Water-Mediated Green and Efficient Synthesis of Bis(Indolyl)methanes Using Ammonium Iron(II) Sulfate

2019 ◽  
Vol 17 (1) ◽  
pp. 61-67 ◽  
Author(s):  
Vikas D. Kadu ◽  
Dinesh N. Nadimetla ◽  
Mahesh G. Hublikar ◽  
Dattatraya G. Raut ◽  
Raghunath B. Bhosale
Keyword(s):  
Green Water ◽  
Efficient Synthesis ◽  
Excellent Yield ◽  
Water Solvent ◽  
Ammonium Iron

An efficient protocol for the synthesis of symmetrical 3,3’-bis(indolyl)arylmethanes catalyzed by green and easily available ammonium iron(II) sulfate (Mohr’s salt) has been developed in “green” water solvent afforded in excellent yield.

Synthesis of Trans-6-(4-Chlorobenzoyl)-7-(Aryl)-1,3-Dimethyl-6,7-Dihydrofuro[3,2-d]Pyrimidine-2,4-Diones Using Choline Hydroxide as an Efficient Catalyst in an Aqueous Medium

2017 ◽  
Vol 41 (3) ◽  
pp. 139-142 ◽  
Author(s):  
Maryam Salari ◽  
Alireza Hassanabadi ◽  
Mohammad H. Mosslemin
Keyword(s):  
Aqueous Medium ◽  
Aromatic Aldehyde ◽  
Reaction Times ◽  
Efficient Synthesis ◽  
One Pot ◽  
Efficient Catalyst ◽  
Excellent Yield ◽  
One Pot Condensation

A green and efficient synthesis of the trans-6-(4-chlorobenzoyl)-7-(aryl)-1,3-dimethyl-6,7-dihydrofuro[3,2-d]pyrimidine-2,4-diones has been achieved via a three-component, one-pot condensation of 2-[2-(4-chlorophenyl)-2-oxoethyl)]isoquinolinium bromide with 1,3-dimethylbarbituric acid and an aromatic aldehyde in the presence of catalytic amounts of choline hydroxide in water under reflux conditions. This gives trans-6-(4-chlorobenzoyl)-7-(aryl)-1,3-dimethyl-6,7-dihydrofuro[3,2-d]pyrimidine-2,4-diones in excellent yield and in short reaction times.

A Facile and Efficient Synthesis of Functionalized γ-Butyrolactones from Baylis - Hillman Adducts of Isatin

2007 ◽  
Vol 60 (4) ◽  
pp. 296 ◽  
Author(s):  
Ponnusamy Shanmugam ◽  
Vadivel Vaithiyanathan ◽  
Baby Viswambharan
Keyword(s):  
Stereoselective Synthesis ◽  
Reductive Cyclization ◽  
Efficient Synthesis ◽  
Excellent Yield ◽  
Isatin Derivatives

A facile and efficient stereoselective synthesis of functionalized substituted γ-butyrolactones in excellent yield from the Baylis–Hillman adducts of isatin derivatives by a reductive cyclization methodology is reported.

N-p-Toluenesulfinyl imidazole: A new in situ reagent for the mild and efficient synthesis of p-toluenesulfinate alkyl esters and aryl esters

Synthesis ◽  
2021 ◽  
Author(s):  
Jessica L Shaw ◽  
Brad Austermuehle ◽  
Jordan M Witte ◽  
Timothy R Dorsey ◽  
Christina Delach ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
1H Nmr ◽  
Nmr Spectra ◽  
1H Nmr Spectra ◽  
Efficient Synthesis ◽  
Alkyl Esters ◽  
Synthetic Methodology ◽  
Excellent Yield ◽  
Rapid Formation

A new synthetic methodology has been developed for the synthesis of sulfinate alkyl and aryl esters. The methodology involves the combination of <i>p</i>-toluenesulfinic acid and 1,1’-carbonyl diimidazole (CDI) to create the putative reagent sulfinyl imidazole. The process spontaneously releases carbon dioxide upon the addition of the CDI to the acid suggesting the rapid formation of the proposed reagent. Reaction of this reagent with a series of alcohols (primary, secondary, and tertiary) afforded the corresponding sulfinate alkyl esters in good to excellent yield by the addition of alcohols. It was also possible to form the related sulfinate aryl esters by treating the proposed sulfinyl imidazole with selected phenols (phenol, <i>p</i>-tert-butylphenol, and thymol). The aryl esters were formed in excellent conversion based on analysis of the 500 MHz 1H NMR spectra of the crude reaction mixtures.

An iodine(iii) mediated oxidative rearrangement of enamines: efficient synthesis of α-amino ketones

2015 ◽  
Vol 51 (75) ◽  
pp. 14203-14206 ◽  
Author(s):  
Dongari Yadagiri ◽  
Pazhamalai Anbarasan
Keyword(s):  
Efficient Synthesis ◽  
Excellent Yield ◽  
Oxidative Rearrangement

An iodine(iii) mediated chemoselective oxidative rearrangement of β,β-diarylenamines to α-amino ketones has been accomplished with excellent yield.

3,5-Bis(trifluoromethyl) Phenylammonium triflate(BFPAT) as a Novel Organocatalyst for the Efficient Synthesis of 2,3-dihydroquinazolin-4(1H)-one Derivatives

2020 ◽  
Vol 17 (1) ◽  
pp. 40-45
Author(s):  
Mandana Alipour ◽  
Zinatossadat Hossaini ◽  
Samad Khaksar ◽  
Faramarz Rostami-Charati
Keyword(s):  
Ammonium Acetate ◽  
Isatoic Anhydride ◽  
Efficient Synthesis ◽  
Melting Points ◽  
One Pot ◽  
Excellent Yield ◽  
One Pot Synthesis ◽  
New Process

Aim and Objective: A one-pot synthesis of 2,3-dihydroquinazolin-4(1H)-one derivatives by threecomponent cyclo-condensation of isatoic anhydride, aldehydes and amine or ammonium acetate has been developed using 3,5-Bis(trifluoromethyl) phenylammonium triflate (BFPAT) as a new organocatalyst. Material and method: All of the obtained products are known compounds and identified by IR, 1HNMR, 13CNMR and melting points. Results: A wide variety of structurally different aldehydes reacted easily and rapidly to result in the relating 2,3-dihydroquinazolin-4(1H)-ones in good to excellent yield. Conclusion: We have demonstrated an extremely effective and new process for synthesizing 2,3- dihydroquinazolin-4(1H)-ones employing BFPAT as a novel organocatalyst in one-pot fashion.

A Novel Chemical Synthesis >1 μm2 Reduced Graphene Oxide Sheets

2012 ◽  
Vol 1390 ◽  
Author(s):  
Rebecca Isseroff ◽  
Paul Masih Das ◽  
Andrew Chen ◽  
Alexandra Tse ◽  
Sneha Chittabathini ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Reduced Graphene Oxide ◽  
Large Scale ◽  
Efficient Synthesis ◽  
Water Solvent ◽  
Reduced Graphene ◽  
Synthesis Procedure ◽  
Cost Efficient ◽  
Graphene Oxide Sheets

ABSTRACTIf graphene is to be incorporated into transistors, solar cells, and capacitors, a large-scale synthesis of graphene must be devised. This research developed an innovative, simple, and cost-efficient synthesis procedure, dispersing graphene oxide in an ethanol-water solvent and reducing slowly with sodium borohydride (NaBH4). Reducing graphene oxide in 75:25 and 50:50 H2O:ethanol solutions with 15 mmolar NaBH4 produced numerous single-layered reduced graphene oxide sheets >1 μm2, and sometimes even >2 μm2. The quality of these sheets was confirmed by Raman spectroscopy, XRD, TGA, TEM, ED, and HRTEM.

Trimethylsilyl Chloride Catalyzed Highly Efficient Synthesis of Schiff Bases of Thiazole in Glycerol under Microwave Irradiation

2019 ◽  
Vol 4 (2) ◽  
pp. 109-112
Author(s):  
Mujahed Shaikh ◽  
Ashvini Sonone ◽  
Mazahar Farooqui ◽  
Ayesha Durrani
Keyword(s):  
Reaction Time ◽  
Microwave Irradiation ◽  
Schiff Bases ◽  
Room Temperature ◽  
Environmentally Benign ◽  
Green Solvent ◽  
Efficient Synthesis ◽  
Acidic Catalyst ◽  
Excellent Yield ◽  
Work Up

A green and environmentally benign protocol is developed for the synthesis of Schiff bases of sulphur containing compound by irradiating thiazole and pyrazole aldehyde in glycerol under microwave irradiation at 70 ºC with trimethylsilyl chloride (TMSCl) as a catalyst. The method has advantages such as excellent yield, use of green solvent, easy work-up and most important the reaction completed within 2.5 min by using TMSCl catalyst. The TMSCl is an acidic catalyst, which enhances the yield of product, reaction time (with microwave, with reflux at 75 ºC and with stirring at room temperature) which can be easily removed from reaction mask.

scholarly journals Green synthesis of trans-2-(4-chlorobenzoyl)-5-hydroxy-3-(aryl)-2,3-dihydrobenzofuran-4,7-diones

2017 ◽  
Vol 41 (5) ◽  
pp. 271-274 ◽  
Author(s):  
Maryam Salari ◽  
Alireza Hassanabadi ◽  
Mohammad H. Mosslemin
Keyword(s):  
Reaction Time ◽  
Organic Solvent ◽  
Green Synthesis ◽  
Aromatic Aldehydes ◽  
Efficient Synthesis ◽  
One Pot ◽  
Short Reaction Time ◽  
Excellent Yield ◽  
One Pot Condensation ◽  
High Yields

A green and efficient synthesis of trans-2-(4-chlorobenzoyl)-5-hydroxy-3-(aryl)-2,3-dihydrobenzofuran-4,7-diones has been achieved in excellent yield via a three-component one-pot condensation of 2-[2-(4-chlorophenyl)-2-oxoethyl)]isoquinolinium bromide with 2,5-dihydroxy-1,4-benzoquinone and aromatic aldehydes in the presence of catalytic amounts of choline hydroxide in water under reflux conditions. The salient features of this protocol are the short reaction time, the high yields and it does not involve any hazardous organic solvent.

scholarly journals A novel and expeditious synthesis of oxazolidinone drugs linezolid and eperezolid

2018 ◽  
Vol 9 (4) ◽  
pp. 353-359
Author(s):  
Ranjith Siddaraj ◽  
Shivaraja Govindaiah ◽  
Raghu Ningegowda ◽  
Nanjunda Swamy Shivananju ◽  
Babu Shubha Priya
Keyword(s):  
High Purity ◽  
Synthetic Methods ◽  
Spectroscopic Techniques ◽  
Efficient Synthesis ◽  
Reaction Conditions ◽  
New Approach ◽  
Excellent Yield ◽  
Acetyl Group

A concise and efficient synthesis of linezolid and eperezolid were accomplished through a convergent scheme utilizing diverse reaction conditions. The synthesis demonstrates utility of a new approach to facilitate the expeditious construction of 3-aryl-5-(substituted methyl)-2-oxazolidinones and easier insertion of N-acetyl group. This new approach offers the possibility of accessing related 2-oxazolidinone members easily as well as making additional analogues of Linezolid. The adopted method afforded high purity and excellent yield compared to other existing synthetic methods. The compounds were successfully characterized by known spectroscopic techniques.

Sign in / Sign up

Export Citation Format

Share Document