Biological Activities of Artemisinin Derivatives Beyond Malaria

2019 ◽  
Vol 19 (3) ◽  
pp. 205-222 ◽  
Author(s):  
Xiaoyan Liu ◽  
Jianguo Cao ◽  
Guozheng Huang ◽  
Qingjie Zhao ◽  
Jingshan Shen
Keyword(s):  
Combination Therapy ◽  
Sesquiterpene Lactone ◽  
Artemisia Annua ◽  
Biological Activities ◽  
Structural Characteristics ◽  
Artemisinin Derivatives ◽  
Artemisia Annua L ◽  
Antivirus Activity ◽  
Clinical Drugs

Artemisinin is isolated from Artemisia annua L. with peroxide-containing sesquiterpene lactone structure. Because of its unique structural characteristics and promising anticancer, antivirus activities, it has recently received increasing attention. The aim of this review is to summarize recent discoveries of artemisinin's novel derivatives with new pharmaceutical effects beyond malaria with a focus on its antitumor and antivirus activity, as well as potential results of combination therapy with other clinical drugs.

Nutritional Properties and Biological Activities of Artemisia annua L.

2011 ◽  
Vol 40 (2) ◽  
pp. 163-170 ◽  
Author(s):  
Ji-Hyun Ryu ◽  
Ra-Jeong Kim ◽  
Soo-Jung Lee ◽  
In-Soo Kim ◽  
Hyun-Ju Lee ◽  
...  
Keyword(s):  
Artemisia Annua ◽  
Biological Activities ◽  
Nutritional Properties ◽  
Artemisia Annua L

scholarly journals Quinic acid derivatives from Artemisia annua L. leaves; biological activities and seasonal variation

2020 ◽  
Vol 128 ◽  
pp. 200-208
Author(s):  
H.I. El-Askary ◽  
S.S. Mohamed ◽  
H.M.A. El-Gohari ◽  
S.M. Ezzat ◽  
M.R. Meselhy
Keyword(s):  
Seasonal Variation ◽  
Artemisia Annua ◽  
Biological Activities ◽  
Quinic Acid ◽  
Artemisia Annua L

Comparative phytochemical study on the phenolic compounds content of Artemisia annua L. from wild populations in Republic of Moldova

Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381
Author(s):  
CP Stefanache ◽  
OC Bujor ◽  
R Necula ◽  
V Ghendov ◽  
A Trifan ◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Artemisia Annua ◽  
Wild Populations ◽  
Phytochemical Study ◽  
Republic Of Moldova ◽  
Artemisia Annua L

Hybrids of Coumarin Derivatives as Potent and Multifunctional Bioactive Agents: A Review

2020 ◽  
Vol 16 (3) ◽  
pp. 272-306
Author(s):  
Ioannis Fotopoulos ◽  
Dimitra Hadjipavlou-Litina
Keyword(s):  
Pharmacological Activity ◽  
Biological Activities ◽  
Structural Characteristics ◽  
Pharmacokinetic Profile ◽  
Biologically Active ◽  
Hybridization Technique ◽  
Coumarin Derivatives ◽  
Hybrid Molecules ◽  
Pharmacokinetic Properties ◽  
Bioactive Agents

Background: Coumarins exhibit a plethora of biological activities, e.g. antiinflammatory and anti-tumor. Molecular hybridization technique has been implemented in the design of novel coumarin hybrids with several bioactive groups in order to obtain molecules with better pharmacological activity and improved pharmacokinetic profile. Objective: Therefore, we tried to gather as many as possible biologically active coumarin hybrids referred in the literature till now, to delineate the structural characteristics in relation to the activities and to have a survey that might help the medicinal chemists to design new coumarin hybrids with drug-likeness and varied bioactivities. Results: The biological activities of the hybrids in most of the cases were found to be different from the biological activities presented by the parent coumarins. The results showed that the hybrid molecules are more potent compared to the standard drugs used in the evaluation experiments. Conclusion: Conjugation of coumarin with varied pharmacophore groups/druglike molecules responsible for different biological activities led to many novel hybrid molecules, with a multitarget behavior and improved pharmacokinetic properties.

scholarly journals Recent Developments in Inonotus obliquus (Chaga mushroom) Polysaccharides: Isolation, Structural Characteristics, Biological Activities and Application

Polymers ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 1441
Author(s):  
Yangpeng Lu ◽  
Yanan Jia ◽  
Zihan Xue ◽  
Nannan Li ◽  
Junyu Liu ◽  
...  
Keyword(s):  
Biological Activities ◽  
Structural Characteristics ◽  
Potential Candidate ◽  
Health Food ◽  
Inonotus Obliquus ◽  
Recent Developments ◽  
Inonotus Obliquus Polysaccharide ◽  
Future Work

Inonotus obliquus (Chaga mushroom) is a kind of medicine and health food widely used by folk in China, Russia, Korea, and some occidental countries. Among the extracts from Inonotus obliquus, Inonotus obliquus polysaccharide (IOPS) is supposed to be one of the major bioactive components in Inonotus obliquus, which possesses antitumor, antioxidant, anti-virus, hypoglycemic, and hypolipidemic activities. In this review, the current advancements on extraction, purification, structural characteristics, and biological activities of IOPS were summarized. This review can provide significant insight into the IOPS bioactivities as their in vitro and in vivo data were summarized, and some possible mechanisms were listed. Furthermore, applications of IOPS were reviewed and discussed; IOPS might be a potential candidate for the treatment of cancers and type 2 diabetes. Besides, new perspectives for the future work of IOPS were also proposed.

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