Natural Products as Anticancerous Therapeutic Molecules with Special Reference to Enzymatic Targets Topoisomerase, COX, LOX and Aromatase

Author(s):  
Swati Singh ◽  
Manika Awasthi ◽  
Veda P. Pandey ◽  
Upendra N. Dwivedi
2021 ◽  
Vol 14 (02) ◽  
pp. 771-791
Author(s):  
S Rehan Ahmad

On 11th March 2020 , the WHO has declared that the Coronavirus 2 ( SARS-CoV-2) or noval coronavirus ( COVID-19) as Global Pandemic in the whole world . Yet there is no vaccine or any kind of special treatment developed even though all the nations are testing several therapeutic molecules. Different herbs that are traditional are also being used with conventional drugs since the COVID-19 outbreak and are showing promising results in for the treatment of the patients. In this paper, we will review on the use of the natural products and its findings on how it is being used for treating and preventing the infection of COVID-19.. Only those reports were included that WHO edited in the situation. The extracts of the various herbal products and the molecules that are purified exert an anti-SARS-CoV-2 action and they inhibit the virus directly since the entry of the virus by replicating them. It is even interesting to find that some of the herb related products are able to block the C-2 receptors that are protease serine TMPRRS2. These are the proteins COVID-19 virus requires to infect the human cells. Additionally it was also seen that the that he natural products we able to inhibit proteins such as papain-like or chymotrypsin-like proteases that were required in the life cycle of the SARS-CoV-2. Hence, it is concluded that the natural products can be used in combination or alone as an alternative for preventing or treating of the novel corona virus infection.


2010 ◽  
Vol 95 (9-10) ◽  
pp. 815-834 ◽  
Author(s):  
John C. Coll ◽  
Bruce F. Bowden ◽  
Gabrielle M. König ◽  
Rebecca Braslau ◽  
Ian R. Price

2020 ◽  
Vol 13 ◽  
Author(s):  
Andy Wai Kan Yeung ◽  
Andrei Mocan ◽  
Nikolay T. Tzvetkov ◽  
Karel Šmejkal ◽  
Elke H. Heiss ◽  
...  

Background: Substances present in nature have been a continuous source for the development of drugs for cardiovascular and infectious diseases, cancer, and many other diseases. As the literature concerning these natural products grows, it becomes more difficult for a reader to quickly grasp the essential facts and develop a well-informed impression of this field of research. Until now, it has also been difficult to determine which natural products and research objectives were receiving the most attention as measured by number of citations. Objective: The current study of all published articles concerned with natural products sought to identify which natural products and which research objectives are connected with the major contributors to scientific journals based on the number of relevant publications and the number of times each publication was cited elsewhere. Methods: Bibliometric data, including citation data, were extracted from the Web of Science database using the search string TS=(“natural product*)” and analyzed by the VOSviewer software. Results: The search yielded 63,194 articles, with more than half of the manuscripts published since 2012. The ratio of original articles to reviews was 5.8:1. The major contributing countries were the United States, China, Germany, Japan, and India. Articles were published mainly in journals focused on chemistry, pharmacology or biochemistry. Curcumin, resveratrol, and terpenoids were the most frequently cited natural products. Conclusion: The results of the current study provide researchers from different backgrounds and healthcare professionals with a brief overview of the major trends in natural-product research in the form of a citation-based summary of the relevant literature.


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