2-quinolone-based derivatives as antibacterial agents: A review

2021 ◽  
Vol 18 ◽  
Author(s):  
Oussama Moussaoui ◽  
Said Chakroune ◽  
Youssef Kandri Rodi ◽  
El Mestafa El Hadrami
Keyword(s):  
Organic Chemistry ◽  
Green Chemistry ◽  
Antibacterial Agents ◽  
Medicinal Chemistry ◽  
Antibacterial Activities ◽  
Microwave Assisted Synthesis ◽  
Microwave Assisted ◽  
Important Family ◽  
Reduced Toxicity ◽  
Synthetic Approaches

: The chemistry of 2-quinolones derivatives has received more attention in the field of both organic chemistry and medicinal chemistry. As several advances in the application of this important family of compounds seem too significant utility. In recent years, a variety of new, effective, and novel synthetic approaches (including green chemistry, catalyzed and microwave-assisted synthesis) have been discovered and developed for the designer of various 2-quinolone-based scaffolds, representing an area of increased interest to universities and industry, as well as, to explore their antibacterial activities and reduced toxicity than the existing ones. This review summarizes the results of the literature on the synthesis strategies of 2-quinolones derivatives and their reactivity, as well as their antibacterial evaluations against different bacteria strains.

scholarly journals Green Chemistry Approach for Efficient Synthesis of Schiff Bases of Isatin Derivatives and Evaluation of Their Antibacterial Activities

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Jnyanaranjan Panda ◽  
V. Jagannath Patro ◽  
Biswa Mohan Sahoo ◽  
Jitendriya Mishra
Keyword(s):  
Green Chemistry ◽  
Schiff Bases ◽  
Reaction Times ◽  
Antibacterial Activities ◽  
Primary Amines ◽  
Microwave Assisted Synthesis ◽  
Azomethine Group ◽  
Microwave Assisted ◽  
Isatin Derivatives

Microwave-assisted organic synthesis, a green chemistry approach, is nowadays widely used in the drug synthesis. Microwave-assisted synthesis improves both throughput and turnaround time for medicinal chemists by offering the benefits of drastically reduced reaction times, increased yields, and pure products. Schiff bases are the important class of organic compounds due to their flexibility, and structural diversities due to the presence of azomethine group which is helpful for elucidating the mechanism of transformation and rasemination reaction in biological system. This novel compound could also act as valuable ligands for the development of new chemical entities. In the present work, some Schiff bases of Isatin derivatives was synthesized using microwave heating method. Schiff base of Isatin were synthesized by condensation of the keto group of Isatin with different aromatic primary amines. They were characterized by means of spectral data and subsequently subjected to the in vitro antibacterial activities against gram positive and gram negative strains of microbes. It was observed that the compound with electron withdrawing substituents exhibited good antibacterial activities against almost all the micro organisms.

Microwave assisted synthesis of novel Pyrazole derivatives and their biological evaluation as anti-bacterial agents

2020 ◽  
Vol 23 ◽  
Author(s):  
Hadis Khodadad ◽  
Farhad Hatamjafari ◽  
Khalil Pourshamsian ◽  
Babak Sadeghi
Keyword(s):  
Antibacterial Activity ◽  
Aromatic Aldehydes ◽  
Catalytic Amount ◽  
Antibacterial Activities ◽  
Structural Features ◽  
Biological Evaluation ◽  
Aureus Strain ◽  
Microwave Assisted Synthesis ◽  
Pyrazole Derivatives ◽  
Microwave Assisted

Aim and Objective: Microwave-assisted condensation of acetophenone 1 and aromatic aldehydes 2 gave chalcone analogs 3, which were cyclized to pyrazole derivatives 6a-f via the reaction with hydrazine hydrate and oxalic acid in the presence of the catalytic amount of acetic acid in ethanol. Materials and Methods: The structural features of the synthesized compounds were characterized by melting point, FT-IR, 1H, 13C NMR and elemental analysis. Results: The antibacterial activities of the synthesized pyrazoles was evaluated against three gram-positive bacteria such as Enterococcus durans, Staphylococcus aureus, Bacillus subtilis and two gram-negative bacteria such as Escherichia coli and Salmonella typhimurium. Conclusion: All the synthesized pyrazoles showed relatively high antibacterial activity against S. aureus strain and none of them demonstrated antibacterial activity against E. coli.

Microwave-Assisted Domino Cyclization Reactions

2021 ◽  
Vol 08 ◽  
Author(s):  
Yogesh B. Wagh ◽  
Dipak S. Dalal
Keyword(s):  
Microwave Irradiation ◽  
Molecular Diversity ◽  
Medicinal Chemistry ◽  
Complex Molecule ◽  
Complex Compounds ◽  
Synthetic Chemistry ◽  
Domino Reactions ◽  
Cyclization Reactions ◽  
Microwave Assisted ◽  
Synthetic Approaches

Background: Microwave-assisted domino cyclization reactions have attracted great interest for researchers to synthesize complex compounds in shorter times with increase yields. The domino reactions were used in various synthetic approaches and many drug deliveries in medicinal chemistry with microwave assisted approach. Methods: Microwave irradiation has been applied for the various domino reactions. The research related to microwave assisted domino cyclization was reviewed and the important methodologies are collected from 2011-2021. Results: Only those methodologies that involve microwave-assisted domino cyclization reactions during synthesis in a related manner have been reviewed. Along with some recent syntheses that are microwave-assisted regarding new heterocyclic moieties are summarized. Conclusion: Microwave-assisted domino cyclization reactions can be employed to quickly explore and increase molecular diversity in synthetic chemistry. We hope that this review will be helpful to find out complex molecule synthesis by microwave-assisted domino cyclization reactions. This review aimed to explain the applications of microwaves for the domino reactions from 2011-2021. In this respect, the microwave mediated methods help researchers to make helpful studies.

scholarly journals Microwave Assisted Synthesis of Organic Compounds and Nanomaterials

2021 ◽  
Author(s):  
Anjali Jha
Keyword(s):  
Green Chemistry ◽  
Organic Synthesis ◽  
Electric Fields ◽  
Chemical Reactions ◽  
Dipole Moments ◽  
Electric Heating ◽  
Microwave Assisted Synthesis ◽  
Microwave Chemistry ◽  
Microwave Assisted ◽  
Promising Area

In the Conventional laboratory or industry heating technique involve Bunsen burner, heating mental/hot plates and electric heating ovens. To produce a variety of useful compounds for betterment of mankind, the Microwave Chemistry was introduced in year 1955 and finds a place in one of the Green chemistry method. In Microwave chemistry is the science of applying microwave radiation to chemical reactions. Microwaves act as high frequency electric fields and will generally heat any material containing mobile electric charges, such as polar molecules in a solvent or conducting ions in a solid. Polar solvents are heated as their component molecules are forced to rotate with the field and lose energy in collisions i.e. the dipole moments of molecules are important in order to proceed with the chemical reactions in this method. It can be termed as microwave-assisted organic synthesis (MAOS), Microwave-Enhanced Chemistry (MEC) or Microwave-organic Reaction Enhancement synthesis (MORE). Microwave-Assisted Syntheses is a promising area of modern Green Chemistry could be adopted to save the earth.

Microwave Assisted Synthesis of New Imines of 7-Aminocephalosporinic Acid as Potent Antibacterial Agents

2014 ◽  
Vol 1 (2) ◽  
pp. 148-154
Author(s):  
A.B. Thomas ◽  
S.P. Moharil ◽  
R.K. Nanda ◽  
S.G. Dhokrat ◽  
L.K. Kothapalli ◽  
...  
Keyword(s):  
Antibacterial Agents ◽  
Microwave Assisted Synthesis ◽  
Microwave Assisted

Microwave assisted synthesis of chalcone and its polycyclic heterocyclic analogues as promising antibacterial agents: In vitro, in silico and DFT studies

2019 ◽  
Vol 1190 ◽  
pp. 77-85 ◽  
Author(s):  
Salman A. Khan ◽  
Abdullah M. Asiri ◽  
Najat Saeed M. Al-Ghamdi ◽  
Mohammad Asad ◽  
Mohie E.M. Zayed ◽  
...  
Keyword(s):  
In Silico ◽  
Antibacterial Agents ◽  
Microwave Assisted Synthesis ◽  
Dft Studies ◽  
Microwave Assisted

scholarly journals Microwave-assisted synthesis of isoindolinones via Pd-mediated tandem coupling reactions

2018 ◽  
Vol 24 (3) ◽  
pp. 129-133
Author(s):  
Eduardo Mendoza-Pérez ◽  
Alfredo Vázquez
Keyword(s):  
Organic Chemistry ◽  
Simple Procedure ◽  
Boronic Acids ◽  
Microwave Assisted Synthesis ◽  
Coupling Reactions ◽  
Synthetic Organic Chemistry ◽  
Microwave Assisted ◽  
Tandem Process ◽  
Indispensable Tool

AbstractPalladium (Pd) coupling reactions have become an indispensable tool in modern synthetic organic chemistry. A simple procedure to obtain isoindolinones 7 bearing a quaternary C-atom, featuring a Pd-mediated tandem process, is presented. Readily available iodoamidoacrylate 3 and boronic acids 6 are used as the starting materials.

Microwave-Assisted Synthesis of Diverse Pyrrolo[3,4-c]quinoline-1,3-diones and Their Antibacterial Activities

2014 ◽  
Vol 16 (7) ◽  
pp. 333-341 ◽  
Author(s):  
Likai Xia ◽  
Akber Idhayadhulla ◽  
Yong Rok Lee ◽  
Sung Hong Kim ◽  
Young-Jung Wee
Keyword(s):  
Antibacterial Activities ◽  
Microwave Assisted Synthesis ◽  
Microwave Assisted
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