A Box-Behnken Optimized Methodology for the Quantification of Diclofenac using a Carbon Paste-Multiwalled Carbon Nanotubes Electrode

2019 ◽  
Vol 15 (3) ◽  
pp. 294-304 ◽  
Author(s):  
Miriam Franco Guzmán ◽  
Luis Humberto Mendoza Huizar ◽  
Carlos Andrés Galán Vidal ◽  
Gabriela Roa Morales ◽  
Giaan A. Álvarez Romero
Keyword(s):  
Statistical Analysis ◽  
Differential Pulse Voltammetry ◽  
Heart Diseases ◽  
Differential Pulse ◽  
Carbon Paste ◽  
Multiwalled Carbon ◽  
Box Behnken Design ◽  
Frequent Consumption ◽  
Pulse Voltammetry ◽  
High Concentrations

Background: Diclofenac is a widely used nonsteroidal anti-inflammatory drug. Recent studies have shown that frequent consumption of this drug in high concentrations can cause heart diseases, so strict control of diclofenac’s quantity in commercial drugs is necessary. This paper presents the development of an optimized voltammetric methodology for the quantification of diclofenac, which offers some advantages over other electrochemical and accepted methods. Objective: Optimize with a Box-Behnken design the differential pulse voltammetry parameters towards the quantification of diclofenac in pharmaceutical samples. Methods: Diclofenac behavior in the working electrode was evaluated by cyclic voltammetry, in order to stablish the best conditions for diclofenac’s quantification. A Box-Behnken design was then used to optimize the differential pulse voltammetry parameters and stablish the analytical behavior of the proposed methodology. Commercial tablets were prepared for analysis according to the Pharmacopeia, the DPV optimized methodology was used to quantify diclofenac in the samples, and the results were statistically compared with those obtained with the official methodology. Results: After optimization, the analytical parameters found were: correlation coefficient of 0.998, detection limit of 0.001 µM, quantification limit of 0.0033 µM and sensitivity of 0.299 µA.µM-1. The statistical analysis showed there were no significant differences between the results obtained with the proposed methodology and those obtained with the official methodology. Conclusion: The statistical analysis showed that the proposed methodology is as reliable as the official spectrophotometric one for the quantification of diclofenac in commercial drugs, with very competitive analytical parameters, and even better to others found with more complex electrodes.

Determination of chloramphenicol by differential pulse voltammetry at carbon paste electrodes – The use of sodium sulfite for removal of oxygen from electrode surface

2011 ◽  
Vol 76 (5) ◽  
pp. 383-397 ◽  
Author(s):  
Ferenc T. Pastor ◽  
Hana Dejmková ◽  
Jiří Zima ◽  
Jiří Barek
Keyword(s):  
Differential Pulse Voltammetry ◽  
Glassy Carbon ◽  
Sodium Sulfite ◽  
Differential Pulse ◽  
Optimal Conditions ◽  
Carbon Paste ◽  
Tricresyl Phosphate ◽  
Carbon Paste Electrodes ◽  
Pulse Voltammetry

The possibility of determination of chloramphenicol by differential pulse voltammetry at four different carbon paste electrodes, in the full pH range (2–12) of Britton–Robinson (BR) buffer was investigated. Electrodes were prepared by mixing spectroscopic graphite powder or glassy carbon microbeads with mineral oil (Nujol) or tricresyl phosphate. Under optimal conditions (BR buffer pH 12, the electrode prepared from glassy carbon microbeads and tricresyl phosphate), linear calibration graph was obtained only in 10–5 M chloramphenicol concentration range. Determination of lower concentrations of chloramphenicol was complicated by irreproducible peak of oxygen from the carbon paste which overlapped with peak of chloramphenicol. Addition of sodium sulfite removed the oxygen peak without influence on the peak of chloramphenicol. Under optimal conditions (electrode paste made from glassy carbon microbeads, BR buffer pH 10 and 0.5 M sodium sulfite), straight calibration line was obtained in the 10–6 and 10–5 M chloramphenicol concentration range. Limit of determination was 5 × 10–7 mol/l.

scholarly journals SENSITIVE MULTIRESIDUE QUANTIFICATION OF PROCYMIDONE AND TEBUTHIURON ON CARBON PASTE ELECTRODE BY DIFFERENTIAL-PULSE VOLTAMMETRY

2016 ◽  
Vol 2 (3) ◽  
pp. 171-189
Author(s):  
Meilene Ribeiro Fidélis ◽  
Leonardo Luiz Okumura ◽  
Ástrea Filomena de Souza Silva ◽  
Alexandre Gurgel ◽  
Adelir Aparecida Saczk
Keyword(s):  
Differential Pulse Voltammetry ◽  
Carbon Paste Electrode ◽  
Supporting Electrolyte ◽  
Differential Pulse ◽  
Carbon Paste ◽  
Intermediate Precision ◽  
Water Matrix ◽  
Quantitative Analyses ◽  
Pulse Voltammetry ◽  
Paste Electrode

  Qualitative electrochemical characterization of procymidone (PRO) and tebuthiuron (TBH) was carried out by cyclic voltammetry using a carbon paste electrode. The studies suggest that analyte mass transfer is controlled by diffusion, and that oxidation of PRO and TBH occurs by means of irreversible electronic transfer of one electron. Oxidation of PRO and TBH occurs close to +0.820 V and +1.075 V (vs. Ag|AgCl, KCl 3.0 mol L-1), respectively, in a 0.1-M KOH solution as supporting electrolyte. Quantitative analyses were carried out by differential-pulse voltammetry, a technique which is more sensitive and selective. Detection and quantification limits were determined for PRO and TBH in the absence of matrix, in a potable-water matrix, and in a nonpotable-water matrix, for which the ranges of reproducibility, intermediate precision and recovery rates were (1.01 and 4.20 %), (4.08 and 9.56 %), and (90.6 and 115 %) for PRO, and (1.59 and 3.92 %), (4.84 and 7.46 %), and (91.3 and 119 %), for TBH, respectively. The results indicate that the new method is selective, simple and cheap to simultaneously quantify PRO and TBH in water samples.

scholarly journals Simultaneous Quantification of Four Principal NSAIDs through Voltammetry and Artificial Neural Networks Using a Modified Carbon Paste Electrode in Pharmaceutical Samples

2021 ◽  
Vol 5 (1) ◽  
pp. 3
Author(s):  
Guadalupe Yoselin Aguilar-Lira ◽  
Prisciliano Hernandez ◽  
Giaan Arturo Álvarez-Romero ◽  
Juan Manuel Gutiérrez
Keyword(s):  
Differential Pulse Voltammetry ◽  
Carbon Paste Electrode ◽  
Differential Pulse ◽  
Carbon Paste ◽  
Pharmaceutical Samples ◽  
Simultaneous Quantification ◽  
Drug Concentrations ◽  
Pulse Voltammetry ◽  
Artificial Neural ◽  
Paste Electrode

This work describes the development of a novel and low-cost methodology for the simultaneous quantification of four main nonsteroidal anti-inflammatory drugs (NSAIDs) in pharmaceutical samples using differential pulse voltammetry coupled with an artificial neural network model (ANN). The working electrode used as a detector was a carbon paste electrode (CPE) modified with multi-wall carbon nanotubes (MWCNT-CPE). The specific voltammetric determination of the drugs was performed by cyclic voltammetry (CV). Some characteristic anodic peaks were found at potentials of 0.446, 0.629, 0.883 V related to paracetamol, diclofenac, and aspirin. For naproxen, two anodic peaks were found at 0.888 and 1.14 V and for ibuprofen, an anodic peak was not observed at an optimum pH of 10 in 0.1 mol L−1 Britton–Robinson buffer. Since these drug’s oxidation process turned out to be irreversible and diffusion-controlled, drug quantification was carried out by differential pulse voltammetry (DPV). The Box Behnken design technique’s optimal parameters were: step potential of 5.85 mV, the amplitude of 50 mV, period of 750 ms, and a pulse width of 50 ms. A data pretreatment was carried out using the Discrete Wavelet Transform using the db4 wavelet at the fourth decomposition level applied to the voltammetric records obtained. An ANN was built to interpret the obtained approximation coefficients of voltammograms generated at different drug concentrations to calibrate the system. The ANN model’s architecture is based on a Multilayer Perceptron Network (MLP) that employed a Bayesian regularization training algorithm. The trained MLP achieves significant R values for the test data to simultaneous quantification of the four drugs in the presence of aspirin.

DIFFERENTIAL PULSE VOLTAMMETRY FOR DETERMINATION OF PARACETAMOL AT A PUMICE MIXED CARBON PASTE ELECTRODE

2001 ◽  
Vol 34 (15) ◽  
pp. 2747-2759 ◽  
Author(s):  
Chengyin Wang ◽  
Xiaoya Hu ◽  
Zongzhou Leng ◽  
Gongjun Yang ◽  
Gendi Jin
Keyword(s):  
Differential Pulse Voltammetry ◽  
Carbon Paste Electrode ◽  
Differential Pulse ◽  
Carbon Paste ◽  
Pulse Voltammetry ◽  
Paste Electrode

A graphene/ionic liquid modified selenium-doped carbon paste electrode for determination of copper and antimony

2016 ◽  
Vol 8 (5) ◽  
pp. 1120-1126 ◽  
Author(s):  
Rong Liu ◽  
Cunxi Lei ◽  
Tongsheng Zhong ◽  
Liping Long ◽  
Zhaoyang Wu ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Differential Pulse Voltammetry ◽  
Carbon Paste Electrode ◽  
Differential Pulse ◽  
Carbon Paste ◽  
Pulse Voltammetry ◽  
Paste Electrode ◽  
Determination Of Copper

A graphene (GN) and ionic liquid (IL) modified selenium-doped carbon paste electrode (GN/IL/Se/CPE) was established to simultaneously determine trace Cu(ii) and Sb(iii) by differential pulse voltammetry (DPV).

scholarly journals Electrochemical Behavior and Voltammetric Determination of a Manganese(II) Complex at a Carbon Paste Electrode

2016 ◽  
Vol 11 ◽  
pp. ACI.S32150 ◽  
Author(s):  
Sophia Karastogianni ◽  
Stella Girousi
Keyword(s):  
Carboxylic Acid ◽  
Differential Pulse Voltammetry ◽  
Carbon Paste Electrode ◽  
Electrochemical Behavior ◽  
Differential Pulse ◽  
Carbon Paste ◽  
Oxidation Reduction ◽  
Pulse Voltammetry ◽  
Paste Electrode

Investigation of the electrochemical behavior using cyclic voltammetry and detection of [Mn2+(thiophenyl-2-carboxylic acid)2 (triethanolamine)] with adsorptive stripping differential pulse voltammetry. The electrochemical behavior of a manganese(II) complex [Mn2+(thiophenyl-2-carboxylic acid)2(triethanolamine)] (A) was investigated using cyclic and differential pulse voltammetry in an acetate buffer of pH 4.6 at a carbon paste electrode. Further, an oxidation-reduction mechanism was proposed. Meanwhile, an adsorptive stripping differential pulse voltammetric method was developed for the determination of manganese(II) complex.

scholarly journals A New Sensitive Sensor for Simultaneous Differential Pulse Voltammetric Determination of Codeine and Acetaminophen Using a Hydroquinone Derivative and Multiwall Carbon Nanotubes Carbon Paste Electrode

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Elahe Garazhian ◽  
M. Reza Shishehbore
Keyword(s):  
Carbon Nanotubes ◽  
Differential Pulse Voltammetry ◽  
Multiwall Carbon Nanotubes ◽  
Differential Pulse ◽  
Carbon Paste ◽  
Sensitive Sensor ◽  
Pulse Voltammetry ◽  
Paste Electrode ◽  
Multiwall Carbon

A new sensitive sensor was fabricated for simultaneous determination of codeine and acetaminophen based on 4-hydroxy-2-(triphenylphosphonio)phenolate (HTP) and multiwall carbon nanotubes paste electrode at trace levels. The sensitivity of codeine determination was deeply affected by spiking multiwall carbon nanotubes and a modifier in carbon paste. Electron transfer coefficient,α, catalytic electron rate constant,k, and the exchange current density,j0, for oxidation of codeine at the HTP-MWCNT-CPE were calculated using cyclic voltammetry. The calibration curve was linear over the range 0.2–844.7 μM with two linear segments, and the detection limit of 0.063 μM of codeine was obtained using differential pulse voltammetry. The modified electrode was separated codeine and acetaminophen signals by differential pulse voltammetry. The modified electrode was applied for the determination of codeine and acetaminophen in biological and pharmaceutical samples with satisfactory results.

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