Umbilical Cord is a Rich Source of Mesenchymal Stromal Cells for Cell Therapy

2016 ◽  
Vol 11 (8) ◽  
pp. 634-642 ◽  
Author(s):  
Tokiko Nagamura-Inoue ◽  
Takeo Mukai
Keyword(s):  
Cell Therapy ◽  
Umbilical Cord ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Rich Source

Minimally manipulated whole human umbilical cord is a rich source of clinical-grade human mesenchymal stromal cells expanded in human platelet lysate

Cytotherapy ◽  
2011 ◽  
Vol 13 (7) ◽  
pp. 786-801 ◽  
Author(s):  
Chiara Capelli ◽  
Elisa Gotti ◽  
Marina Morigi ◽  
Cinzia Rota ◽  
Ling Weng ◽  
...  
Keyword(s):  
Umbilical Cord ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Human Platelet ◽  
Platelet Lysate ◽  
Rich Source ◽  
Human Umbilical Cord ◽  
Clinical Grade ◽  
Human Mesenchymal Stromal Cells ◽  
Human Platelet Lysate

Immunomodulatory characterization of an umbilical cord-derived mesenchymal stromal cells (UC-MSCs)-based cell therapy

Cytotherapy ◽  
2021 ◽  
Vol 23 (5) ◽  
pp. S47
Author(s):  
M. Mebarki ◽  
C. Abadie ◽  
C. Maheux ◽  
G. Churlaud ◽  
H. Boucher ◽  
...  
Keyword(s):  
Cell Therapy ◽  
Umbilical Cord ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells

scholarly journals Establishment of a Novel Fetal Growth Restriction Model and Development of a Stem-Cell Therapy Using Umbilical Cord-Derived Mesenchymal Stromal Cells

2020 ◽  
Vol 14 ◽  
Author(s):  
Yuma Kitase ◽  
Yoshiaki Sato ◽  
Sakiko Arai ◽  
Atsuto Onoda ◽  
Kazuto Ueda ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Therapy ◽  
Umbilical Cord ◽  
Mesenchymal Stromal Cells ◽  
Fetal Growth ◽  
Stem Cell Therapy ◽  
Stromal Cells ◽  
Fetal Growth Restriction ◽  
Growth Restriction

scholarly journals Individual heterogeneity screened umbilical cord-derived mesenchymal stromal cells with high Treg promotion demonstrate improved recovery of mouse liver fibrosis

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Yuanyuan Xie ◽  
Shuo Liu ◽  
Liudi Wang ◽  
Hui Yang ◽  
Chenxu Tai ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Umbilical Cord ◽  
Mesenchymal Stromal Cells ◽  
Growth Curve ◽  
Immune Regulation ◽  
Stromal Cells ◽  
Mouse Liver ◽  
Individual Heterogeneity ◽  
Therapeutic Outcomes ◽  
Multiple Donors

Abstract Background To investigate the heterogeneities of human umbilical cord mesenchymal stromal cells (HUCMSCs) derived from different donors and their therapeutic variations when applied to mouse liver fibrosis model. Methods The characteristics of HUCMSCs derived from multiple donors were comprehensively analyzed including expressions of surface markers, viability, growth curve, karyotype analysis, tumorigenicity, differentiation potentials, and immune regulation capability. Then, the HUCMSCs with distinct immunomodulatory effects were applied to treat mouse liver fibrosis and their therapeutic effects were observed. Results The HUCMSCs derived from multiple donors kept a high consistency in surface marker expressions, viability, growth curve, and tumorigenicity in nude mice but had robust heterogeneities in differentiation potentials and immune regulations. In addition, three HUCMSC lines applied to mice liver fibrosis model had different therapeutic outcomes, in line with individual immune regulation capability. Conclusion The HUCMSCs derived from different donors have individual heterogeneity, which potentially lead to distinct therapeutic outcomes in mouse liver fibrosis, indicating we could make use of the donor-variation of MSCs to screen out guaranteed general indicators of MSCs for specific diseases in further stromal cell therapy.

Effects of hypoxia on osteogenic differentiation of mesenchymal stromal cells used as a cell therapy for avascular necrosis of the femoral head

Cytotherapy ◽  
2016 ◽  
Vol 18 (9) ◽  
pp. 1087-1099 ◽  
Author(s):  
Gabriela Ciapetti ◽  
Donatella Granchi ◽  
Caterina Fotia ◽  
Lucia Savarino ◽  
Dante Dallari ◽  
...  
Keyword(s):  
Femoral Head ◽  
Cell Therapy ◽  
Osteogenic Differentiation ◽  
Avascular Necrosis ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
A Cell

Derivation of Mesenchymal Stromal Cells from Ovine Umbilical Cord Wharton's Jelly

2021 ◽  
Vol 1 (1) ◽  
Author(s):  
Irene Carreras‐Sánchez ◽  
Alba López‐Fernández ◽  
Raquel Rojas‐Márquez ◽  
Roberto Vélez ◽  
Màrius Aguirre ◽  
...  
Keyword(s):  
Umbilical Cord ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Wharton’S Jelly ◽  
Wharton's Jelly

Umbilical cord tissue derived mesenchymal stromal cells inhibit lysophosphatidylcholine mediated activation of microglia in organotypic cerebellar cultures

Cytotherapy ◽  
2017 ◽  
Vol 19 (5) ◽  
pp. S193
Author(s):  
A. Saha ◽  
L. Xu ◽  
R. Franczak ◽  
P. Noldner ◽  
N. Meadows ◽  
...  
Keyword(s):  
Umbilical Cord ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Umbilical Cord Tissue ◽  
Cerebellar Cultures

Umbilical cord blood mesenchymal stromal cells are neuroprotective and promote regeneration in a rat optic tract model

2009 ◽  
Vol 216 (2) ◽  
pp. 439-448 ◽  
Author(s):  
Isabel Zwart ◽  
Andrew J. Hill ◽  
Faisal Al-Allaf ◽  
Mili Shah ◽  
John Girdlestone ◽  
...  
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Mesenchymal Stromal Cells ◽  
Umbilical Cord Blood ◽  
Stromal Cells ◽  
Optic Tract
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