Guided Evolution

2021 ◽  
Author(s):  
Thierry Vincent ◽  
Bruno Gaillet ◽  
Alain Garnier
Keyword(s):  
Cytochrome P450 ◽  
P450 Bm3 ◽  
Cytochrome P450 Bm3

scholarly journals Reduction of Dioxygen Catalyzed by Pyrene-Wired Heme Domain Cytochrome P450 BM3 Electrodes

2004 ◽  
Vol 126 (33) ◽  
pp. 10218-10219 ◽  
Author(s):  
Andrew K. Udit ◽  
Michael G. Hill ◽  
V. Garrett Bittner ◽  
Frances H. Arnold ◽  
Harry B. Gray
Keyword(s):  
Cytochrome P450 ◽  
P450 Bm3 ◽  
Heme Domain ◽  
Cytochrome P450 Bm3

Application of cytochrome P450 BM3 mutants as biocatalysts for the profiling of estrogen receptor binding metabolites of the mycotoxin zearalenone

Xenobiotica ◽  
2010 ◽  
Vol 41 (1) ◽  
pp. 59-70 ◽  
Author(s):  
Jelle Reinen ◽  
Livia L. Kalma ◽  
Selina Begheijn ◽  
Ferry Heus ◽  
Jan N.M. Commandeur ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Cytochrome P450 ◽  
Receptor Binding ◽  
P450 Bm3 ◽  
Estrogen Receptor Binding ◽  
Cytochrome P450 Bm3

scholarly journals Formation of Transient Oxygen Complexes of Cytochrome P450 BM3 and Nitric Oxide Synthase under High Pressure

2003 ◽  
Vol 85 (5) ◽  
pp. 3303-3309 ◽  
Author(s):  
Stéphane Marchal ◽  
Hazel Mary Girvan ◽  
Antonius C.F. Gorren ◽  
Bernd Mayer ◽  
Andrew William Munro ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
High Pressure ◽  
Cytochrome P450 ◽  
Nitric Oxide Synthase ◽  
P450 Bm3 ◽  
Cytochrome P450 Bm3 ◽  
Oxide Synthase ◽  
Oxygen Complexes
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