Hurdles with Using In Vitro Models to Predict Human Blood-brain Barrier Drug Permeability: A Special Focus on Transporters and Metabolizing Enzymes

2012 ◽  
Vol 14 (1) ◽  
pp. 120-136 ◽  
Author(s):  
Ramzi Shawahna ◽  
Xavier Decleves ◽  
Jean-Michel Scherrmann
Keyword(s):  
Blood Brain Barrier ◽  
Human Blood ◽  
In Vitro Models ◽  
Brain Barrier ◽  
Special Focus ◽  
Metabolizing Enzymes ◽  
Drug Permeability ◽  
Blood Brain

scholarly journals The SARS-CoV-2 spike protein alters barrier function in 2D static and 3D microfluidic in-vitro models of the human blood–brain barrier

2020 ◽  
Vol 146 ◽  
pp. 105131 ◽  
Author(s):  
Tetyana P. Buzhdygan ◽  
Brandon J. DeOre ◽  
Abigail Baldwin-Leclair ◽  
Trent A. Bullock ◽  
Hannah M. McGary ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Human Blood ◽  
Barrier Function ◽  
In Vitro Models ◽  
Spike Protein ◽  
Brain Barrier ◽  
Blood Brain

scholarly journals Biochemical‐ and Biophysical‐Induced Barriergenesis in the Blood–Brain Barrier: A Review of Barriergenic Factors for Use in In Vitro Models

2021 ◽  
Vol 1 (5) ◽  
pp. 2170051
Author(s):  
Christina L. Schofield ◽  
Aleixandre Rodrigo-Navarro ◽  
Matthew J. Dalby ◽  
Tom Van Agtmael ◽  
Manuel Salmeron-Sanchez
Keyword(s):  
Blood Brain Barrier ◽  
In Vitro Models ◽  
Brain Barrier ◽  
Blood Brain

Understanding the Physiology of the Blood-Brain Barrier: In Vitro Models

Physiology ◽  
1998 ◽  
Vol 13 (6) ◽  
pp. 287-293 ◽  
Author(s):  
Gerald A. Grant ◽  
N. Joan Abbott ◽  
Damir Janigro
Keyword(s):  
Central Nervous System ◽  
Tissue Culture ◽  
Nervous System ◽  
Blood Brain Barrier ◽  
In Vitro Models ◽  
Brain Barrier ◽  
Blood Brain ◽  
Brain Tissue Culture ◽  
The Brain

Endothelial cells exposed to inductive central nervous system factors differentiate into a blood-brain barrier phenotype. The blood-brain barrier frequently obstructs the passage of chemotherapeutics into the brain. Tissue culture systems have been developed to reproduce key properties of the intact blood-brain barrier and to allow for testing of mechanisms of transendothelial drug permeation.

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