Allosteric Inhibition of G-Protein Coupled Receptor Oligomerization: Strategies and Challenges for Drug Development

2014 ◽  
Vol 14 (15) ◽  
pp. 1842-1863 ◽  
Author(s):  
Mattan Hurevich ◽  
Alaa Talhami ◽  
Deborah Shalev ◽  
Chaim Gilon
Keyword(s):  
Drug Development ◽  
G Protein ◽  
G Protein Coupled Receptor ◽  
Allosteric Inhibition ◽  
Receptor Oligomerization ◽  
G Protein Coupled

scholarly journals A Computational Investigation of the Effect of Membrane Curvature on G-Protein Coupled Receptor Oligomerization

2013 ◽  
Vol 104 (2) ◽  
pp. 114a
Author(s):  
Ernesto E. Borrero ◽  
Davide Provasi ◽  
Signe Mathiasen ◽  
Dimitrios Stamou ◽  
Marta Filizola
Keyword(s):  
G Protein ◽  
Membrane Curvature ◽  
Computational Investigation ◽  
G Protein Coupled Receptor ◽  
Receptor Oligomerization ◽  
G Protein Coupled

Identification of potential dual agonists of FXR and TGR5 using e-pharmacophore based virtual screening

2015 ◽  
Vol 11 (5) ◽  
pp. 1305-1318 ◽  
Author(s):  
Thangaraj Sindhu ◽  
Pappu Srinivasan
Keyword(s):  
Bile Acid ◽  
Virtual Screening ◽  
Drug Development ◽  
G Protein ◽  
Farnesoid X Receptor ◽  
G Protein Coupled Receptor ◽  
Treatment Of Diabetes ◽  
Bile Acid Receptors ◽  
G Protein Coupled

Farnesoid X receptor and Takeda G-protein-coupled receptor-5 are well known bile acid receptors and act as promising targets for the drug development and treatment of diabetes.

scholarly journals G-Protein Coupled Receptor Oligomerization

2002 ◽  
Vol 9 (5) ◽  
pp. 317-325
Author(s):  
Hanyaloglu A.C. ◽  
Kroeger K.M. ◽  
Eidne K.A.
Keyword(s):  
G Protein ◽  
G Protein Coupled Receptor ◽  
Receptor Oligomerization ◽  
G Protein Coupled
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