scholarly journals Medicinal Plants – Derived Natural Products and Phytochemical Extract as Potential Therapies for Coronavirus : Future Perspective

2021 ◽  
Vol 14 (02) ◽  
pp. 771-791
Author(s):  
S Rehan Ahmad
Keyword(s):  
Natural Products ◽  
Life Cycle ◽  
Medicinal Plants ◽  
Virus Infection ◽  
Future Perspective ◽  
Special Treatment ◽  
The Novel ◽  
Herbal Products ◽  
Global Pandemic ◽  
Therapeutic Molecules

On 11th March 2020 , the WHO has declared that the Coronavirus 2 ( SARS-CoV-2) or noval coronavirus ( COVID-19) as Global Pandemic in the whole world . Yet there is no vaccine or any kind of special treatment developed even though all the nations are testing several therapeutic molecules. Different herbs that are traditional are also being used with conventional drugs since the COVID-19 outbreak and are showing promising results in for the treatment of the patients. In this paper, we will review on the use of the natural products and its findings on how it is being used for treating and preventing the infection of COVID-19.. Only those reports were included that WHO edited in the situation. The extracts of the various herbal products and the molecules that are purified exert an anti-SARS-CoV-2 action and they inhibit the virus directly since the entry of the virus by replicating them. It is even interesting to find that some of the herb related products are able to block the C-2 receptors that are protease serine TMPRRS2. These are the proteins COVID-19 virus requires to infect the human cells. Additionally it was also seen that the that he natural products we able to inhibit proteins such as papain-like or chymotrypsin-like proteases that were required in the life cycle of the SARS-CoV-2. Hence, it is concluded that the natural products can be used in combination or alone as an alternative for preventing or treating of the novel corona virus infection.

Medicinal Plants and Natural Products, More Effective and Safer Pharmacological Treatment for the Management of Obesity

2021 ◽  
Vol 22 ◽  
Author(s):  
Harsha Negi ◽  
Meenakshi Gupta ◽  
Ramanpreet Walia ◽  
Moayad Khataibeh ◽  
Maryam Sarwat
Keyword(s):  
Natural Products ◽  
Weight Gain ◽  
Side Effects ◽  
Medicinal Plants ◽  
Mechanism Of Action ◽  
Pancreatic Lipase ◽  
Herbal Products ◽  
Prevalence Of Obesity ◽  
Herbal Plants ◽  
New Compounds

: Obesity is a major lifestyle disorder and it is correlated with several ailments. The prevalence of obesity has elevated over the years and it has become a global health problem. The drugs presently used for managing obesity have several side-effects associated with them such as diarrhoea, leakage of oily stools, etc. On the contrary, herbal plants and natural products are considered safe for use because they have lesser side effects. New compounds isolated from medicinal plants are screened and identified to determine their effectiveness and potential in preventing abnormal weight gain. In this review, the medicinal plants and natural materials were surveyed across the literature to cover those that have potential for managing and controlling weight gain, and their mechanism of action, active component, and experimental methodologies are also included. These herbal products can be developed as formulations for therapeutic use in obesity. The herbal plants mentioned in the review are classified based on their mechanism of action: inhibition of pancreatic lipase and appetite suppression activities. The ability to inhibit pancreatic lipase enzyme has been used to determine the effectiveness of herbal products for the prevention of abnormal weight gain because of its action on dietary fat and suppression of appetite. This review is an attempt to summarize the herbal plants and natural products that can be used to develop formulations effective in controlling weight gain and obesity.

scholarly journals Edible and Herbal Plants for the Prevention and Management of COVID-19

2021 ◽  
Vol 12 ◽  
Author(s):  
Sha Li ◽  
Chien-Shan Cheng ◽  
Cheng Zhang ◽  
Guo-Yi Tang ◽  
Hor-Yue Tan ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Dietary Supplements ◽  
Functional Foods ◽  
The Novel ◽  
Organ Protection ◽  
Global Pandemic ◽  
Potential Benefits ◽  
Herbal Plants ◽  
Dietary Components ◽  
Underlying Mechanisms

Background: The outbreak of the pandemic coronavirus disease 2019 (COVID-19) has now become a global pandemic spreading throughout the world. Unfortunately, due to the high infectiousness of the novel β-coronavirus, it is very likely to become an ordinary epidemic. The development of dietary supplements and functional foods might provide a strategy for the prevention and management of COVID-19.Scope and Approach: A great diversity of potential edible and medicinal plants and/or natural compounds showed potential benefits in managing SARS, which may also combat COVID-19. Moreover, many plants and compounds have currently been proposed to be protective against COVID-19. This information is based on data-driven approaches and computational chemical biology techniques. In this study, we review promising candidates of edible and medicinal plants for the prevention and management of COVID-19. We primarily focus on analyzing their underlying mechanisms. We aim to identify dietary supplements and functional foods that assist in managing this epidemic.Key findings and Conclusion: We infer that acetoside, glyasperin, isorhamnetin, and several flavonoid compounds may prevent and/or be effective in managing COVID-19 by targeting the viral infection, reducing the host cytokine storm, regulating the immune response, and providing organ protection. These bioactive dietary components (used either alone or in combination) might assist in the development of dietary supplements or functional foods for managing COVID-19.

scholarly journals Ethnomedicinal Uses of Some Common Malaysian Medicinal Plants

2021 ◽  
Author(s):  
Idris Adewale Ahmed
Keyword(s):  
Natural Products ◽  
Rural Communities ◽  
Medicinal Plants ◽  
Low Income ◽  
Sustainable Use ◽  
Indigenous Plants ◽  
Herbal Products ◽  
Development Goals ◽  
Indigenous Uses ◽  
Local Plants

Historically, natural products have always been a rich source of novel pharmacological leads, thus, making the ethnobotanical and ethnopharmacological knowledge an important and major asset of the medicinal plant-based drug discovery in providing hints for effective and safe chemotherapeutic compounds. Such knowledge, however, requires a thorough review and documentation of the ethnomedicinal and indigenous uses of local plants of every part of the world. Malaysia is a global hub for natural products which contributes to its GDP. Malaysia is also one of the 12 most diverse Megabiodiversity countries. Its rainforest is ranked 4th on the list of biodiversity hotspots in Asia after India, China, and Indonesia and is also acknowledged as the world’s oldest rainforest. Natural products are relevant to both Malaysian health care and agriculture which are parts of the national key economic areas (NKEA) under the Government’s Economic Transformation Plan as well as parts of the United Nations’ 17 Sustainable Development Goals (SDGs). Though the quality, efficacy, and safety of herbal products require global and international standardization, herbal products should be made accessible to low-income and rural communities across the globe. The proper documentation of the ethnopharmacological important plants in addition to their preservation and cultivation would enhance the sustainable use of the various indigenous plants. This work is unique in the sense that it is meant to review some of the most important high-value herbal products in Malaysia. Though it covers only a few representatives of Malaysian medicinal plants.

scholarly journals Using Micropropagation to Develop Medicinal Plants into Crops

Molecules ◽  
2021 ◽  
Vol 26 (6) ◽  
pp. 1752
Author(s):  
Rita M. Moraes ◽  
Antonio Luiz Cerdeira ◽  
Miriam V. Lourenço
Keyword(s):  
Medicinal Plants ◽  
Functional Foods ◽  
Quality And Safety ◽  
High Demand ◽  
Herbal Products ◽  
Natural Substances ◽  
Crop Development ◽  
Therapeutic Molecules ◽  
Threaten Species

Medicinal plants are still the major source of therapies for several illnesses and only part of the herbal products originates from cultivated biomass. Wild harvests represent the major supply for therapies, and such practices threaten species diversity as well as the quality and safety of the final products. This work intends to show the relevance of developing medicinal plants into crops and the use of micropropagation as technique to mass produce high-demand biomass, thus solving the supply issues of therapeutic natural substances. Herein, the review includes examples of in vitro procedures and their role in the crop development of pharmaceuticals, phytomedicinals, and functional foods. Additionally, it describes the production of high-yielding genotypes, uniform clones from highly heterozygous plants, and the identification of elite phenotypes using bioassays as a selection tool. Finally, we explore the significance of micropropagation techniques for the following: a) pharmaceutical crops for production of small therapeutic molecules (STM), b) phytomedicinal crops for production of standardized therapeutic natural products, and c) the micropropagation of plants for the production of large therapeutic molecules (LTM) including fructooligosaccharides classified as prebiotic and functional food crops.

Current Status and Future Perspective for Research on Medicinal Plants with Anticancerous Activity and Minimum Cytotoxic Value

2019 ◽  
Vol 20 (12) ◽  
pp. 1227-1243
Author(s):  
Hina Qamar ◽  
Sumbul Rehman ◽  
D.K. Chauhan
Keyword(s):  
Side Effects ◽  
Medicinal Plants ◽  
Anticancer Agents ◽  
Drug Targets ◽  
Psidium Guajava ◽  
Current Status ◽  
Future Perspective ◽  
Wide Range

Cancer is the second leading cause of morbidity and mortality worldwide. Although chemotherapy and radiotherapy enhance the survival rate of cancerous patients but they have several acute toxic effects. Therefore, there is a need to search for new anticancer agents having better efficacy and lesser side effects. In this regard, herbal treatment is found to be a safe method for treating and preventing cancer. Here, an attempt has been made to screen some less explored medicinal plants like Ammania baccifera, Asclepias curassavica, Azadarichta indica, Butea monosperma, Croton tiglium, Hedera nepalensis, Jatropha curcas, Momordica charantia, Moringa oleifera, Psidium guajava, etc. having potent anticancer activity with minimum cytotoxic value (IC50 >3μM) and lesser or negligible toxicity. They are rich in active phytochemicals with a wide range of drug targets. In this study, these medicinal plants were evaluated for dose-dependent cytotoxicological studies via in vitro MTT assay and in vivo tumor models along with some more plants which are reported to have IC50 value in the range of 0.019-0.528 mg/ml. The findings indicate that these plants inhibit tumor growth by their antiproliferative, pro-apoptotic, anti-metastatic and anti-angiogenic molecular targets. They are widely used because of their easy availability, affordable price and having no or sometimes minimal side effects. This review provides a baseline for the discovery of anticancer drugs from medicinal plants having minimum cytotoxic value with minimal side effects and establishment of their analogues for the welfare of mankind.

Synthetic and semi-synthetic drugs as promising therapeutic option for the treatment of COVID-19

2020 ◽  
Vol 20 ◽  
Author(s):  
Ekta Shirbhate ◽  
Preeti Patel ◽  
Vijay K Patel ◽  
Ravichandran Veerasamy ◽  
Prabodh C Sharma ◽  
...  
Keyword(s):  
Therapeutic Option ◽  
Antiviral Treatment ◽  
The Novel ◽  
Clinical Experiences ◽  
Synthetic Compounds ◽  
Synthetic Drugs ◽  
Global Pandemic ◽  
The World ◽  
Novel Coronavirus

: The novel coronavirus disease-19 (COVID-19), a global pandemic that emerged from Wuhan, China has today travelled all around the world, so far 216 countries or territories with 21,732,472 people infected and 770,866 deaths globally (as per WHO COVID-19 update dated August 18, 2020). Continuous efforts are being made to repurpose the existing drugs and develop vaccines for combating this infection. Despite, to date, no certified antiviral treatment or vaccine prevails. Although, few candidates have displayed their efficacy in in vitro studies and are being repurposed for COVID-19 treatment. This article summarizes synthetic and semi-synthetic compounds displaying potent activity in their clinical experiences or studies against COVID-19 and also focuses on mode of action of drugs being repositioned against COVID-19.

scholarly journals An outline of SARS-CoV-2 pathogenesis and the complement cascade of immune system

2021 ◽  
Vol 45 (1) ◽  
Author(s):  
Padmalochan Hembram
Keyword(s):  
Immune System ◽  
Dark Side ◽  
Main Body ◽  
The Novel ◽  
Transmission Chain ◽  
The World ◽  
Therapeutic Molecules ◽  
Rapid Transmission ◽  
Novel Coronavirus ◽  
Near Future

Abstract Background Coronavirus disease 19 is a viral infection caused by a novel coronavirus, SARS-CoV-2. It was first notified in Wuhan, China, is now spread into numerous part of the world. Thus, the world needs urgent support and encouragement to develop a vaccine or antiviral treatments to combat the atrocious outbreak. Main body of the abstract The origin of this virus is yet unknown; however, rapid transmission from human-to-human “Anthroponosis” has widely confirmed. The world is witnessing a continuous hike in SARS-CoV-2 infection. In light of the outbreak of coronavirus disease 19, we have aimed to highlight the basic and vital information about the novel coronavirus. We provide an overview of SARS-CoV-2 transmission, timeline and its pathophysiological properties which would be an aid for the development of therapeutic molecules and antiviral drugs. Immune system plays a crucial role in virus infection in order to control but may have dark side when becomes uncontrollable. The host and SARS-CoV-2 interaction describe how the virus exploits host machinery and how overactive host immune response can cause disease severity also addressed in this review. Short conclusion Safe and effective vaccines may be the game-changing tools, but in the near future wearing mask, washing hands at regular intervals, avoiding crowed, maintaining physical distancing and hygienic surrounding, must be good practices to reduce and break the transmission chain. Still, research is ongoing not only on how vaccines protect against disease, but also against infection and transmission.

scholarly journals The Effects of Medicinal Plants and Bioactive Natural Compounds on Homocysteine

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3081
Author(s):  
Mohammad Amin Atazadegan ◽  
Mohammad Bagherniya ◽  
Gholamreza Askari ◽  
Aida Tasbandi ◽  
Amirhossein Sahebkar
Keyword(s):  
Clinical Trials ◽  
Medicinal Plants ◽  
Vascular Endothelium ◽  
Animal Studies ◽  
Natural Compounds ◽  
Herbal Products ◽  
Mortality And Morbidity ◽  
Beneficial Effects ◽  
Serum Homocysteine ◽  
Prevention And Treatment

Background: Among non-communicable diseases, cardiovascular diseases (CVDs) are the leading cause of mortality and morbidity in global communities. By 2030, CVD-related deaths are projected to reach a global rise of 25 million. Obesity, smoking, alcohol, hyperlipidemia, hypertension, and hyperhomocysteinemia are several known risk factors for CVDs. Elevated homocysteine is tightly related to CVDs through multiple mechanisms, including inflammation of the vascular endothelium. The strategies for appropriate management of CVDs are constantly evolving; medicinal plants have received remarkable attention in recent researches, since these natural products have promising effects on the prevention and treatment of various chronic diseases. The effects of nutraceuticals and herbal products on CVD/dyslipidemia have been previously studied. However, to our knowledge, the association between herbal bioactive compounds and homocysteine has not been reviewed in details. Thus, the main objective of this study is to review the efficacy of bioactive natural compounds on homocysteine levels according to clinical trials and animal studies. Results: Based on animal studies, black and green tea, cinnamon, resveratrol, curcumin, garlic extract, ginger, and soy significantly reduced the homocysteine levels. According to the clinical trials, curcumin and resveratrol showed favorable effects on serum homocysteine. In conclusion, this review highlighted the beneficial effects of medicinal plants as natural, inexpensive, and accessible agents on homocysteine levels based on animal studies. Nevertheless, the results of the clinical trials were not uniform, suggesting that more well-designed trials are warranted.

scholarly journals Design of Consumables in a Resource-Efficient Economy—A Literature Review

2021 ◽  
Vol 13 (3) ◽  
pp. 1036
Author(s):  
Siri Willskytt
Keyword(s):  
Life Cycle ◽  
Literature Review ◽  
Product Design ◽  
Circular Economy ◽  
Design Guidelines ◽  
The Novel ◽  
Specific Design ◽  
Design Considerations ◽  
Life Cycle Perspective ◽  
General Product

Consumable products have received less attention in the circular economy (CE), particularly in regard to the design of resource-efficient products. This literature review investigates the extent to which existing design guidelines for resource-efficient products are applicable to consumables. This analysis is divided into two parts. The first investigates the extent to which general product-design guidelines (i.e., applicable to both durables and consumables) are applicable to consumables. This analysis also scrutinizes the type of recommendations presented by the ecodesign and circular product design, to investigate the novel aspects of the CE in product design. The second analysis examines the type of design considerations the literature on product-type specific design guidelines recommends for specific consumables and whether such guidelines are transferable. The analysis of general guidelines showed that, although guidelines are intended to be general and applicable to many types of products, their applicability to consumable products is limited. Less than half of their recommendations can be applied to consumables. The analysis also identified several design considerations that are transferable between product-specific design guidelines. This paper shows the importance of the life-cycle perspective in product design, to maximize the opportunities to improve consumables.

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