scholarly journals Protein-Drug Interaction Studies for Development of Drugs Against Plasmodium falciparum

2009 ◽  
Vol 10 (3) ◽  
pp. 271-278 ◽  
Author(s):  
Walter de Azevedo Jr. ◽  
Rafael Caceres ◽  
Ivani Pauli ◽  
Luis Fernando Timmers ◽  
Guy Barcellos ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Drug Interaction ◽  
Protein Drug ◽  
Interaction Studies

scholarly journals Effects of Piperaquine, Chloroquine, and Amodiaquine on Drug Uptake and of These in Combination with Dihydroartemisinin against Drug-Sensitive and -Resistant Plasmodium falciparum Strains

2007 ◽  
Vol 51 (6) ◽  
pp. 2265-2267 ◽  
Author(s):  
Quinton L. Fivelman ◽  
Ipemida S. Adagu ◽  
David C. Warhurst
Keyword(s):  
Plasmodium Falciparum ◽  
Drug Interaction ◽  
Drug Uptake ◽  
Combination Therapies ◽  
Highly Active ◽  
Interaction Studies ◽  
Long Acting ◽  
Competitive Uptake ◽  
Artemisinin Combination Therapies

ABSTRACT Piperaquine is being developed as a long-acting component in artemisinin combination therapies. It was highly active in vitro and drug interaction studies showed that dihydroartemisinin combinations with piperaquine, chloroquine, and amodiaquine were indifferent tending toward antagonism. Competitive uptake of radiolabeled chloroquine and dihydroartemisinin in combination with other antimalarials was observed.

Are Clinical Therapeutic Protein-Drug Interaction Studies Needed When Disease Modification Is Driving the Potential Interaction?

2018 ◽  
Vol 58 (10) ◽  
pp. 1371-1372
Author(s):  
Yinuo Pang ◽  
Matthew R. Rosebraugh ◽  
Kevin J. Freise ◽  
Apurvasena Parikh ◽  
Mohamed-Eslam F. Mohamed
Keyword(s):  
Drug Interaction ◽  
Potential Interaction ◽  
Therapeutic Protein ◽  
Protein Drug ◽  
Disease Modification ◽  
Interaction Studies

Drug interaction studies of esomeprazole with amoxicillin and clarithromycin

2001 ◽  
Vol 120 (5) ◽  
pp. A581-A581
Author(s):  
T ANDERSSON ◽  
L ASTRAZENECA ◽  
K ROHSS ◽  
M HASSANALIN
Keyword(s):  
Drug Interaction ◽  
Interaction Studies

Lurasidone drug-drug interaction studies: a comprehensive review

2014 ◽  
Vol 29 (3) ◽  
Author(s):  
Yu-Yuan Chiu ◽  
Larry Ereshefsky ◽  
Sheldon H. Preskorn ◽  
Nagaraju Poola ◽  
Antony Loebel
Keyword(s):  
Drug Interaction ◽  
Comprehensive Review ◽  
Interaction Studies ◽  
Drug Drug Interaction

scholarly journals Energy decomposition analysis approaches and their evaluation on prototypical protein–drug interaction patterns

2015 ◽  
Vol 44 (10) ◽  
pp. 3177-3211 ◽  
Author(s):  
Maximillian J. S. Phipps ◽  
Thomas Fox ◽  
Christofer S. Tautermann ◽  
Chris-Kriton Skylaris
Keyword(s):  
Drug Interaction ◽  
Charge Transfer ◽  
Interaction Energy ◽  
Decomposition Analysis ◽  
Energy Decomposition Analysis ◽  
Chemical Components ◽  
Protein Drug ◽  
Interaction Patterns ◽  
Energy Decomposition

The partitioning of the interaction energy into chemical components such as electrostatics, polarization, and charge transfer is possible with energy decomposition analysis approaches. We review and evaluate these for biomolecular applications.

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