Targeting the Ataxia Telangiectasia Mutated Protein in Cancer Therapy

2016 ◽  
Vol 17 (2) ◽  
pp. 139-153 ◽  
Author(s):  
Donatella Vecchio ◽  
Guido Frosina
Keyword(s):  
Cancer Therapy ◽  
Ataxia Telangiectasia ◽  
Ataxia Telangiectasia Mutated ◽  
Ataxia Telangiectasia Mutated Protein

scholarly journals Ataxia Telangiectasia Mutated Protein Kinase: A Potential Master Puppeteer of Oxidative Stress-Induced Metabolic Recycling

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Marguerite Blignaut ◽  
Sarah Harries ◽  
Amanda Lochner ◽  
Barbara Huisamen
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Protein Kinase ◽  
Ataxia Telangiectasia ◽  
Regulatory Protein ◽  
Protein Aggregates ◽  
Ataxia Telangiectasia Mutated ◽  
Damage Repair ◽  
Ataxia Telangiectasia Mutated Protein

Ataxia Telangiectasia Mutated protein kinase (ATM) has recently come to the fore as a regulatory protein fulfilling many roles in the fine balancing act of metabolic homeostasis. Best known for its role as a transducer of DNA damage repair, the activity of ATM in the cytosol is enjoying increasing attention, where it plays a central role in general cellular recycling (macroautophagy) as well as the targeted clearance (selective autophagy) of damaged mitochondria and peroxisomes in response to oxidative stress, independently of the DNA damage response. The importance of ATM activation by oxidative stress has also recently been highlighted in the clearance of protein aggregates, where the expression of a functional ATM construct that cannot be activated by oxidative stress resulted in widespread accumulation of protein aggregates. This review will discuss the role of ATM in general autophagy, mitophagy, and pexophagy as well as aggrephagy and crosstalk between oxidative stress as an activator of ATM and its potential role as a master regulator of these processes.

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